- Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease
[作者：Roxburgh, SA; Kattla, JJ; Curran, SP; O'Meara, YM; Pollock, CA; Goldschmeding, R; Godson, C; Martin, F; Brazil, DP,期刊：Diabetes, 页码：1641-1650 , 文章类型： Proceedings Paper，,卷期：2009年58-7]
- OBJECTIVE-Gremlin (grem1) is an antagonist of the bone morphogenetic protein family that plays a key role in limb bud development and kidney formation. There is a growing appreciation that altered grem1 expression may re...
- The Presence and Severity of Chronic Kidney Disease Predicts All-Cause Mortality in Type 1 Diabetes
[作者：Groop, PH; Thomas, MC; Moran, JL; Waden, J; Thorn, LM; Makinen, VP; Rosengard-Barlund, M; Saraheimo, M; Hietala, K; Heikkila, O; Forsblom, C,期刊：Diabetes, 页码：1651-1658 , 文章类型： Article，,卷期：2009年58-7]
- OBJECTIVES-This study aimed to identify clinical features associated with premature mortality in a large contemporary cohort of adults with type 1 diabetes. RESEARCH DESIGN AND METHODS-The Finnish Diabetic Nephropathy (F...
- Lack of Type VIII Collagen in Mice Ameliorates Diabetic Nephropathy
[作者：Hopfer, U; Hopfer, H; Meyer-Schwesinger, C; Loeffler, I; Fukai, N; Olsen, BR; Stahl, RAK; Wolf, G,期刊：Diabetes, 页码：1672-1681 , 文章类型： Proceedings Paper，,卷期：2009年58-7]
- OBJECTIVE-Key features of diabetic nephropathy include the accumulation of extracellular matrix proteins. In recent studies, increased expression of type VIII collagen in the glomeruli and tubulointerstitium of diabetic ...
- Common Variation in SIM1 Is Reproducibly Associated With BMI in Pima Indians
[作者：Traurig, M; Mack, J; Hanson, RL; Ghoussaini, M; Meyre, D; Knowler, WC; Kobes, S; Froguel, P; Bogardus, C; Baier, LJ,期刊：Diabetes, 页码：1682-1689 , 文章类型： Article，,卷期：2009年58-7]
- OBJECTIVE-Haploinsufficiency of SIM1 is a cause of rare monogenic obesity. To assess the role of SIM1 in polygenic obesity, this gene was analyzed in the Pima Indian population, which has a high prevalence of obesity. RE...
- Confirmation of Multiple Risk Loci and Genetic Impacts by a Genome-Wide Association Study of Type 2 Diabetes in the Japanese Population
[作者：Takeuchi, F; Serizawa, M; Yamamoto, K; Fujisawa, T; Nakashima, E; Ohnaka, K; Ikegami, H; Sugiyama, T; Katsuya, T; Miyagishi, M; Nakashima, N; Nawata, H; Nakamura, J; Kono, S; Takayanagi, R; Kato, N,期刊：Diabetes, 页码：1690-1699 , 文章类型： Article，,卷期：2009年58-7]
- OBJECTIVE-To identify novel type 2 diabetes gene variants and confirm previously identified ones, a three-staged genome-wide association study was performed in the Japanese population. RESEARCH DESIGN AND METHODS-In the ...
- NOD x 129.H2(g7) Backcross Delineates 129S1/SvImJ-Derived Genomic Regions Modulating Type 1 Diabetes Development in Mice
[作者：Leiter, EH; Reifsnyder, PC; Wallace, R; Li, RH; King, B; Churchill, GC,期刊：Diabetes, 页码：1700-1703 , 文章类型： Proceedings Paper，,卷期：2009年58-7]
- OBJECTIVE-Introduction of genes targeted in 129/Sv embryonic stem (ES) cells into NOD mice brings about linked genes that may modulate type 1 diabetes. Our objective was to identify 12951/SvJ non-MHC regions contributing...
- Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q
[作者：Prokopenko, I; Zeggini, E; Hanson, RL; Mitchell, BD; Rayner, NW; Akan, P; Baier, L; Das, SK; Elliott, KS; Fu, M; Frayling, TM; Groves, CJ; Gwilliam, R; Scott, LJ; Voight, BF; Hattersley, AT; Hu, C; Morris, AD; Ng, M; Palmer, CNA; Tello-Ruiz, M; Vaxillaire, M; Wang, CR; Stein, L; Chan, J; Jia, WP; Froguel, P; Elbein, SC; Deloukas, P; Bogardus, C; Shuldiner, AR; McCarthy, MI,期刊：Diabetes, 页码：1704-1709 , 文章类型： Article，,卷期：2009年58-7]
- OBJECTIVE-Linkage of the chromosome 1q21-25 region to type 2 diabetes has been demonstrated in multiple ethnic groups. We performed common variant fine-mapping across a 23-Mb interval in a multiethnic sample to search fo...
- Elevated MBL Concentrations Are Not an Indication of Association Between the MBL2 Gene and Type 1 Diabetes or Diabetic Nephropathy
[作者：Kaunisto, MA; Sjolind, L; Sallinen, R; Pettersson-Fernholm, K; Saraheimo, M; Frojdo, S; Forsblom, C; Fagerudd, J; Hansen, TK; Flyvbjerg, A; Wessman, M; Groop, PH,期刊：Diabetes, 页码：1710-1714 , 文章类型： Proceedings Paper，,卷期：2009年58-7]
- OBJECTIVE-Mannose-binding lectin (MBL) is an essential component of the acute-phase immune response and may thus play a role in the pathogenesis of type 1 diabetes and diabetic nephropathy. The serum concentration of MBL...
- Association of Type 2 Diabetes Candidate Polymorphisms in KCNQ1 With Incretin and Insulin Secretion
[作者：Mussig, K; Staiger, H; Machicao, F; Kirchhoff, K; Guthoff, M; Schafer, SA; Kantartzis, K; Silbernagel, G; Stefan, N; Holst, JJ; Gallwitz, B; Haring, HU; Fritsche, A,期刊：Diabetes, 页码：1715-1720 , 文章类型： Article，,卷期：2009年58-7]
- OBJECTIVE-KCNQ1 gene polymorphisms are associated with type 2 diabetes. This linkage appears to be mediated by altered beta-cell function. In an attempt to study underlying mechanisms, we examined the effect of four KCNQ...
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