- Trafficking of Superinfecting Mycobacterium Organisms into Established Granulomas Occurs in Mammals and Is Independent of the Erp and ESX-1 Mycobacterial Virulence Loci
[作者:Cosma, CL; Humbert, O; Sherman, DR; Ramakrishnan, L,期刊:Journal of Infectious Diseases, 页码:1851-1855 , 文章类型: Article,,卷期:2008年198-12]
- Although tuberculous granulomas, which are composed of infected macrophages and other immune cells, have long been considered impermeable structures, recent studies have shown that superinfecting Mycobacterium marinum tr...
- Myeloid Differentiation Primary Response Gene 88 Is Required for the Resolution of Otitis Media
[作者:Hernandez, M; Leichtle, A; Pak, K; Ebmeyer, J; Euteneuer, S; Obonyo, M; Guiney, DG; Webster, NJ; Broide, DH; Ryan, AF; Wasserman, SI,期刊:Journal of Infectious Diseases, 页码:1862-1869 , 文章类型: Article,,卷期:2008年198-12]
- Background. Signaling defects in the Toll-like receptor (TLR) pathway, such as interleukin-1 receptor-associated kinase 4 deficiency, highlight the prominence of TLR signaling in the defense against bacterial disease. Be...
- Effect of Praziquantel Treatment during Pregnancy on Cytokine Responses to Schistosome Antigens: Results of a Randomized, Placebo-Controlled Trial
[作者:Tweyongyere, R; Mawa, PA; Ngom-Wegi, S; Ndibazza, J; Duong, T; Vennervald, BJ; Dunne, DW; Katunguka-Rwakishaya, E; Elliott, AM,期刊:Journal of Infectious Diseases, 页码:1870-1879 , 文章类型: Article,,卷期:2008年198-12]
- Background. Praziquantel treatment of schistosomiasis boosts antischistosome responses, with type 2 helper T cell bias that may contribute to immunologically mediated killing and to protection against reinfection. Praziq...
- A Functional Single-Nucleotide Polymorphism in the CR1 Promoter Region Contributes to Protection against Cerebral Malaria
[作者:Teeranaipong, P; Ohashi, J; Patarapotikul, J; Kimura, R; Nuchnoi, P; Hananantachai, H; Naka, I; Putaporntip, C; Jongwutiwes, S; Tokunaga, K,期刊:Journal of Infectious Diseases, 页码:1880-1891 , 文章类型: Article,,卷期:2008年198-12]
- Background. Although the level of erythrocyte complement receptor type 1 (E-CR1) expression in patients with malaria has been extensively studied, whether the level of expression of E-CR1 is associated with severe malari...
- Imbalanced Distribution of GM Immunoglobulin Allotypes According to the Clinical Presentation of Plasmodium falciparum Malaria in Beninese Children
[作者:Migot-Nabias, F; Noukpo, JM; Guitard, E; Doritchamou, J; Garcia, A; Dugoujon, JM,期刊:Journal of Infectious Diseases, 页码:1892-1895 , 文章类型: Article,,卷期:2008年198-12]
- Selection pressure exerted by pathogens contributes to the persistence of polymorphisms in GM and KM allotypes, which are antigenic determinants of immunoglobulins. This study investigated the impact of GM and KM allotyp...
- Hepatitis C Virus (HCV)-Specific T Cell Responses in Injection Drug Users with Apparent Resistance to HCV Infection
[作者:Thurairajah, PH; Hegazy, D; Chokshi, S; Shaw, S; Demaine, A; Kaminski, ER; Naoumov, NV; Cramp, ME,期刊:Journal of Infectious Diseases, 页码:1749-1755 , 文章类型: Article,,卷期:2008年198-12]
- Background. Injection drug users (IDUs) are at risk of acquiring hepatitis C virus (HCV) infection. We have identified a cohort of long-term IDUs who remain uninfected by HCV despite high-risk behavior. We have categoriz...
- Highly Efficient JFH1-Based Cell-Culture System for Hepatitis C Virus Genotype 5a: Failure of Homologous Neutralizing-Antibody Treatment to Control Infection
[作者:Jensen, TB; Gottwein, JM; Scheel, TKH; Hoegh, AM; Eugen-Olsen, J; Bukh, J,期刊:Journal of Infectious Diseases, 页码:1756-1765 , 文章类型: Article,,卷期:2008年198-12]
- Background. Recently, a hepatitis C virus (HCV) cell-culture system was developed that employed strain JFH1 ( genotype 2a), and JFH1-based intra-and intergenotypic recombinants now permit functional studies of the struct...
- Alcohol Metabolism Increases the Replication of Hepatitis C Virus and Attenuates the Antiviral Action of Interferon
[作者:McCartney, EM; Semendric, L; Helbig, KJ; Hinze, S; Jones, B; Weinman, SA; Beard, MR,期刊:Journal of Infectious Diseases, 页码:1766-1775 , 文章类型: Article,,卷期:2008年198-12]
- The interactions between hepatitis C virus (HCV) and alcohol metabolism are not well understood. To determine the effect that alcohol metabolism has on HCV replication and the antiviral action of interferon (IFN), Huh-7 ...
- Macrophage Impairment Underlies Airway Occlusion in Primary Respiratory Syncytial Virus Bronchiolitis
[作者:Reed, JL; Brewah, YA; Delaney, T; Welliver, T; Burwell, T; Benjamin, E; Kuta, E; Kozhich, A; McKinney, L; Suzich, J; Kiener, PA; Avendano, L; Velozo, L; Humbles, A; Welliver, RC; Coyle, AJ,期刊:Journal of Infectious Diseases, 页码:1783-1793 , 文章类型: Article,,卷期:2008年198-12]
- Although respiratory syncytial virus (RSV) infection is the most important cause of bronchiolitis in infants, the pathogenesis of RSV disease is poorly described. We studied histopathologic changes in a panel of lung tis...
- Effect of Rosiglitazone on Peroxisome Proliferator-Activated Receptor gamma Gene Expression in Human Adipose Tissue Is Limited by Antiretroviral Drug-Induced Mitochondrial Dysfunction
[作者:Mallon, PWG; Sedwell, R; Rogers, G; Nolan, D; Unemori, P; Hoy, J; Samaras, K; Kelleher, A; Emery, S; Cooper, DA; Carr, A,期刊:Journal of Infectious Diseases, 页码:1794-1803 , 文章类型: Article,,卷期:2008年198-12]
- Background. Treatment of human immunodeficiency virus (HIV)-1 with thymidine-analogue nucleoside reverse-transcriptase inhibitors (tNRTIs) causes lipoatrophy, mitochondrial toxicity, and lower adipose tissue expression o...
- Herpes Simplex Virus (HSV)-Suppressive Therapy Decreases Plasma and Genital HIV-1 Levels in HSV-2/HIV-1 Coinfected Women: A Randomized, Placebo-Controlled, Cross-Over Trial
[作者:Baeten, JM; Strick, LB; Lucchetti, A; Whittington, WLH; Sanchez, J; Coombs, RW; Magaret, A; Wald, A; Corey, L; Celum, C,期刊:Journal of Infectious Diseases, 页码:1804-1808 , 文章类型: Article,,卷期:2008年198-12]
- A randomized cross-over trial of herpes simplex virus type 2 (HSV-2)-suppressive therapy (valacyclovir, 500 mg twice daily, or placebo for 8 weeks, a 2-week washout period, then the alternative therapy for 8 weeks) was c...
- Age- and Serotype-Specific Pediatric Invasive Pneumococcal Disease: Insights from Systematic Surveillance in Santiago, Chile, 1994-2007
[作者:Lagos, R; Munoz, A; San Martin, O; Maldonado, A; Hormazabal, JC; Blackwelder, WC; Levine, MM,期刊:Journal of Infectious Diseases, 页码:1809-1817 , 文章类型: Article,,卷期:2008年198-12]
- Background. We monitored pediatric invasive pneumococcal disease (IPD) in Santiago, Chile, from 1994 to 2007.Methods. Three related data sets were generated: (1) IPD cases requiring hospitalization, 1994-2007; (2) cases ...
- Differential Effects of Pneumococcal Vaccines against Serotypes 6A and 6C
[作者:Park, IH; Moore, MR; Treanor, JJ; Pelton, SI; Pilishvili, T; Beall, B; Shelly, MA; Mahon, BE; Nahm, MH,期刊:Journal of Infectious Diseases, 页码:1818-1822 , 文章类型: Article,,卷期:2008年198-12]
- Background. Because classic pneumococcal serotyping methods cannot distinguish between serotypes 6A and 6C, the effects of pneumococcal vaccines against serotype 6C are unknown. Pneumococcal vaccines contain serotype 6B ...
- Induction of CC and CXC Chemokines in Human Antigen-Presenting Dendritic Cells by the Pneumococcal Proteins Pneumolysin and CbpA, and the Role Played by Toll-Like Receptor 4, NF-kappa B, and Mitogen-Activated Protein Kinases
[作者:Bernatoniene, J; Zhang, QB; Dogan, S; Mitchell, TJ; Paton, JC; Finn, A,期刊:Journal of Infectious Diseases, 页码:1823-1833 , 文章类型: Article,,卷期:2008年198-12]
- Background. Choline-binding protein A (CbpA) and pneumolysin (Ply) can induce the expression and release of chemokines by human cells, which might modulate specific immune responses. In dendritic cells (DCs), such effect...
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