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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共44条记录   Cortisol Release From Adipose Tissue by 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Humans [作者：Stimson, RH; Andersson, J; Andrew, R; Redhead, DN; Karpe, F; Hayes, PC; Olsson, T; Walker, BR,期刊：Diabetes, 页码：46-53 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-11 beta-Hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) regenerates cortisol from cortisone. 11 beta-HSD 1 mRNA and activity are increased in vitro in subcutaneous adipose tissue from obese patients. Inhibit... Retinol-Binding Protein 4 in Twins Regulatory Mechanisms and Impact of Circulating and Tissue Expression Levels on Insulin Secretion and Action [作者：Ribel-Madsen, R; Friedrichsen, M; Vaag, A; Poulsen, P,期刊：Diabetes, 页码：54-60 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-Retinol-binding protein (RBP) 4 is an adipokine of which plasma levels are elevated in obesity and type 2 diabetes. The aims of the study were to identify determinants of plasma RBP4 and RBP4 mRNA expression in... Adiponectin Upregulates Ferritin Heavy Chain in Skeletal Muscle Cells [作者：Ikegami, Y; Inukai, K; Mai, K; Sakamoto, Y; Katagiri, H; Kurihara, S; Awata, T; Katayama, S,期刊：Diabetes, 页码：61-70 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-Adiponectin is an adipocyte-derived protein that acts to reduce insulin resistance in the liver and muscle and also inhibits atherosclerosis. Although adiponectin reportedly enhances AMP-activated protein kinas... Mid- and Late-Life Diabetes in Relation to the Risk of Dementia A Population-Based Twin Study [作者：Xu, WL; Qiu, CX; Gatz, M; Pedersen, NL; Johansson, B; Fratiglioni, L,期刊：Diabetes, 页码：71-77 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-We aimed to verify the association between diabetes and the risk of dementia, Alzheimer's disease, and vascular dementia in twins and to explore whether genetic and early-life environmental factors could contri... Restoration of Hepatic Glucokinase Expression Corrects Hepatic Glucose Flux and Normalizes Plasma Glucose in Zucker Diabetic Fatty Rats [作者：Torres, TP; Catlin, RL; Chan, R; Fujimoto, Y; Sasaki, N; Printz, RL; Newgard, CB; Shiota, M,期刊：Diabetes, 页码：78-86 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-We examined in 20-week-old Zucker diabetic fatty (ZDF) rats whether restoration of hepatic glucokinase (GK) expression would alter hepatic glucose flux and improve hyper-glycemia.RESEARCH DESIGN AND METHODS-ZDF... Xenin, a Gastrointestinal Peptide, Regulates Feeding Independent of the Melanocortin Signaling Pathway [作者：Leckstrom, A; Kim, ER; Wong, D; Mizuno, TM,期刊：Diabetes, 页码：87-94 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-Xenin, a 25-amino acid peptide, was initially isolated from human gastric mucosa. Plasma levels of xenin rise after a meal in humans, and administration of xenin inhibits feeding in rats and chicks. However, li... Hypoxia Decreases Insulin Signaling Pathways in Adipocytes [作者：Regazzetti, C; Peraldi, P; Gremeaux, T; Najem-Lendom, R; Ben-Sahra, I; Cormont, M; Bost, F; Le Marchand-Brustel, Y; Tanti, JF; Giorgetti-Peraldi, S,期刊：Diabetes, 页码：95-103 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-Obesity is characterized by an overgrowth of adipose tissue that leads to the formation of hypoxic areas within this tissue. We investigated whether this phenomenon could be responsible for insulin resistance b... Can We Learn From Viruses How to Prevent Type 1 Diabetes? The Role of Viral Infections in the Pathogenesis of Type 1 Diabetes and the Development of Novel Combination Therapies [作者：von Herrath, M,期刊：Diabetes, 页码：2-11 , 文章类型： Article，,卷期：2009年58-1] We will take a journey from basic pathogenetic mechanisms elicited by viral infections that play a role in the development of type 1 diabetes to clinical interventions, where we will discuss novel combination therapies. ... Increased Secretion and Expression of Myostatin in Skeletal Muscle From Extremely Obese Women [作者：Hittel, DS; Berggren, JR; Shearer, J; Boyle, K; Houmard, JA,期刊：Diabetes, 页码：30-38 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-Obesity is associated with endocrine abnormalities that predict the progression of insulin resistance to type 2 diabetes. Because skeletal muscle has been shown to secrete proteins that could be used as biomark... Liver Is the Site of Splanchnic Cortisol Production in Obese Nondiabetic Humans [作者：Basu, R; Basu, A; Grudzien, M; Jung, P; Jacobson, P; Johnson, M; Singh, R; Sarr, M; Rizza, RA,期刊：Diabetes, 页码：39-45 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-To determine the contribution of liver and viscera to splanchnic cortisol production in humans.RESEARCH DESIGN AND METHODS-D4 cortisol was infused intravenously; arterial, portal venous, and hepatic venous bloo... All-trans Retinoic Acid Inhibits Type 1 Diabetes by T Regulatory (Treg)-Dependent Suppression of Interferon-gamma-Producing T-cells Without Affecting Th17 Cells [作者：Van, YH; Lee, WH; Ortiz, S; Lee, MH; Qin, HJ; Liu, CP,期刊：Diabetes, 页码：146-155 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-All-trans retinoic acid (ATRA), a potent derivative of vitamin A, can regulate immune responses. However, its role in inducing immune tolerance associated with the prevention of islet inflammation and inhibitio... Slc11a1 Enhances the Autoimmune Diabetogenic T-Cell Response by Altering Processing and Presentation of Pancreatic Islet Antigens [作者：Dai, YD; Marrero, IG; Gros, P; Zaghouani, H; Wicker, LS; Sercarz, EE,期刊：Diabetes, 页码：156-164 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-Efforts to map non-major histocompatibility complex (MHC) genes causing type 1 diabetes in NOD mice identified Slc11a1, formerly Nramp1, as the leading candidate gene in the Idd5.2 region. Slc11a1 is a membrane... Idd Loci Synergize to Prolong Islet Allograft Survival Induced by Costimulation Blockade in NOD Mice [作者：Mangada, J; Pearson, T; Brehm, MA; Wicker, LS; Peterson, LB; Shultz, LD; Serreze, DV; Rossini, AA; Greiner, DL,期刊：Diabetes, 页码：165-173 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-NOD mice model human type 1 diabetes and are used to investigate tolerance induction protocols for islet transplantation in a setting of autoimmunity. However, costimulation blockade-based tolerance protocols h... Inhibition of Dipeptidyl Peptidase-4 by Vildagliptin During Glucagon-Like Peptide 1 Infusion Increases Liver Glucose Uptake in the Conscious Dog [作者：Edgerton, DS; Johnson, KMS; Neal, DW; Scott, M; Hobbs, CH; Zhang, X; Duttaroy, A; Cherrington, AD,期刊：Diabetes, 页码：243-249 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-This study investigated the acute effects of treatment with vildagliptin on dipeptidyl peptidase-4 (DPP-4) activity, glucagon-like peptide 1 (GLP-1) concentration, pancreatic hormone levels, and glucose metabol... Fibroblast Growth Factor 21 Reverses Hepatic Steatosis, Increases Energy Expenditure, and Improves Insulin Sensitivity in Diet-Induced Obese Mice [作者：Xu, J; Lloyd, DJ; Hale, C; Stanislaus, S; Chen, M; Sivits, G; Vonderfecht, S; Hecht, R; Li, YS; Lindberg, RA; Chen, JL; Jung, DY; Zhang, ZY; Ko, HJ; Kim, JK; Veniant, MM,期刊：Diabetes, 页码：250-259 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-Fibroblast growth factor 21 (FGF21) has emerged as an important metabolic regulator of glucose and lipid metabolism. The aims of the current study are to evaluate the role of FGF21 in energy metabolism and to p... Regulation of Calcium-Permeable TRPV2 Channel by Insulin in Pancreatic beta-Cells [作者：Hisanaga, E; Nagasawa, M; Ueki, K; Kulkarni, RN; Mori, M; Kojima, I,期刊：Diabetes, 页码：174-184 , 文章类型： Article，,卷期：2009年58-1] OBJECTIVE-Calcium-permeable cation channel TRPV2 is expressed in pancreatic beta-cells. We investigated regulation and function of TRPV2 in beta-cells.RESEARCH DESIGN AND METHODS-Translocation of TRPV2 was assessed in MI...