- Immune responses of healthy subjects to a single dose of intramuscular inactivated influenza A/Vietnam/1203/2004 (H5N1) vaccine after priming with an antigenic variant
[作者:Goji, NA; Nolan, C; Hill, H; Wolff, M; Noah, DL; Williams, TB; Rowe, T; Treanor, JJ,期刊:Journal of Infectious Diseases, 页码:635-641 , 文章类型: Article,,卷期:2008年198-5]
- Background. We administered a single dose of influenza A/Vietnam/1203/2004 (H5N1, clade 1) vaccine to subjects who had received 2 doses of influenza A/Hong Kong/156/1997 (H5N1, clade 0) vaccine in 1998.Methods. Thirty-se...
- An adjuvanted, low-dose, pandemic influenza a (H5N1) vaccine candidate is safe, immunogenic, and induces cross-reactive immune responses in healthy adults
[作者:Levie, K; Leroux-Roels, I; Hoppenbrouwers, K; Kervyn, AD; Vandermeulen, C; Forgus, S; Leroux-Roels, G; Pichon, S; Kusters, I,期刊:Journal of Infectious Diseases, 页码:642-649 , 文章类型: Article,,卷期:2008年198-5]
- Background. To protect a naive global population against pandemic influenza, pandemic vaccines should be effective at low antigen doses, because of limited manufacturing capacity.Methods. In a multicenter, randomized, bl...
- Intradermal influenza vaccine administered using a new microinjection system produces superior immunogenicity in elderly adults: A randomized controlled trial
[作者:Holland, D; Booy, R; De Looze, F; Eizenberg, P; McDonald, J; Karrasch, J; McKeirnan, M; Salem, H; Mills, G; Reid, J; Weber, F; Saville, M,期刊:Journal of Infectious Diseases, 页码:650-658 , 文章类型: Article,,卷期:2008年198-5]
- Background. Enhanced influenza vaccines are needed to provide improved protection for elderly individuals. The intradermal vaccination route was hypothesized to provide immunogenicity superior to that provided by the int...
- A new humanized mouse model of Epstein-Barr virus infection that reproduces persistent infection, lymphoproliferative disorder, and cell-mediated and humoral immune responses
[作者:Yajima, M; Imadome, K; Nakagawa, A; Watanabe, S; Terashima, K; Nakamura, H; Ito, M; Shimizu, N; Honda, M; Yamamoto, N; Fujiwara, S,期刊:Journal of Infectious Diseases, 页码:673-682 , 文章类型: Article,,卷期:2008年198-5]
- The functional human immune system, including T, B, and natural killer lymphocytes, is reconstituted in NOD/Shi-scid/IL-2R gamma(null)(NOG) mice that receive hematopoietic stem cell transplants. Here, we show that these ...
- Mucosal immunity in healthy adults after parenteral vaccination with outer-membrane vesicles from Neisseria meningitidis serogroup B
[作者:Davenport, V; Groves, E; Horton, RE; Hobbs, CG; Guthrie, T; Findlow, J; Borrow, R; Naess, LM; Oster, P; Heyderman, RS; Williams, NA,期刊:Journal of Infectious Diseases, 页码:731-740 , 文章类型: Article,,卷期:2008年198-5]
- Background. Nasopharyngeal carriage of meningococcus or related species leads to protective immunity in adolescence or early adulthood. This natural immunity is associated with mucosal and systemic T cell memory. Whether...
- Variation in the major surface glycoprotein genes in Pneumocystis jirovecii
[作者:Kutty, G; Maldarelli, F; Achaz, G; Kovacs, JA,期刊:Journal of Infectious Diseases, 页码:741-749 , 文章类型: Article,,卷期:2008年198-5]
- The genome of Pneumocystis, which causes life-threatening pneumonia in immunosuppressed patients, contains a multicopy gene family that encodes the major surface glycoprotein (Msg). Pneumocystis can vary the expressed Ms...
- Deficiency of alpha 7 cholinergic receptors facilitates bacterial clearance in Escherichia coli peritonitis
[作者:Giebelen, IAJ; Le Moine, A; van den Pangaart, PS; Sadis, C; Goldman, M; Florquin, S; van der Poll, T,期刊:Journal of Infectious Diseases, 页码:750-757 , 文章类型: Article,,卷期:2008年198-5]
- Background. The efferent vagus nerve can inhibit inflammation via interaction between acetylcholine and alpha 7 cholinergic receptors.Methods. To determine the role played by alpha 7 receptors in antibacterial defense, p...
- Liposome delivery of Chlamydia muridarum major outer membrane protein primes a Th1 response that protects against genital chlamydial infection in a mouse model
[作者:Hansen, J; Jensen, KT; Follmann, F; Agger, EM; Theisen, M; Andersen, P,期刊:Journal of Infectious Diseases, 页码:758-767 , 文章类型: Article,,卷期:2008年198-5]
- Background. Immunity to chlamydia is thought to rely on interferon (IFN)-gamma-secreting T helper cells type 1 (Th1) with an additional effect of secreted antibodies. A need for Th1-polarizing adjuvants in experimental c...
- Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria
[作者:Leoratti, FMS; Farias, L; Alves, FP; Suarez-Mutis, MC; Coura, JR; Kalil, J; Camargo, EP; Moraes, SL; Ramasawmy, R,期刊:Journal of Infectious Diseases, 页码:772-780 , 文章类型: Article,,卷期:2008年198-5]
- Background. Malaria is one of the most significant infectious diseases in the world and is responsible for a large proportion of infant deaths. Toll-like receptors (TLRs), key components of innate immunity, are central t...
- Experimental expansion of the regulatory T cell population increases resistance to African trypanosomiasis
[作者:Guilliams, M; Bosschaerts, T; Herin, M; Hunig, T; Loi, P; Flamand, V; De Baetselier, P; Beschin, A,期刊:Journal of Infectious Diseases, 页码:781-791 , 文章类型: Article,,卷期:2008年198-5]
- Inflammatory responses mounted to eliminate parasites can be lethal if not counterbalanced by regulatory responses protecting the host from collateral tissue damage. Here, we show that the maintained inflammation associa...
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