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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共55条记录   Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase [作者：SCHORMANN NORBERT; VELU SADANANDAN E; MURUGESAN SRINIVASAN; SENKOVICH OLGA; WALKER KIERA; CHENNA BALA C; SHINKRE BIDHAN; DESAI AMAR; CHATTOPADHYAY DEBASISH,期刊：Bioorganic & Medicinal Chemistry, 页码：4056-4066 , 文章类型： Article，,卷期：2010年18-11] Dihydrofolate reductase (DHFR) of the parasite Trypanosoma cruzi (T. cruzi) is a potential target for developing drugs to treat Chagas' disease. We have undertaken a detailed structure-activity study of this enzyme. We r... Self-association of cyclic oligonucleotides through G:T:G:T minor groove tetrads [作者：VILADOMS JULIA; ESCAJA NURIA; PEDROSO ENRIQUE; GONZALEZ CARLOS,期刊：Bioorganic & Medicinal Chemistry, 页码：4067-4073 , 文章类型： Article，,卷期：2010年18-11] Minor groove aligned tetrads resulting from the association of Watson-Crick base pairs stabilize a distinct class of four-stranded DNA structures, different from G-quadruplexes or i-motifs. These tetrads can be formed by... Analogs of zanamivir with modified C4-substituents as the inhibitors against the group-1 neuraminidases of influenza viruses [作者：WEN WENHSIEN; WANG SHIYUN; TSAI KENGCHANG; CHENG YIHSHYUN E; YANG ANSUEI; FANG JIMMIN; WONG CHIHUEY,期刊：Bioorganic & Medicinal Chemistry, 页码：4074-4084 , 文章类型： Article，,卷期：2010年18-11] Unlike the group-2 neuraminidase, the group-1 neuraminidase of influenza virus possesses a flexible loop (the 150-loop) and a cavity (the 150-cavity) adjacent to the active site, and renders a conformational change from ... Characterization of 4-methyl-2-oxo-1,2-dihydroquinolin-6-yl acetate as an effective antiplatelet agent [作者：PRIYA NIVEDITA; GUPTA ANJALI; CHAND KARAM; SINGH PRABHJOT; KATHURIA ABHA; RAJ HANUMANTHARAO G; PARMAR VIRINDER S; SHARMA SUNIL K,期刊：Bioorganic & Medicinal Chemistry, 页码：4085-4094 , 文章类型： Article，,卷期：2010年18-11] We have studied earlier a membrane bound novel enzyme Acetoxy Drug: protein transacetylase identified as Calreticulin Transacetylase (CRTAase) that catalyzes the transfer of acetyl groups from polyphenolic acetates (PAs)... Synthesis and NMDA receptor affinity of fluorinated dioxadrol analogues [作者：BANERJEE ASHUTOSH; SCHEPMANN DIRK; WUENSCH BERNHARD,期刊：Bioorganic & Medicinal Chemistry, 页码：4095-4102 , 文章类型： Article，,卷期：2010年18-11] A series of dioxadrol analogues with fluorine substituents in position 4 of the piperidine ring has been synthesized and pharmacologically evaluated. The key step in the synthesis was the fluorination of diastereomeric p... On the inhibition of histone deacetylase 8 [作者：ESTIU GUILLERMINA; WEST NATHAN; MAZITSCHEK RALPH; GREENBERG EDWARD; BRADNER JAMES E; WIEST OLAF,期刊：Bioorganic & Medicinal Chemistry, 页码：4103-4110 , 文章类型： Article，,卷期：2010年18-11] Histone deacetylases are key regulators of gene expression and have recently emerged as important therapeutic targets for cancer and a growing number of non-malignant diseases. Many widely studied inhibitors of HDACs suc... Dendritic chain reaction: Responsive release of hydrogen peroxide upon generation and enzymatic oxidation of methanol [作者：AVITALSHMILOVICI MICHAL; SHABAT DORON,期刊：Bioorganic & Medicinal Chemistry, 页码：3643-3647 , 文章类型： Article，,卷期：2010年18-11] Signal amplification dramatically increases the sensitivity of diagnostic methods. Recently, we introduced a new technique for signal amplification that uses a distinctive dendritic chain reaction (DCR) to generate expon... Total synthesis of (+)-crocacin C [作者：SIRASANI GOPAL; PAUL TAPAS; ANDRADE RODRIGO B,期刊：Bioorganic & Medicinal Chemistry, 页码：3648-3655 , 文章类型： Article，,卷期：2010年18-11] Two approaches toward the total synthesis of cytotoxic polyketide natural product (+)-crocacin C (1) are described. The first approach, which was ultimately unsuccessful, was replaced altogether with a second that afford... Hybrids of sugars and aromatics: A Pd-catalyzed modular approach to chromans and isochromans [作者：LEIBELING MARKUS; KOESTER DENNIS C; PAWLICZEK MARTIN; KRATZERT DANIEL; DITTRICH BIRGER; WERZ DANIEL B,期刊：Bioorganic & Medicinal Chemistry, 页码：3656-3667 , 文章类型： Article，,卷期：2010年18-11] Herein we describe the synthesis of highly substituted chromans and isochromans using carbohydrates as starting materials. The key step of our synthetic approach is the annelation of the benzene moiety via a highly effic... Synthesis of an alpha-kojibiosyl substituted glycerol teichoic acid hexamer [作者：HOGENDORF WOUTER F J; VAN DEN BOS LEENDERT J; OVERKLEEFT HERMAN S; CODEE JEROEN D C; VAN DER MAREL GIJSBERT A,期刊：Bioorganic & Medicinal Chemistry, 页码：3668-3678 , 文章类型： Article，,卷期：2010年18-11] In this paper the synthesis of an Enterococcus Faecalis teichoic acid (TA) hexamer is presented. The key kojibiosyl-glycerol phosphoramidite building block was obtained by condensation of thioglucose donors, provided wit... Acidic and basic deprotection strategies of borane-protected phosphinothioesters for the traceless Staudinger ligation [作者：MUEHLBERG MICHAELA; JARADAT DASAN M M; KLEINEWEISCHEDE ROLF; PAPP ILONA; DECHTRIRAT DECHA; MUTH SILVIA; BRONCEL MALGORZATA; HACKENBERGER CHRISTIAN P R,期刊：Bioorganic & Medicinal Chemistry, 页码：3679-3686 , 文章类型： Article，,卷期：2010年18-11] The traceless Staudinger ligation has recently found various applications in the field of peptide synthesis and modification, including immobilization and cyclization strategies. In this report, we utilize the traceless ... Synthesis of the lipoteichoic acid of the Streptococcus species DSM 8747 [作者：QIAO YAN; LINDNER BUKO; ZAEHRINGER ULRICH; TRUOG PETER; SCHMIDT RICHARD R,期刊：Bioorganic & Medicinal Chemistry, 页码：3696-3702 , 文章类型： Article，,卷期：2010年18-11] The lipoteichoic acid (LTA) of the Streptococcus species DSM 8747 consists of a beta-D-galactofuranosyl diacylglycerol moiety (with different acyl groups) that is linked via 6-O to a poly(glycerophosphate) backbone; abou... Multiple glycosylation of de novo designed alpha-helical coiled coil peptides [作者：FALENSKI JESSICA A; GERLING ULLA I M; KOKSCH BEATE,期刊：Bioorganic & Medicinal Chemistry, 页码：3703-3706 , 文章类型： Article，,卷期：2010年18-11] The aim of this study was to investigate the influence of multiple O-glycosylation in alpha-helical coiled coil peptides on the folding and stability. For this purpose we systematically incorporated one to six beta-galac... Effects of frozen conditions on stereoselectivity and velocity of O-glycosylation reactions [作者：ISHIWATA AKIHIRO; SAKURAI AYAKA; DUERR KATHARINA; ITO YUKISHIGE,期刊：Bioorganic & Medicinal Chemistry, 页码：3687-3695 , 文章类型： Article，,卷期：2010年18-11] Rate acceleration of O-glycosylation had been observed in p-xylene under frozen conditions, when thioglycosides were activated by methyl trifluoromethane sulfonate. Curiously, significant perturbation of stereoselectivit... Flow chemistry using milli- and microstructured reactors-From conventional to novel process windows [作者：ILLG TOBIAS; LOEB PATRICK; HESSEL VOLKER,期刊：Bioorganic & Medicinal Chemistry, 页码：3707-3719 , 文章类型： Article，,卷期：2010年18-11] The terminology Novel Process Window unites different methods to improve existing processes by applying unconventional and harsh process conditions like: process routes at much elevated pressure, much elevated temperatur... Synthesis and binding analysis of unique AG2 pentasaccharide to human Siglec-2 using NMR techniques [作者：HANASHIMA SHINYA; SATO KENICHI; NAITO YUKO; TAKEMATSU HIROMU; KOZUTSUMI YASUNORI; ITO YUKISHIGE; YAMAGUCHI YOSHIKI,期刊：Bioorganic & Medicinal Chemistry, 页码：3720-3725 , 文章类型： Article，,卷期：2010年18-11] Siglec-2 is a mammalian sialic acid binding protein expressed on B-cell surfaces and is involved in the modulation of B-cell mediated immune response. We synthesized a unique starfish ganglioside, AG2 pentasaccharide Gal...