- A Role for the Low-Affinity A(2B) Adenosine Receptor in Regulating Superoxide Generation by Murine Neutrophils
[作者:van der Hoeven, D; Wan, TC; Gizewski, ET; Kreckler, LM; Maas, JE; Van Orman, J; Ravid, K; Auchampach, JA,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1004-1012 , 文章类型: Article,,卷期:2011年338-3]
- The formation of adenosine dampens inflammation by inhibiting most cells of the immune system. Among its actions on neutrophils, adenosine suppresses superoxide generation and regulates chemotactic activity. To date, mos...
- Luteolin, a Novel Natural Inhibitor of Tumor Progression Locus 2 Serine/Threonine Kinase, Inhibits Tumor Necrosis Factor-alpha-Induced Cyclooxygenase-2 Expression in JB6 Mouse Epidermis Cells
[作者:Kim, JE; Son, JE; Jang, YJ; Lee, DE; Kang, NJ; Jung, SK; Heo, YS; Lee, KW; Lee, HJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1013-1022 , 文章类型: Article,,卷期:2011年338-3]
- Targeting tumor necrosis factor (TNF)-alpha-mediated signal pathways may be a promising strategy for developing chemopreventive agents, because TNF-alpha-mediated cyclooxygenase (COX)-2 expression plays a key role in inf...
- Donepezil Improves Cognitive Function in Mice by Increasing the Production of Insulin-Like Growth Factor-I in the Hippocampus (vol 330, pg 2, 2009)
[作者:Narimatsu, N; Harada, N; Kurihara, H; Nakagata, N; Sobue, K; Okajima, K,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:1023-1023 , 文章类型: Correction,,卷期:2011年338-3]
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- Synergistic Effects of p38 Mitogen-Activated Protein Kinase Inhibition with a Corticosteroid in Alveolar Macrophages from Patients with Chronic Obstructive Pulmonary Disease
[作者:Armstrong, J; Harbron, C; Lea, S; Booth, G; Cadden, P; Wreggett, KA; Singh, D,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:732-740 , 文章类型: Article,,卷期:2011年338-3]
- Corticosteroids partially suppress cytokine production by chronic obstructive pulmonary disease (COPD) alveolar macrophages, p38 mitogen-activated protein kinase (MAPK) inhibitors are a novel class of anti-inflammatory d...
- Role of Calcium-Activated Potassium Channels in the Genesis of 3,4-Diaminopyridine-Induced Periodic Contractions in Isolated Canine Coronary Artery Smooth Muscles
[作者:Uchida, Y; Maezawa, Y; Maezawa, Y; Uchida, Y; Nakamura, F,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:974-983 , 文章类型: Article,,卷期:2011年338-3]
- We found that 3,4-diaminopyridine (3,4-DAP), a voltage-gated potassium channel (K(V)) inhibitor, elicits pH-sensitive periodic contractions (PCs) of coronary smooth muscles. Underlying mechanisms of PCs, however, remaine...
- In Vivo Pharmacology and Toxicology Evaluation of Polyethylene Glycol-Conjugated Interferon beta-1a
[作者:Hu, X; Olivier, K; Polack, E; Crossman, M; Zokowski, K; Gronke, RS; Parker, S; Li, ZY; Nestorov, I; Baker, DP; Clarke, J; Subramanyam, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:984-996 , 文章类型: Article,,卷期:2011年338-3]
- Human interferon (IFN) beta has well established beneficial effects in treating relapsing forms of multiple sclerosis, but current first-line treatment requires frequent (from daily to weekly) parenteral administration. ...
- The Repressor Element 1-Silencing Transcription Factor Is a Novel Molecular Target for the Neurotoxic Effect of the Polychlorinated Biphenyl Mixture Aroclor 1254 in Neuroblastoma SH-SY5Y Cells
[作者:Formisano, L; Guida, N; Cocco, S; Secondo, A; Sirabella, R; Ulianich, L; Paturzo, F; Di Renzo, G; Canzoniero, LMT,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:997-1003 , 文章类型: Article,,卷期:2011年338-3]
- Chronic exposure to polychlorinated biphenyls (PCBs), a class of ubiquitous environmental toxicants, causes neurocognitive anomalies. The transcription factor repressor element 1-silencing transcription factor (REST) pla...
- Administration of Naked Plasmid Encoding Hepatic Stimulator Substance by Hydrodynamic Tail Vein Injection Protects Mice from Hepatic Failure by Suppressing the Mitochondrial Permeability Transition
[作者:Li, SL; Tang, ZQ; Yu, H; Li, W; Jiang, Y; Wang, YT; An, W,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:750-757 , 文章类型: Article,,卷期:2011年338-3]
- Acute liver failure is a devastating illness of various causes with considerable mortality. Hepatic stimulator substance (HSS) has been suggested for use as a protective agent against acute hepatic injury induced by chem...
- Delayed Administration of Suramin Attenuates the Progression of Renal Fibrosis in Obstructive Nephropathy
[作者:Liu, N; Tolbert, E; Ponnusamy, M; Yan, HD; Zhuang, SG,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:758-766 , 文章类型: Article,,卷期:2011年338-3]
- We recently showed that suramin treatment prevents the onset of renal fibrosis in a model of obstructive nephropathy induced by unilateral ureteral obstruction (UUO). In this study, we further assessed the effect of dela...
- Mechanisms Underlying the Renoprotective Effect of GABA against Ischemia/Reperfusion-Induced Renal Injury in Rats
[作者:Kobuchi, S; Tanaka, R; Shintani, T; Suzuki, R; Tsutsui, H; Ohkita, M; Ayajiki, K; Matsumura, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:767-774 , 文章类型: Article,,卷期:2011年338-3]
- The excitation of the renal sympathetic nervous system plays an important role in the development of ischemic acute kidney injury (AKI) in rats. We have reported that intravenous treatment with GABA has preventive effect...
- Oxidative Stress Mediates through Apoptosis the Anticancer Effect of Phospho-Nonsteroidal Anti-Inflammatory Drugs: Implications for the Role of Oxidative Stress in the Action of Anticancer Agents
[作者:Sun, Y; Huang, LQ; Mackenzie, GG; Rigas, B,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:775-783 , 文章类型: Article,,卷期:2011年338-3]
- We assessed the relationship between oxidative stress, cytokinetic parameters, and tumor growth in response to novel phospho-nonsteroidal anti-inflammatory drugs (NSAIDs), agents with significant anticancer effects in pr...
- Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy
[作者:Hori, YS; Kuno, A; Hosoda, R; Tanno, M; Miura, T; Shimamoto, K; Horio, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:784-794 , 文章类型: Article,,卷期:2011年338-3]
- Muscular dystrophies are inherited myogenic disorders accompanied by progressive skeletal muscle weakness and degeneration. We previously showed that resveratrol (3,5,4'-trihydroxy-trans-stilbene), an antioxidant and act...
- Inhibition of Monoacylglycerol Lipase Attenuates Nonsteroidal Anti-Inflammatory Drug-Induced Gastric Hemorrhages in Mice
[作者:Kinsey, SG; Nomura, DK; O'Neal, ST; Long, JZ; Mahadevan, A; Cravatt, BF; Grider, JR; Lichtman, AH,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:795-802 , 文章类型: Article,,卷期:2011年338-3]
- Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used analgesics, but can cause gastric and esophageal hemorrhages, erosion, and ulceration. The endogenous cannabinoid (endocannabinoid; eCB) system possesses se...
- Polymorphic Variants of Cytochrome P450 2B6 (CYP2B6.4-CYP2B6.9) Exhibit Altered Rates of Metabolism for Bupropion and Efavirenz: A Charge-Reversal Mutation in the K139E Variant (CYP2B6.8) Impairs Formation of a Functional Cytochrome P450-Reductase Complex
[作者:Zhang, HM; Sridar, C; Kenaan, C; Amunugama, H; Ballou, DP; Hollenberg, PF,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:803-809 , 文章类型: Article,,卷期:2011年338-3]
- In this study, metabolism of bupropion, efavirenz, and 7-ethoxy-4-trifluoromethylcoumarin (7-EFC) by CYP2B6 wild type (CYP2B6.1) and six polymorphic variants (CYP2B6.4 to CYP2B6.9) was investigated in a reconstituted sys...
- Therapeutic Effect of Lecithinized Superoxide Dismutase on Pulmonary Emphysema
[作者:Tanaka, KI; Tanaka, Y; Miyazaki, Y; Namba, T; Sato, K; Aoshiba, K; Azuma, A; Mizushima, T,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:810-818 , 文章类型: Article,,卷期:2011年338-3]
- No medication exists that clearly improves the mortality of chronic obstructive pulmonary disease (COPD). Oxidative molecules, in particular superoxide anions, play important roles in the COPD-associated abnormal inflamm...
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