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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共23条记录   The N-Terminal Domain of the Escherichia coli PriA Helicase Contains Both the DNA- and Nucleotide-Binding Sites. Energetics of Domain-DNA Interactions and Allosteric Effect of the Nucleotide Cofactors [作者：Szymanski, MR; Bujalowski, PJ; Jezewska, MJ; Gmyrek, AM; Bujalowski, W,期刊：Biochemistry, 页码：9167-9183 , 文章类型： Article，,卷期：2011年50-43] Functional interactions of the Escherichia coli PriA helicase 181N-terminal domain with the DNA and nucleotide cofactors have been quantitatively examined. The isolated 181N-terminal domain forms a stable dimer in soluti... Inflammation Protein SAA2.2 Spontaneously Forms Marginally Stable Amyloid Fibrils at Physiological Temperature [作者：Ye, ZQ; Poueymiroy, DB; Aguilera, JJ; Srinivasan, S; Wang, Y; Serpell, LC; Colon, W,期刊：Biochemistry, 页码：9184-9191 , 文章类型： Article，,卷期：2011年50-43] For nearly four decades, the formation of amyloid fibrils by the inflammation-related protein serum amyloid A (SAA) has been pathologically linked to the disease amyloid A (AA) amyloidosis. However, here we show that the... Lipocalin Q83 Reveals a Dual Ligand Binding Mode with Potential Implications for the Functions of Siderocalins [作者：Coudevylle, N; Hoetzinger, M; Geist, L; Kontaxis, G; Hartl, M; Bister, K; Konrat, R,期刊：Biochemistry, 页码：9192-9199 , 文章类型： Article，,卷期：2011年50-43] Siderocalins are particular lipocalins that participate in the innate immune response by interfering with bacterial siderophore-mediated iron uptake. Additionally, siderocalins are involved in several physiological and p... Kinetic, Mechanistic, and Structural Modeling Studies of Truncated Wild-Type Leucine-Rich Repeat Kinase 2 and the G2019S Mutant [作者：Liu, M; Kang, S; Ray, S; Jackson, J; Zaitsev, AD; Gerber, SA; Cuny, GD; Glicksman, MA,期刊：Biochemistry, 页码：9399-9408 , 文章类型： Article，,卷期：2011年50-43] Leucine-rich repeat kinase 2 (LRRK2), a large and complex protein that possesses two enzymatic properties, kinase and GTPase, is one of the major genetic factors in Parkinson's disease (PD). Here, we characterize the kin... Revisiting Peptide Amphiphilicity for Membrane Pore Formation [作者：Lorin, A; Noel, M; Provencher, ME; Turcotte, V; Masson, C; Cardinal, S; Lague, P; Voyer, N; Auger, M,期刊：Biochemistry, 页码：9409-9420 , 文章类型： Article，,卷期：2011年50-43] It has previously been shown that an amphipathic de novo designed peptide made of 10 leucines and four phenylalanines substituted with crown ethers induces vesicle leakage without selectivity. To gain selectivity against... Length-Dependent Aggregation of Uninterrupted Polyalanine Peptides [作者：Bernacki, JP; Murphy, RM,期刊：Biochemistry, 页码：9200-9211 , 文章类型： Article，,卷期：2011年50-43] Polyalanine (polyA) is the third-most prevalent homopeptide repeat in eukaryotes, behind polyglutamine and polyasparagine. Abnormal expansion of the polyA repeat is linked to at least nine human diseases, and the disease... Evidence for Direct Binding between HetR from Anabaena sp PCC 7120 and PatS-5 [作者：Feldmann, EA; Ni, S; Sahu, ID; Mishler, CH; Risser, DD; Murakami, JL; Tom, SK; McCarrick, RM; Lorigan, GA; Tolbert, BS; Callahan, SM; Kennedy, MA,期刊：Biochemistry, 页码：9212-9224 , 文章类型： Article，,卷期：2011年50-43] HetR, master regulator of heterocyst differentiation in the filamentous cyanobacterium Anabaena sp. strain PCC 7120, stimulates heterocyst differentiation via transcriptional autoregulation and is negatively regulated by... Exploring Weak, Transient Protein-Protein Interactions in Crowded In Vivo Environments by In-Cell Nuclear Magnetic Resonance Spectroscopy [作者：Wang, QH; Zhuravleva, A; Gierasch, LM,期刊：Biochemistry, 页码：9225-9236 , 文章类型： Article，,卷期：2011年50-43] Biology relies on functional interplay of proteins in the crowded and heterogeneous environment inside cells, and functional protein interactions are often weak and transient. Thus, methods that preserve these interactio... Molecular Basis of the Cooperative Binding of Cu(I) and Cu(II) to the CopK Protein from Cupriavidus metallidurans CH34 [作者：Ash, MR; Chong, LX; Maher, MJ; Hinds, MG; Xiao, ZG; Wedd, AG,期刊：Biochemistry, 页码：9237-9247 , 文章类型： Article，,卷期：2011年50-43] The bacterium Cupriavidus metallidurans CH34 is resistant to high environmental concentrations of many metal ions. Upon copper challenge, it upregulates the periplasmic protein CopK (8.3 kDa). The function of CopK in the... Effects of Ammonia on the Structure of the Oxygen-Evolving Complex in Photosystem II As Revealed by Light-Induced FTIR Difference Spectroscopy [作者：Hou, LH; Wu, CM; Huang, HH; Chu, HA,期刊：Biochemistry, 页码：9248-9254 , 文章类型： Article，,卷期：2011年50-43] NH(3) is a structural analogue of substrate H(2)O and an inhibitor to the water oxidation reaction in photosystem II. To test whether or not NH(3) is able to replace substrate water molecules on the oxygen-evolving compl... Electron Transfer within Nitrogenase: Evidence for a Deficit-Spending Mechanism [作者：Danyal, K; Dean, DR; Hoffman, BM; Seefeldt, LC,期刊：Biochemistry, 页码：9255-9263 , 文章类型： Article，,卷期：2011年50-43] The reduction of substrates catalyzed by nitrogenase utilizes an electron transfer (ET) chain comprised of three metalloclusters distributed between the two component proteins, designated as the Fe protein and the MoFe p... Effects of the Association between the alpha-Subunit Thigh and the beta-Subunit EGF2 Domains on Integrin Activation and Signaling [作者：Wang, W; Jiang, Y; Wang, C; Luo, BH,期刊：Biochemistry, 页码：9264-9272 , 文章类型： Article，,卷期：2011年50-43] Integrin bidirectional signaling is mediated by conformational change. It has been shown that the separation of the alpha- and beta-subunit transmembrane/cytoplasmic tails and the lower legs is required for transmitting ... Hydrogen/Deuterium Exchange and Electron-Transfer Dissociation Mass Spectrometry Determine the Interface and Dynamics of Apolipoprotein E Oligomerization [作者：Huang, RYC; Garai, K; Frieden, C; Gross, ML,期刊：Biochemistry, 页码：9273-9282 , 文章类型： Article，,卷期：2011年50-43] Apolipoprotein E, a 34 kDa protein, plays a key role in triglyceride and cholesterol metabolism. Of the three common isoforms (ApoE2, -3, and -4), only ApoE4 is a risk factor for Alzheimer's disease. All three isoforms o... A Tale of Two Isomerases: Compact versus Extended Active Sites in Ketosteroid Isomerase and Phosphoglucose Isomerase [作者：Somarowthu, S; Brodkin, HR; D'Aquino, JA; Ringe, D; Ondrechen, MJ; Beuning, PJ,期刊：Biochemistry, 页码：9283-9295 , 文章类型： Article，,卷期：2011年50-43] Understanding the catalytic efficiency and specificity of enzymes is a fundamental question of major practical and conceptual importance in biochemistry. Although progress in biochemical and structural studies has enrich... Function of UreB in Klebsiella aerogenes Urease [作者：Carter, EL; Boer, JL; Farrugia, MA; Flugga, N; Towns, CL; Hausinger, RP,期刊：Biochemistry, 页码：9296-9308 , 文章类型： Article，,卷期：2011年50-43] Urease from Klebsiella aerogenes is composed of three subunits (UreA-UreB-UreC) that assemble into a (UreABC)(3) quaternary structure. UreC harbors the dinuclear nickel active site, whereas the functions of UreA and UreB... Antibiotic Selection by the Promiscuous Aminoglycoside Acetyltransferase-(3)-IIIb Is Thermodynamically Achieved through the Control of Solvent Rearrangement [作者：Norris, AL; Serpersu, EH,期刊：Biochemistry, 页码：9309-9317 , 文章类型： Article，,卷期：2011年50-43] The results presented here show the first known observation of opposite signs of change in heat capacity (Delta C(p)) of two structurally similar ligands binding to the same protein site. Neomycin and paromomycin are ami...