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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共31条记录   Rehabilitation for Oncogene Addiction: Role of Immunity in Cellular Sobriety [作者：Bajor, DL; Vonderheide, RH,期刊：Clinical Cancer Research, 页码：1192-1194 , 文章类型： Editorial Material，,卷期：2012年18-5] Clinical responses to oncogene inhibitors result from direct effects on cell-intrinsic growth signals and disruption of downstream messages that produce a protumor immunosuppressive microenvironment. Combining oncogene-t... New Strategies in Melanoma: Molecular Testing in Advanced Disease [作者：Woodman, SE; Lazar, AJ; Aldape, KD; Davies, MA,期刊：Clinical Cancer Research, 页码：1195-1200 , 文章类型： Article，,卷期：2012年18-5] Melanoma is one of the most aggressive forms of skin cancer. The management of melanoma is evolving rapidly due to an improved understanding of the molecular heterogeneity of this disease and the development of effective... Molecular Pathways: Beta-Adrenergic Signaling in Cancer [作者：Cole, SW; Sood, AK,期刊：Clinical Cancer Research, 页码：1201-1206 , 文章类型： Article，,卷期：2012年18-5] Beta-adrenergic signaling has been found to regulate multiple cellular processes that contribute to the initiation and progression of cancer, including inflammation, angiogenesis, apoptosis/anoikis, cell motility and tra... Molecular Pathways: Hypoxia Response in Immune Cells Fighting or Promoting Cancer [作者：Palazon, A; Aragones, J; Morales-Kastresana, A; de Landazuri, MO; Melero, I,期刊：Clinical Cancer Research, 页码：1207-1213 , 文章类型： Article，,卷期：2012年18-5] Both malignant and stromal components in tumors are influenced by the physiologic conditions of the microenvironment. Hypoxia is a prominent feature of solid tumors as a result of defective vascularization and intense me... Here, There Be Dragons: Charting Autophagy-Related Alterations in Human Tumors [作者：Lebovitz, CB; Bortnik, SB; Gorski, SM,期刊：Clinical Cancer Research, 页码：1214-1226 , 文章类型： Review，,卷期：2012年18-5] Macroautophagy (or autophagy) is a catabolic cellular process that is both homeostatic and stress adaptive. Normal cells rely on basal levels of autophagy to maintain cellular integrity (via turnover of long-lived protei... Activation of PI3K Signaling in Merkel Cell Carcinoma [作者：Nardi, V; Song, Y; Santamaria-Barria, JA; Cosper, AK; Lam, Q; Faber, AC; Boland, GM; Yeap, BY; Bergethon, K; Scialabba, VL; Tsao, H; Settleman, J; Ryan, DP; Borger, DR; Bhan, AK; Hoang, MP; Iafrate, AJ; Cusack, JC; Engelman, JA; Dias-Santagata, D,期刊：Clinical Cancer Research, 页码：1227-1236 , 文章类型： Article，,卷期：2012年18-5] Purpose: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine tumor, often metastatic at presentation, for which current chemotherapeutic regimens are largely ineffective. As its pathogenesis is still un... Infiltration of Lynch Colorectal Cancers by Activated Immune Cells Associates with Early Staging of the Primary Tumor and Absence of Lymph Node Metastases [作者：de Miranda, NFCC; Goudkade, D; Jordanova, ES; Tops, CMJ; Hes, FJ; Vasen, HFA; van Wezel, T; Morreau, H,期刊：Clinical Cancer Research, 页码：1237-1245 , 文章类型： Article，,卷期：2012年18-5] Purpose: Lynch syndrome colorectal cancers often lose human leukocyte antigen (HLA) class I expression. The outgrowth of clones with immune evasive phenotypes is thought to be positively selected by the action of cytotox... HDL of Patients with Type 2 Diabetes Mellitus Elevates the Capability of Promoting Breast Cancer Metastasis [作者：Pan, B; Ren, H; He, YB; Lv, XF; Ma, YJ; Li, J; Huang, L; Yu, BQ; Kong, J; Niu, CG; Zhang, YY; Sun, WB; Zheng, LM,期刊：Clinical Cancer Research, 页码：1246-1256 , 文章类型： Article，,卷期：2012年18-5] Purpose: Epidemiologic studies suggested complicated associations between type 2 diabetes mellitus and breast cancer. High-density lipoprotein (HDL) is inversely associated with the risk and mortality of breast cancer. O... Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival [作者：Gubanova, E; Brown, B; Ivanov, SV; Helleday, T; Mills, GB; Yarbrough, WG; Issaeva, N,期刊：Clinical Cancer Research, 页码：1257-1267 , 文章类型： Article，,卷期：2012年18-5] Purpose: Human papillomavirus (HPV) is linked with a subset of head and neck squamous cell carcinomas (HNSCC). HPV-positive HNSCCs show a better prognosis than HPV-negative HNSCCs, which may be explained by sensitivity o... Telomestatin Impairs Glioma Stem Cell Survival and Growth through the Disruption of Telomeric G-Quadruplex and Inhibition of the Proto-oncogene, c-Myb [作者：Miyazaki, T; Pan, Y; Joshi, K; Purohit, D; Hu, B; Demir, H; Mazumder, S; Okabe, S; Yamori, T; Viapiano, M; Shin-ya, K; Seimiya, H; Nakano, I,期刊：Clinical Cancer Research, 页码：1268-1280 , 文章类型： Article，,卷期：2012年18-5] Purpose: Glioma stem cells (GSC) are a critical therapeutic target of glioblastoma multiforme (GBM). Experimental Design: The effects of a G-quadruplex ligand, telomestatin, were evaluated using patient-derived GSCs, non... SKI-606, an Src Inhibitor, Reduces Tumor Growth, Invasion, and Distant Metastasis in a Mouse Model of Thyroid Cancer [作者：Kim, WG; Guigon, CJ; Fozzatti, L; Park, JW; Lu, CX; Willingham, MC; Cheng, SY,期刊：Clinical Cancer Research, 页码：1281-1290 , 文章类型： Article，,卷期：2012年18-5] Purpose: Src is overexpressed or hyperactivated in a variety of human cancers, including thyroid carcinoma. Src is a central mediator in multiple signaling pathways that are important in oncogenesis and cancer progressio... Polymeric Nanoparticle-Encapsulated Hedgehog Pathway Inhibitor HPI-1 (NanoHHI) Inhibits Systemic Metastases in an Orthotopic Model of Human Hepatocellular Carcinoma [作者：Xu, Y; Chenna, V; Hu, CX; Sun, HX; Khan, M; Bai, HB; Yang, XR; Zhu, QF; Sun, YF; Maitra, A; Fan, J; Anders, RA,期刊：Clinical Cancer Research, 页码：1291-1302 , 文章类型： Article，,卷期：2012年18-5] [F-18] FLT-PET Imaging Does Not Always "Light Up" Proliferating Tumor Cells [作者：Zhang, CC; Yan, ZM; Li, WL; Kuszpit, K; Painter, CL; Zhang, Q; Lappin, PB; Nichols, T; Lira, ME; Affolter, T; Fahey, NR; Cullinane, C; Spilker, M; Zasadny, K; O'Brien, P; Buckman, D; Wong, A; Christensen, JG,期刊：Clinical Cancer Research, 页码：1303-1312 , 文章类型： Article，,卷期：2012年18-5] Purpose: [F-18] FLT (3'-Fluoro-3' deoxythymidine)-PET imaging was proposed as a tool for measuring in vivo tumor cell proliferation. The aim of this article was to validate the use of [F-18] FLT-PET imaging for measuring... Epidermal Growth Factor Receptor Protein Detection in Head and Neck Cancer Patients: A Many-Faceted Picture [作者：Thariat, J; Etienne-Grimaldi, MC; Grall, D; Bensadoun, RJ; Cayre, A; Penault-Llorca, F; Veracini, L; Francoual, M; Formento, JL; Dassonville, O; De Raucourt, D; Geoffrois, L; Giraud, P; Racadot, S; Moriniere, S; Milano, G; Van Obberghen-Schilling, E,期刊：Clinical Cancer Research, 页码：1313-1322 , 文章类型： Article，,卷期：2012年18-5] Purpose: Epidermal growth factor receptor (EGFR) overexpression is associated with poor prognosis in head and neck squamous cell carcinoma (HNSCC). Despite intensive biomarker studies, a consensual method for assessing E... Combination of a Novel Gene Expression Signature with a Clinical Nomogram Improves the Prediction of Survival in High-Risk Bladder Cancer [作者：Riester, M; Taylor, JM; Feifer, A; Koppie, T; Rosenberg, JE; Downey, RJ; Bochner, BH; Michor, F,期刊：Clinical Cancer Research, 页码：1323-1333 , 文章类型： Article，,卷期：2012年18-5] Purpose: We aimed to validate and improve prognostic signatures for high-risk urothelial carcinoma of the bladder. Experimental Design: We evaluated microarray data from 93 patients with bladder cancer managed by radical... Copy Number Losses Define Subgroups of Dedifferentiated Liposarcoma with Poor Prognosis and Genomic Instability [作者：Crago, AM; Socci, ND; DeCarolis, P; O'Connor, R; Taylor, BS; Qin, LX; Antonescu, CR; Singer, S,期刊：Clinical Cancer Research, 页码：1334-1340 , 文章类型： Article，,卷期：2012年18-5] Purpose: Molecular events underlying progression of well-differentiated liposarcoma (WDLS) to dedifferentiated liposarcoma (DDLS) are poorly defined. This study sought to identify copy number alterations (CNA) associated...