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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共34条记录   New Treatments for Rhabdomyosarcoma: The Importance of Target Practice [作者：Barr, FG,期刊：Clinical Cancer Research, 页码：595-597 , 文章类型： Editorial Material，,卷期：2012年18-3] To address the poor outcomes in rhabdomyosarcoma, particularly the alveolar subtype, new therapies are needed. Potential cancer-specific alterations that may be molecular targets include gene fusions or copy number chang... Molecular Pathways: Targeting Mechanisms of Asbestos and Erionite Carcinogenesis in Mesothelioma [作者：Carbone, M; Yang, HN,期刊：Clinical Cancer Research, 页码：598-604 , 文章类型： Article，,卷期：2012年18-3] Malignant mesothelioma is an aggressive malignancy related to asbestos and erionite exposure. AP-1 transcriptional activity and the NF-kappa B signaling pathway have been linked to mesothelial cell transformation and tum... A Millennium Goal for Cancer [作者：Bates, SE,期刊：Clinical Cancer Research, 页码：606-606 , 文章类型： Editorial Material，,卷期：2012年18-3] Overview of the AACR Clinical and Translational Cancer Research Think Tank Meeting [作者：Anderson, KC; DuBois, RN,期刊：Clinical Cancer Research, 页码：607-611 , 文章类型： Editorial Material，,卷期：2012年18-3] Impact of Genomics on Personalized Cancer Medicine [作者：Arteaga, CL; Baselga, J,期刊：Clinical Cancer Research, 页码：612-618 , 文章类型： Article，,卷期：2012年18-3] Recent advances in tumor genetics and drug development have led to the generation of a wealth of anticancer targeted therapies. A few recent examples indicate that these drugs are mainly, if not exclusively, active again... Making Personalized Cancer Medicine a Reality: Challenges and Opportunities in the Development of Biomarkers and Companion Diagnostics [作者：Parkinson, DR; Johnson, BE; Sledge, GW,期刊：Clinical Cancer Research, 页码：619-624 , 文章类型： Article，,卷期：2012年18-3] The origins of this article stem from discussions at the American Association for Cancer Research Clinical and Translational Cancer Research Think Tank meeting held in San Francisco in early 2010. This article synthesize... Genetically Modified Mouse Models for Biomarker Discovery and Preclinical Drug Testing [作者：Kucherlapati, R,期刊：Clinical Cancer Research, 页码：625-630 , 文章类型： Article，,卷期：2012年18-3] The ability to grow pluripotent mouse embryonic stem cells in culture, and to introduce precise genetic modifications into those cells through gene targeting, has greatly facilitated the generation of mouse models of hum... Imaging: Strategies, Controversies, and Opportunities [作者：Blasberg, R; Piwnica-Worms, D,期刊：Clinical Cancer Research, 页码：631-637 , 文章类型： Article，,卷期：2012年18-3] At a Clinical and Translational Cancer Research Think Tank meeting sponsored by the American Association for Cancer Research in 2010, one of the breakout groups focused on new technologies and imaging. The discussions em... Reports from the 2010 Clinical and Translational Cancer Research Think Tank Meeting: Design Strategies for Personalized Therapy Trials [作者：Berry, DA; Herbst, RS; Rubin, EH,期刊：Clinical Cancer Research, 页码：638-644 , 文章类型： Article，,卷期：2012年18-3] It has long been evident that cancer is a heterogeneous disease, but only relatively recently have we come to realize the extent of this heterogeneity. No single therapy is effective for every patient with tumors having ... Cancer Dormancy: A Model of Early Dissemination and Late Cancer Recurrence [作者：Paez, D; Labonte, MJ; Bohanes, P; Zhang, W; Benhanim, L; Ning, Y; Wakatsuki, T; Loupakis, F; Lenz, HJ,期刊：Clinical Cancer Research, 页码：645-653 , 文章类型： Review，,卷期：2012年18-3] Cancer dormancy is a stage in tumor progression in which residual disease remains occult and asymptomatic for a prolonged period of time. Dormant tumor cells can be present as one of the earliest stages in tumor developm... Notch Signaling Promotes Growth and Invasion in Uveal Melanoma [作者：Asnaghi, L; Ebrahimi, KB; Schreck, KC; Bar, EE; Coonfield, ML; Bell, WR; Handa, J; Merbs, SL; Harbour, JW; Eberhart, CG,期刊：Clinical Cancer Research, 页码：654-665 , 文章类型： Article，,卷期：2012年18-3] Purpose: To determine whether uveal melanoma, the most common primary intraocular malignancy in adults, requires Notch activity for growth and metastasis. Experimental Design: Expression of Notch pathway members was char... Modeling a Lethal Prostate Cancer Variant with Small-Cell Carcinoma Features [作者：Tzelepi, V; Zhang, JX; Lu, JF; Kleb, B; Wu, GL; Wan, XH; Hoang, A; Efstathiou, E; Sircar, K; Navone, NM; Troncoso, P; Liang, SD; Logothetis, CJ; Maity, SN; Aparicio, AM,期刊：Clinical Cancer Research, 页码：666-677 , 文章类型： Article，,卷期：2012年18-3] Purpose: Small-cell prostate carcinoma (SCPC) morphology predicts for a distinct clinical behavior, resistance to androgen ablation, and frequent but short responses to chemotherapy. We sought to develop model systems th... Expansion of a CD8(+)PD-1(+) Replicative Senescence Phenotype in Early Stage CLL Patients Is Associated with Inverted CD4:CD8 Ratios and Disease Progression [作者：Nunes, C; Wong, R; Mason, M; Fegan, C; Man, S; Pepper, C,期刊：Clinical Cancer Research, 页码：678-687 , 文章类型： Article，,卷期：2012年18-3] Purpose: Patients with chronic lymphocytic leukemia (CLL) display immune deficiency that is most obvious in advanced stage disease. Here we investigated whether this immune dysfunction plays a pathologic role in the prog... Primary Colorectal Cancers and Their Subsequent Hepatic Metastases Are Genetically Different: Implications for Selection of Patients for Targeted Treatment [作者：Vermaat, JS; Nijman, IJ; Koudijs, MJ; Gerritse, FL; Scherer, SJ; Mokry, M; Roessingh, WM; Lansu, N; de Bruijn, E; van Hillegersberg, R; van Diest, PJ; Cuppen, E; Voest, EE,期刊：Clinical Cancer Research, 页码：688-699 , 文章类型： Article，,卷期：2012年18-3] Purpose: In the era of DNA-guided personalized cancer treatment, it is essential to conduct predictive analysis on the tissue that matters. Here, we analyzed genetic differences between primary colorectal adenocarcinomas... Genome-Wide CpG Island Profiling of Intraductal Papillary Mucinous Neoplasms of the Pancreas [作者：Hong, SM; Omura, N; Vincent, A; Li, A; Knight, S; Yu, J; Hruban, RH; Goggins, M,期刊：Clinical Cancer Research, 页码：700-712 , 文章类型： Article，,卷期：2012年18-3] Purpose: Intraductal papillary mucinous neoplasms (IPMN) are precursors to infiltrating pancreatic ductal adenocarcinomas. Widespread epigenetic alterations are characteristic of many cancers, yet few studies have system... Upregulated IL-19 in Breast Cancer Promotes Tumor Progression and Affects Clinical Outcome [作者：Hsing, CH; Cheng, HC; Hsu, YH; Chan, CH; Yeh, CH; Li, CF; Chang, MS,期刊：Clinical Cancer Research, 页码：713-725 , 文章类型： Article，,卷期：2012年18-3] Purpose: Interleukin (IL)-19 was expressed in invasive ductal carcinoma (IDC) of the breast tissue but not in healthy breast tissue. We explored the effects of IL-19 on the pathogenesis of breast cancer and its clinical ...