- Ginseng (Panax quinquefolius) Attenuates Leptin-Induced Cardiac Hypertrophy through Inhibition of p115Rho Guanine Nucleotide Exchange Factor-RhoA/Rho-Associated, Coiled-Coil Containing Protein Kinase-Dependent Mitogen-Activated Protein Kinase Pathway Activation
[作者:Moey, M; Rajapurohitam, V; Zeidan, A; Karmazyn, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:746-756 , 文章类型: Article,,卷期:2011年339-3]
- Leptin is a 16-kDa peptide primarily derived from white adipocytes and is typically elevated in plasma of obese individuals. Although leptin plays a critical role in appetite regulation, leptin receptors have been identi...
- Indirect Sympatholytic Actions at beta-Adrenoceptors Account for the Ocular Hypotensive Actions of Cannabinoid Receptor Agonists
[作者:Hudson, BD; Beazley, M; Szczesniak, AM; Straiker, A; Kelly, MEM,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:757-767 , 文章类型: Article,,卷期:2011年339-3]
- Intraocular pressure (IOP) is the primary risk factor for glaucoma, a blinding eye disease. Cannabinoid agonists have long been known to decrease IOP, suggesting they may be useful in glaucoma treatment. However, the spe...
- Impact of Pyrrolidine Dithiocarbamate and Interleukin-6 on Mammalian Target of Rapamycin Complex 1 Regulation and Global Protein Translation
[作者:Song, SM; Abdelmohsen, K; Zhang, YQ; Becker, KG; Gorospe, M; Bernier, M,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:905-913 , 文章类型: Article,,卷期:2011年339-3]
- Interleukin-6 (IL-6) is a proinflammatory cytokine that exerts a wide range of cellular, physiological, and pathophysiological responses. Pyrrolidine dithiocarbamate (PDTC) antagonizes the cellular responsiveness to IL-6...
- Quantitative Pharmacokinetic/Pharmacodynamic Analyses Suggest That the 129/SVE Mouse Is a Suitable Preclinical Pharmacology Model for Identifying Small-Molecule gamma-Secretase Inhibitors
[作者:Lu, YS; Zhang, LM; Nolan, CE; Becker, SL; Atchison, K; Robshaw, AE; Pustilnik, LR; Osgood, SM; Miller, EH; Stepan, AF; Subramanyam, C; Efremov, I; Hallgren, AJ; Riddell, D,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:922-934 , 文章类型: Article,,卷期:2011年339-3]
- Alzheimer's disease (AD) poses a serious public health threat to the United States. Disease-modifying drugs slowing AD progression are in urgent need, but they are still unavailable. According to the amyloid cascade hypo...
- Effect of Dimerized Thrombin Fragment TP508 on Acute Myocardial Ischemia Reperfusion Injury in Hypercholesterolemic Swine (vol 334, pg 449, 2010)
[作者:Oyamada, S; Osipov, R; Bianchi, C; Robich, MP; Feng, J; Liu, Y; Burgess, TA; Bell, TM; Sheller, MR; Sellke, FW,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:959-959 , 文章类型: Correction,,卷期:2011年339-3]
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- Quantitative Evaluation of the Impact of Active Efflux by P-Glycoprotein and Breast Cancer Resistance Protein at the Blood-Brain Barrier on the Predictability of the Unbound Concentrations of Drugs in the Brain Using Cerebrospinal Fluid Concentration as a Surrogate
[作者:Kodaira, H; Kusuhara, H; Fujita, T; Ushiki, J; Fuse, E; Sugiyama, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:935-944 , 文章类型: Article,,卷期:2011年339-3]
- This study investigated the impact of the active efflux mediated by P-glycoprotein (P-gp) and breast cancer resistance protein (Bcrp) at the blood-brain barrier (BBB) on the predictability of the unbound brain concentrat...
- Preventive Effect of GGsTop, a Novel and Selective gamma-Glutamyl Transpeptidase Inhibitor, on Ischemia/Reperfusion-Induced Renal Injury in Rats
[作者:Yamamoto, S; Watanabe, B; Hiratake, J; Tanaka, R; Ohkita, M; Matsumura, Y,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:945-951 , 文章类型: Article,,卷期:2011年339-3]
- GGsTop [2-amino-4-{[3-(carboxymethyl)phenyl](methyl)phosphono}butanoic acid], is a novel, highly selective, and irreversible gamma-glutamyl transpeptidase (GGT) inhibitor with no inhibitory activity on glutamine amidotra...
- Effects of Ranolazine on Cloned Cardiac Kv4.3 Potassium Channels
[作者:Kim, HJ; Ahn, HS; Choi, JS; Choi, BH; Hahn, SJ,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:952-958 , 文章类型: Article,,卷期:2011年339-3]
- The effects of ranolazine, an antianginal drug, on potassium channel Kv4.3 were examined by using the whole-cell patch-clamp technique. Ranolazine inhibited the peak amplitude of Kv4.3 in a reversible, concentration-depe...
- A Selective Cysteinyl Leukotriene Receptor 2 Antagonist Blocks Myocardial Ischemia/Reperfusion Injury and Vascular Permeability in Mice
[作者:Ni, NC; Yan, D; Ballantyne, LL; Barajas-Espinosa, A; St Amand, T; Pratt, DA; Funk, CD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:768-778 , 文章类型: Article,,卷期:2011年339-3]
- Cysteinyl leukotrienes (CysLTs) are potent inflammatory mediators that predominantly exert their effects by binding to cysteinyl leukotriene receptors of the G protein-coupled receptor family. CysLT receptor 2 (CysLT(2)R...
- Therapeutic Potential of Pegylated Hemin for Reactive Oxygen Species-Related Diseases via Induction of Heme Oxygenase-1: Results from a Rat Hepatic Ischemia/Reperfusion Injury Model
[作者:Fang, J; Qin, HB; Seki, T; Nakamura, H; Tsukigawa, K; Shin, T; Maeda, H,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:779-789 , 文章类型: Article,,卷期:2011年339-3]
- Many diseases and pathological conditions, including ischemia/reperfusion (I/R) injury, are the consequence of the actions of reactive oxygen species (ROS). Controlling ROS generation or its level may thus hold promise a...
- Serotonin Receptor Type 3 Antagonists Improve Obesity-Associated Fatty Liver Disease in Mice
[作者:Haub, S; Ritze, Y; Ladel, I; Saum, K; Hubert, A; Spruss, A; Trautwein, C; Bischoff, SC,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:790-798 , 文章类型: Article,,卷期:2011年339-3]
- Obesity is a major cause for nonalcoholic fatty liver disease (NAFLD). Previous studies suggested that alterations in intestinal motility and permeability contribute to the development of NAFLD. Serotonin and serotonin r...
- The Microtubule Depolymerizing Agent CYT997 Causes Extensive Ablation of Tumor Vasculature In Vivo
[作者:Burns, CJ; Fantino, E; Powell, AK; Shnyder, SD; Cooper, PA; Nelson, S; Christophi, C; Malcontenti-Wilson, C; Dubljevic, V; Harte, MF; Joffe, M; Phillips, ID; Segal, D; Wilks, AF; Smith, GD,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:799-806 , 文章类型: Article,,卷期:2011年339-3]
- The orally active microtubule-disrupting agent (S)-1-ethyl-3-(2-methoxy-4-(5-methyl-4-((1-(pyridin-3-yl)butyl)amino)pyrimidin-2-yl)phenyl)urea (CYT997), reported previously by us (Bioorg Med Chem Lett 19:4639-4642, 2009;...
- Oxidative Stress and Myocardial Gene Alterations Associated with Doxorubicin-Induced Cardiotoxicity in Rats Persist for 2 Months after Treatment Cessation
[作者:Richard, C; Ghibu, S; Delemasure-Chalumeau, S; Guilland, JC; Des Rosiers, C; Zeller, M; Cottin, Y; Rochette, L; Vergely, C,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:807-814 , 文章类型: Article,,卷期:2011年339-3]
- The molecular mechanisms underlying doxorubicin (DOX)-induced cardiomyopathy include alterations in cardiomyocytes' oxidative stress status and in gene expression. Although such alterations have been reported during in v...
- Estrogen Increases Nitric-Oxide Production in Human Bronchial Epithelium
[作者:Townsend, EA; Meuchel, LW; Thompson, MA; Pabelick, CM; Prakash, YS,期刊:Journal of Pharmacology and Experimental Therapeutics, 页码:815-824 , 文章类型: Article,,卷期:2011年339-3]
- Although sex differences in asthma severity are recognized, the mechanisms by which sex steroids such as estrogen influence the airway are still under investigation. Airway tone, a key aspect of asthma, represents a bala...
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