Background: Since the discovery of cannabinoid receptors and their endogenous ligands in early 1990s, the endocannabinoid system has been shown to play a vital role in several pathophysiological processes. It has been ta...
Background: The potential of exogenous stem cell or progenitor cell transplantation as a novel therapeutic strategy to address unmet medical needs is a vast and important area of investigation. A recent US patent has bee...
Importance of the field: PDE10A inhibition has generated much excitement as a potential novel mechanism for the treatment of the positive symptoms of schizophrenia. PDE10A is only '10 years old' as a drug discovery targe...
Importance of the field: Following FDA approval of vorinostat in 2006, several novel HDAC inhibitors (HDACis) have entered clinical trials, and there are numerous published patent applications claiming novel HDACis which...
Background: Migraine is a debilitating headache disorder which affects similar to 12% of the general population and is the cause of significant loss of productivity (i.e., lost time from work or school) for those afflict...
Background: Luteinizing hormone-releasing hormone (LH-RH) plays a central role in the vertebrate reproduction by regulating gonadal activity. Based on its binding to pituitary LH-RH receptors, as well as to LH-RH recepto...
Background: Transient receptor potential ankyrin 1 (TRPA1) has been revealed as a pivotal molecular entity in sensory biology, especially as a sensor of chemical irritants present in foods, atmospheric pollutants and neu...
Background: TGF-beta has been identified as a key factor in the progression of various diseases, in particular cancer and fibrosis. The signaling of TGF-beta can be modulated through three distinct strategies: using anti...