- Sickle cell trait is associated with a delayed onset of malaria: Implications for time-to-event analysis in clinical studies of malaria
[作者:Crompton, PD; Traore, B; Kayentao, K; Doumbo, S; Ongoiba, A; Diakite, SAS; Krause, MA; Doumtabe, D; Kone, Y; Weiss, G; Huang, CY; Doumbia, S; Guindo, A; Fairhurst, RM; Miller, LH; Pierce, SK; Doumbo, OK,期刊:Journal of Infectious Diseases, 页码:1265-1275 , 文章类型: Article,,卷期:2008年198-9]
- Background. The World Health Organization (WHO) recently recommended that the time to first malaria episode serve as the primary end point in phase III malaria vaccine trials-the first of which will be held in Africa. Al...
- Evaluation of the clinical significance of homB, a novel candidate marker of Helicobacter pylori strains associated with peptic ulcer disease
[作者:Oleastro, M; Cordeiro, R; Ferrand, J; Nunes, B; Lehours, P; Carvalho-Oliveira, I; Mendes, AI; Penque, D; Monteiro, L; Megraud, F; Menard, A,期刊:Journal of Infectious Diseases, 页码:1379-1387 , 文章类型: Article,,卷期:2008年198-9]
- Background. homB codes for a putative Helicobacter pylori outer membrane protein and has previously been associated with peptic ulcer disease (PUD) in children.Methods. A total of 190 H. pylori strains isolated from chil...
- CD14 impairs host defense against gram-negative sepsis caused by Burkholderia pseudomallei in mice
[作者:Wiersinga, WJ; de Vos, AF; Wieland, CW; Leendertse, M; Roelofs, JJTH; van der Poll, T,期刊:Journal of Infectious Diseases, 页码:1388-1397 , 文章类型: Article,,卷期:2008年198-9]
- Background. CD14 is a pattern-recognition receptor that can facilitate the presentation of bacterial components to either Toll-like receptor 2 (TLR2) or TLR4. We have recently shown that during melioidosis, a severe infe...
- Shiga toxin 2 affects the central nervous system through receptor globotriaosylceramide localized to neurons
[作者:Obata, F; Tohyama, K; Bonev, AD; Kolling, GL; Keepers, TR; Gross, LK; Nelson, MT; Sato, S; Obrig, TG,期刊:Journal of Infectious Diseases, 页码:1398-1406 , 文章类型: Article,,卷期:2008年198-9]
- Affinity-purified Shiga toxin (Stx) 2 given intraperitoneally to mice caused weight loss and hind-limb paralysis followed by death. Globotriaosylceramide (Gb3), the receptor for Stx2, was localized to neurons of the cent...
- Eukaryotic translation initiation factor 5A small interference RNA-liposome complexes reduce inflammation and increase survival in murine models of severe sepsis and acute lung injury
[作者:Moore, CC; Martin, EN; Lee, G; Taylor, C; Dondero, R; Reznikov, LL; Dinarello, C; Thompson, J; Scheld, WM,期刊:Journal of Infectious Diseases, 页码:1407-1414 , 文章类型: Article,,卷期:2008年198-9]
- Background. Many novel therapeutics have failed to reduce all-cause mortality associated with severe sepsis. Eukaryotic translation initiation factor 5A (eIF5A) is a regulator of apoptosis as well as inflammatory cell ac...
- Interleukin-12p70 deficiency increases survival and diminishes pathology in Trypanosoma congolense infection
[作者:Barkhuizen, M; Magez, S; Ryffel, B; Brombacher, F,期刊:Journal of Infectious Diseases, 页码:1284-1291 , 文章类型: Article,,卷期:2008年198-9]
- To determine the immunological role played by interleukin (IL)-12 family members in Trypanosoma congolense infection, IL-12p35(-/-), IL-12p40(-/-), and IL-12p35(/-/-)p40(-/-) mice were used. While the latter 2 strains la...
- Intracellular survival of Leishmania species that cause visceral leishmaniasis is significantly reduced by HIV-1 protease inhibitors
[作者:Trudel, N; Garg, R; Messier, N; Sundar, S; Ouellette, M; Tremblay, MJ,期刊:Journal of Infectious Diseases, 页码:1292-1299 , 文章类型: Article,,卷期:2008年198-9]
- Visceral leishmaniasis is now recognized as an opportunistic disease in individuals infected with human immunodeficiency virus type 1 (HIV-1). Although the usefulness of HIV-1 protease inhibitors (PIs) in antiretroviral ...
- In vitro evaluation of the protective role of human antibodies to West Nile virus (WNV) produced during natural WNV infection
[作者:Rios, M; Daniel, S; Dayton, AI; Wood, O; Hewlett, IK; Epstein, JS; Caglioti, S; Stramer, SL,期刊:Journal of Infectious Diseases, 页码:1300-1308 , 文章类型: Article,,卷期:2008年198-9]
- Background. West Nile virus (WNV) is endemic in the United States and transmissible by transfusion. Since 2003, the US blood supply has been screened by nucleic-acid tests (NAT) for WNV in minipools (MP-NAT) of 6 or 16 s...
- Safety and immunogenicity of an inactivated influenza A/H5N1 vaccine given with or without aluminum hydroxide to healthy adults: Results of a phase I-II randomized clinical trial
[作者:Keitel, WA; Campbell, JD; Treanor, JJ; Walter, EB; Patel, SM; He, F; Noah, DL; Hill, H,期刊:Journal of Infectious Diseases, 页码:1309-1316 , 文章类型: Article,,卷期:2008年198-9]
- Background. Dose-sparing strategies are being explored for vaccines against pandemic influenza. We evaluated the dose-sparing potential of aluminum hydroxide (AlOH) adjuvant.Methods. A total of 600 healthy subjects (age,...
- Comparison of the safety and immunogenicity of 2 respiratory syncytial virus (RSV) vaccines - Nonadjuvanted vaccine or vaccine adjuvanted with alum - Given concomitantly with influenza vaccine to high-risk elderly individuals
[作者:Falsey, AR; Walsh, EE; Capellan, J; Gravenstein, S; Zambon, M; Yau, E; Gorse, GJ; Edelman, R; Hayden, FG; McElhaney, JE; Neuzil, KM; Nichol, KL; Simoes, EAF; Wright, PF; Sales, VMP,期刊:Journal of Infectious Diseases, 页码:1317-1326 , 文章类型: Article,,卷期:2008年198-9]
- Background. Respiratory syncytial virus (RSV) has been recognized recently as an important adult pathogen.Methods. This randomized, double-blind, placebo-controlled study was designed to compare humoral responses to lice...
- Measurement of varicella-zoster virus (VZV) - specific cell-mediated immunity: Comparison between VZV skin test and interferon-gamma enzyme-linked immunospot assay
[作者:Sadaoka, K; Okamoto, S; Gomi, Y; Tanimoto, T; Ishikawa, T; Yoshikawa, T; Asano, Y; Yamanishi, K; Mori, Y,期刊:Journal of Infectious Diseases, 页码:1327-1333 , 文章类型: Article,,卷期:2008年198-9]
- Cell-mediated immunity (CMI) is critical for the prevention and control of varicella-zoster virus (VZV)-related disease. Toassess CMI to VZV, a varicella skin test and interferon-gamma enzyme-linked immunospot (ELISPOT) ...
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