- New potential therapies for the treatment of antiphospholipid syndrome
[作者:Saha, AK; D'Cruz, D,期刊:Expert Opinion on Therapeutic Patents, 页码:13-22 , 文章类型: Review,,卷期:2009年19-1]
Background: Antiphospholipid syndrome (APS) is a disease that, untreated, can have catastropic consequences, primarily owing to uncontrolled thrombosis formation. At present, therapy is limited in the main to aspirin,...
- Recent patents regarding the discovery of small molecule CXCR4 antagonists
[作者:Mosley, CA; Wilson, LJ; Wiseman, JM; Skudlarek, JW; Liotta, DC,期刊:Expert Opinion on Therapeutic Patents, 页码:23-38 , 文章类型: Review,,卷期:2009年19-1]
Background: The chemokine receptors, CCR5 and CXCR4, are the primary co-receptors responsible for mediating HIV-1 cell entry. Small molecules that antagonize these receptors utilize a fundamentally different approach ...
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