- Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation
[作者:Hindley, C; Ali, F; McDowell, G; Cheng, K; Jones, A; Guillemot, F; Philpott, A,期刊:Development, 页码:1718-1723 , 文章类型: Article,,卷期:2012年139-10]
- Neurogenin 2 (Ngn2) controls neuronal differentiation cell-autonomously by transcriptional activation of targets such as NeuroD, while simultaneously controlling progenitor maintenance non-cell-autonomously by upregulati...
- WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum
[作者:Pei, YX; Brun, SN; Markant, SL; Lento, W; Gibson, P; Taketo, MM; Giovannini, M; Gilbertson, RJ; Wechsler-Reya, RJ,期刊:Development, 页码:1724-1733 , 文章类型: Article,,卷期:2012年139-10]
- The WNT pathway plays multiple roles in neural development and is crucial for establishment of the embryonic cerebellum. In addition, WNT pathway mutations are associated with medulloblastoma, the most common malignant b...
- Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells
[作者:Afelik, S; Qu, XL; Hasrouni, E; Bukys, MA; Deering, T; Nieuwoudt, S; Rogers, W; MacDonald, RJ; Jensen, J,期刊:Development, 页码:1744-1753 , 文章类型: Article,,卷期:2012年139-10]
- Early pancreatic morphogenesis is characterized by the transformation of an uncommitted pool of pancreatic progenitor cells into a branched pancreatic epithelium that consists of 'tip' and 'trunk' domains. These domains ...
- p120-catenin is essential for terminal end bud function and mammary morphogenesis
[作者:Kurley, SJ; Bierie, B; Carnahan, RH; Lobdell, NA; Davis, MA; Hofmann, I; Moses, HL; Muller, WJ; Reynolds, AB,期刊:Development, 页码:1754-1764 , 文章类型: Article,,卷期:2012年139-10]
- Although p120-catenin (p120) is crucial for E-cadherin function, ablation experiments in epithelial tissues from different organ systems reveal markedly different effects. Here, we examine for the first time the conseque...
- The role of hair cells, cilia and ciliary motility in otolith formation in the zebrafish otic vesicle
[作者:Stooke-Vaughan, GA; Huang, P; Hammond, KL; Schier, AF; Whitfield, TT,期刊:Development, 页码:1777-1787 , 文章类型: Article,,卷期:2012年139-10]
- Otoliths are biomineralised structures required for the sensation of gravity, linear acceleration and sound in the zebrafish ear. Otolith precursor particles, initially distributed throughout the otic vesicle lumen, beco...
- A GATA/homeodomain transcriptional code regulates axon guidance through the Unc-5 receptor
[作者:Zarin, AA; Daly, AC; Holsmeier, J; Asadzadeh, J; Labrador, JP,期刊:Development, 页码:1798-1805 , 文章类型: Article,,卷期:2012年139-10]
- Transcription factor codes play an essential role in neuronal specification and axonal guidance in both vertebrate and invertebrate organisms. However, how transcription codes regulate axon pathfinding remains poorly und...
- Bcl11a is required for neuronal morphogenesis and sensory circuit formation in dorsal spinal cord development
[作者:John, A; Brylka, H; Wiegreffe, C; Simon, R; Liu, PT; Juttner, R; Crenshaw, EB; Luyten, FP; Jenkins, NA; Copeland, NG; Birchmeier, C; Britsch, S,期刊:Development, 页码:1831-1841 , 文章类型: Article,,卷期:2012年139-10]
- Dorsal spinal cord neurons receive and integrate somatosensory information provided by neurons located in dorsal root ganglia. Here we demonstrate that dorsal spinal neurons require the Kruppel-(CH2)-H-2 zinc-finger tran...
- The novel intestinal filament organizer IFO-1 contributes to epithelial integrity in concert with ERM-1 and DLG-1
[作者:Carberry, K; Wiesenfahrt, T; Geisler, F; Stocker, S; Gerhardus, H; Uberbach, D; Davis, W; Jorgensen, E; Leube, RE; Bossinger, O,期刊:Development, 页码:1851-1862 , 文章类型: Article,,卷期:2012年139-10]
- The nematode Caenorhabditis elegans is an excellent model system in which to study in vivo organization and function of the intermediate filament (IF) system for epithelial development and function. Using a transgenic if...
- Identification of molecular compartments and genetic circuitry in the developing mammalian kidney
[作者:Yu, J; Valerius, MT; Duah, M; Staser, K; Hansard, JK; Guo, JJ; McMahon, J; Vaughan, J; Faria, D; Georgas, K; Rumballe, B; Ren, Q; Krautzberger, AM; Junker, JP; Thiagarajan, RD; Machanick, P; Gray, PA; van Oudenaarden, A; Rowitch, DH; Stiles, CD; Ma, QF; Grimmond, SM; Bailey, TL; Little, MH; McMahon, AP,期刊:Development, 页码:1863-1873 , 文章类型: Article,,卷期:2012年139-10]
- Lengthy developmental programs generate cell diversity within an organotypic framework, enabling the later physiological actions of each organ system. Cell identity, cell diversity and cell function are determined by cel...
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