- Age-Related Vascular Pathology in Transgenic Mice Expressing Presenilin 1-Associated Familial Alzheimer's Disease Mutations
[作者:Sosa, MAG; De Gasperi, R; Rocher, AB; Wang, ACJ; Janssen, WGM; Flores, T; Perez, GM; Schmeidler, J; Dickstein, DL; Hof, PR; Elder, GA,期刊:American Journal of Pathology, 页码:353-368 , 文章类型: Article,,卷期:2010年176-1]
- Mutations in the presenilin 1 (PS1) gene are the most commonly recognized cause of familial Alzheimer's disease (FAD). Besides senile plaques, neurofibrillary tangles, and neuronal loss, Alzheimer's disease (AD) is also ...
- Differential Effects of Myocilin and Optineurin, Two Glaucoma Genes, on Neurite Outgrowth
[作者:Koga, T; Shen, X; Park, JS; Qiu, Y; Park, BC; Shyam, R; Yue, BYJT,期刊:American Journal of Pathology, 页码:343-352 , 文章类型: Article,,卷期:2010年176-1]
- Myocilin and optineurin are two genes linked to glaucoma, a major blinding disease characterized by progressive loss of retinal ganglion cells (RGCs) and their axons. To investigate the effects of force-expressed wild-ty...
- Multi-Step Aberrant CpG Island Hyper-Methylation Is Associated with the Progression of Adult T-Cell Leukemia/Lymphoma
[作者:Sato, H; Oka, T; Shinnou, Y; Kondo, T; Washio, K; Takano, M; Takata, K; Morito, T; Huang, XG; Tamura, M; Kitamura, Y; Ohara, N; Ouchida, M; Ohshima, K; Shimizu, K; Tanimoto, M; Takahashi, K; Matsuoka, M; Utsunomiya, A; Yoshino, T,期刊:American Journal of Pathology, 页码:402-415 , 文章类型: Article,,卷期:2010年176-1]
- Aberrant CpG island methylation contributes to the pathogenesis of various malignancies. However, little is known about the association of epigenetic abnormalities with multistep tumorigenic events in adult T cell leukem...
- Cellular Plasticity of Inflammatory Myeloid Cells in the Peritoneal Foreign Body Response
[作者:Mooney, JE; Rolfe, BE; Osborne, GW; Sester, DP; van Rooijen, N; Campbell, GR; Hume, DA; Campbell, JH,期刊:American Journal of Pathology, 页码:369-380 , 文章类型: Article,,卷期:2010年176-1]
- Implantation of sterile foreign objects in the peritoneal cavity of an animal initiates an inflammatory response and results in encapsulation of the objects by bone marrow-derived cells. Over time, a multilayered tissue ...
- CrkII Transgene Induces Atypical Mammary Gland Development and Tumorigenesis
[作者:Fathers, KE; Rodrigues, S; Zuo, DM; Murthy, IV; Hallett, M; Cardiff, R; Park, M,期刊:American Journal of Pathology, 页码:446-460 , 文章类型: Article,,卷期:2010年176-1]
The v-Crk protein was originally isolated as the oncogene fusion product of the CT10 chicken retrovirus. Cellular homologues of v-Crk include Crk, which encodes two alternatively spliced proteins (CrkI and CrkII), and...
- Cross-Talk between Vascular Endothelial Growth Factor and Matrix Metalloproteinases in the Induction of Neovascularization in Vivo
[作者:Ebrahem, Q; Chaurasia, SS; Vasanji, A; Qi, JH; Klenotic, PA; Cutler, A; Asosingh, K; Erzurum, S; Anand-Apte, B,期刊:American Journal of Pathology, 页码:496-503 , 文章类型: Article,,卷期:2010年176-1]
- Matrix metalloproteinases (MMPs), a specialized group of enzymes capable of proteolytically degrading extracellular matrix proteins, have been postulated to play an important role in angiogenesis. It has been suggested t...
- MYC High Level Gene Amplification Is a Distinctive Feature of Angiosarcomas after Irradiation or Chronic Lymphedema
[作者:Manner, J; Radlwimmer, B; Hohenberger, P; Mossinger, K; Kuffer, S; Sauer, C; Belharazem, D; Zettl, A; Coindre, JM; Hallermann, C; Hartmann, JT; Katenkamp, D; Katenkamp, K; Schoffski, P; Sciot, R; Wozniak, A; Lichter, P; Marx, A; Strobel, P,期刊:American Journal of Pathology, 页码:34-39 , 文章类型: Article,,卷期:2010年176-1]
- Angiosarcomas (AS) are rare vascular malignancies that arise either de novo as primary tumors or secondary to irradiation or chronic lymphedema. The cytogenetics of angiosarcomas are poorly characterized. We applied arra...
- Epidermal Smad4 Deletion Results in Aberrant Wound Healing
[作者:Owens, P; Engelking, E; Han, GW; Haeger, SM; Wang, XJ,期刊:American Journal of Pathology, 页码:122-133 , 文章类型: Article,,卷期:2010年176-1]
- In the present study, we assessed the role of Smad4, a component of the transforming growth factor-beta signaling pathway, in cutaneous wound repair. Interestingly, when Smad4 was deleted in the epidermis, several defect...
- Tissue Inhibitor of Metalloproteinases 3 Regulates Resolution of Inflammation following Acute Lung Injury
[作者:Gill, SE; Huizar, I; Bench, EM; Sussman, SW; Wang, Y; Khokha, R; Parks, WC,期刊:American Journal of Pathology, 页码:64-73 , 文章类型: Article,,卷期:2010年176-1]
- Tissue inhibitor of metalloproteinases 3 (TIMP3) inhibits not only matrix metalloproteinases but also a disintegrin and metalloproteinase domain family members and thus contributes to controlling diverse processes mediat...
- Tumor Suppressor Scribble Regulates Assembly of Tight Junctions in the Intestinal Epithelium
[作者:Ivanov, AI; Young, C; Den Beste, K; Capaldo, CT; Humbert, PO; Brennwald, P; Parkos, CA; Nusrat, A,期刊:American Journal of Pathology, 页码:134-145 , 文章类型: Article,,卷期:2010年176-1]
- Formation of the epithelial barrier and apico-basal cell polarity represent two characteristics and mutually dependent features of differentiated epithelial monolayers. They are controlled by special adhesive structures,...
- Pigment Epithelium-Derived Factor Inhibits Lysosomal Degradation of Bcl-xL and Apoptosis in HepG2 cells
[作者:Kawaguchi, T; Yamagishi, S; Itou, M; Okuda, K; Sumie, S; Kuromatsu, R; Sakata, M; Abe, M; Taniguchi, E; Koga, H; Harada, M; Ueno, T; Sata, M,期刊:American Journal of Pathology, 页码:168-176 , 文章类型: Article,,卷期:2010年176-1]
- Pigment epithelium-derived factor (PEDF) has several biological actions on tumor cells, but its effects are cell-type dependent. The aim of this study was to examine the pathophysiological role of PEDF in hepatocellular ...
- Initiation of Acquired Immunity in the Lungs of Mice Lacking Lymph Nodes after Infection with Aerosolized Mycobacterium tuberculosis
[作者:Kashino, SS; Vallerskog, T; Martens, G; Troudt, J; Keyser, A; Taylor, J; Izzo, A; Kornfeld, H; Campos-Neto, A,期刊:American Journal of Pathology, 页码:198-204 , 文章类型: Article,,卷期:2010年176-1]
- Recent evidence points to lung draining lymph nodes as the site that initiates the immune response in mice infected with aerosolized Mycobacterium tuberculosis. Here we expanded these studies and showed that infection of...
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