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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共7条记录   ELACYTARABINE Antimetabolite Oncolytic [作者：Burke, A; Swords, R; Kelly, K; Giles, FJ,期刊：Drugs of the Future, 页码：941-949 , 文章类型： Article，,卷期：2009年34-12] Cytarabine has long been an important component of standard chemotherapy for hematological malignancies. Investigations into the mechanism of resistance to this agent have led to new insights into the metabolism of cytar... OMECAMTIV MECARBIL Cardiac Myosin Activator Treatment of Heart Failure [作者：Tamargo, J; Lopez-Farre, A; Caballero, R; Delpon, E,期刊：Drugs of the Future, 页码：950-961 , 文章类型： Article，,卷期：2009年34-12] Positive inotropic agents are used in the treatment of heart failure. Intravenous inotropes (dopamine, dobutamine, milrinone) improve the hemodynamic and clinical status of acute decompensated chronic heart failure, but ... SATRAPLATIN DNA-Alkylating Agent Oncolytic Platinum Complex [作者：Sonpavde, G; Sternberg, CN,期刊：Drugs of the Future, 页码：962-968 , 文章类型： Article，,卷期：2009年34-12] Satraplatin is a third-generation, orally available platinum analogue which demonstrated a 33% reduction in the risk of progression in patients with metastatic castration-resistant prostate cancer (CRPC) following one pr... THERAPEUTIC PROSPECTS FOR SPINOCEREBELLAR ATAXIA TYPE 2 AND 3 [作者：Bezprozvanny, I; Klockgether, T,期刊：Drugs of the Future, 页码：991-999 , 文章类型： Article，,卷期：2009年34-12] Spinocerebellar ataxia type 2 (SCA2) and type 3 (SCA3) are autosomal-dominant neurodegenerotive disorders. SCA2 primarily affects cerebellar Purkinje neurons and SCA3 primarily affects dentate and pon tine nuclei and the... ENHANCING COGNITION IN NEUROLOGICAL DISORDERS: POTENTIAL USEFULNESS OF 5-HT6 ANTAGONISTS [作者：Wilson, C; Terry, AV,期刊：Drugs of the Future, 页码：969-975 , 文章类型： Review，,卷期：2009年34-12] It is widely recognized that cognitive dysfunction is among the most debilitating symptoms of many neuropsychiatric disorders, including Alzheimer's disease and schizophrenia. Accordingly, there is a critical need for ne... HEMATOPOIETIC GROWTH FACTORS: NOVEL THERAPEUTIC STRATEGY FOR ALZHEIMER'S DISEASE [作者：Rowe, A; Eberhard, J; Sanchez-Ramos, J,期刊：Drugs of the Future, 页码：977-989 , 文章类型： Review，,卷期：2009年34-12] The search for trophic factors that impact the degenerating nervous system has expanded beyond the classical neurotrophins. There is increasing recognition that hematopoietic growth factors (HGFs) have neurotrophic prope... THERAPEUTIC TARGETS FOR GAUCHER'S DISEASE [作者：Sorbera, LA; Sundaravinayagam, D; Dulsat, C; Rosa, E,期刊：Drugs of the Future, 页码：1001-1004 , 文章类型： Article，,卷期：2009年34-12] Gaucher's disease is an autosomal recessive lysosomal storage disorder caused by mutations in the gene encoding the enzyme glucosylceramidase. The physiological result is a deficiency in this enzyme and a consequent accu...