- The Krebs Cycle and Mitochondrial Mass Are Early Victims of Endothelial Dysfunction Proteomic Approach
[作者：Addabbo, F; Ratliff, B; Park, HC; Kuo, MC; Ungvari, Z; Ciszar, A; Krasnikof, B; Sodhi, K; Zhang, F; Nasjletti, A; Goligorsky, MS,期刊：American Journal of Pathology, 页码：34-43 , 文章类型： Article，,卷期：2009年174-1]
- Endothelial cell dysfunction is associated with bio-available nitric oxide deficiency and an excessive generation of reactive oxygen species. We modeled this condition by chronically inhibiting nitric oxide generation wi...
- Adipose Tissue Sensitivity to Radiation Exposure
[作者：Poglio, S; Galvani, S; Bour, S; Andre, M; Prunet-Marcassus, B; Penicaud, L; Casteilla, L; Cousin, B,期刊：American Journal of Pathology, 页码：44-53 , 文章类型： Article，,卷期：2009年174-1]
- Treatment of cancer using radiation can be significantly compromised by the development of severe acute and late damage to normal tissue. Treatments that either reduce the risk and severity of damage or that facilitate t...
- Renal Ischemia-Induced Cholesterol Loading Transcription Factor Recruitment and Chromatin Remodeling along the HMG CoA Reductase Gene
[作者：Naito, M; Bomsztyk, K; Zager, RA,期刊：American Journal of Pathology, 页码：54-62 , 文章类型： Article，,卷期：2009年174-1]
- Acute kidney injury evokes renal tubular cholesterol synthesis. However, the factors during acute kidney injury that regulate HMG CoA reductase (HMGCR) activity, the rate-limiting step in cholesterol synthesis, have not ...
- The Protective Role of Per2 Against Carbon Tetrachloride-induced Hepatotoxicity
[作者：Chen, P; Li, CY; Pang, WQ; Zhao, Y; Dong, W; Wang, SM; Zhang, JF,期刊：American Journal of Pathology, 页码：63-70 , 文章类型： Article，,卷期：2009年174-1]
- Period 2 (Per2) is a key component of the core clock oscillator and is involved in regulating a number of different biological processes and pathways. Here we report that Per2 plays a protective role in carbon tetrachlor...
- DEK Proto-Oncogene Expression Interferes with the Normal Epithelial Differentiation Program
[作者：Wise-Draper, TM; Morreale, RJ; Morris, TA; Mintz-Cole, RA; Hoskii, EE; Balsitis, SJ; Husseinzadeh, N; Witte, DP; Wikenheiser-Brokamp, KA; Lambert, PF; Wells, SI,期刊：American Journal of Pathology, 页码：71-81 , 文章类型： Article，,卷期：2009年174-1]
- Overexpression of the DEK gene is associated with multiple human cancers, but its specific roles as a putative oncogene are not well defined. DEK transcription was previously shown to be induced by the high-risk human pa...
- Development of a Rab9 Transgenic Mouse and Its Ability to Increase the Lifespan of a Murine Model of Niemann-Pick Type C Disease
[作者：Kaptzan, T; West, SA; Holicky, EL; Wheatley, CL; Marks, DL; Wang, T; Peake, KB; Vance, J; Walkley, SU; Pagano, RE,期刊：American Journal of Pathology, 页码：14-20 , 文章类型： Article，,卷期：2009年174-1]
- Niemann-Pick, type C (NP-C) disease is an autosomal recessive neurovisceral. storage disorder in which cholesterol and sphingolipids accumulate. There is no specific treatment for this disease, which is characterized by ...
- CD83(+)CCR7(-) Dendritic Cells Accumulate in the Subepithelial Dome and Internalize Translocated Escherichia coli HB101 in the Peyer's Patches of Heal Crohn's Disease
[作者：Salim, SY; Silva, MA; Keita, AV; Larsson, M; Andersson, P; Magnusson, KE; Perdue, MH; Soderholm, JD,期刊：American Journal of Pathology, 页码：82-90 , 文章类型： Article，,卷期：2009年174-1]
- Recurrent Crohn's disease originates with small erosions in the follicle-associated epithelium overlying the Peyer's patches. Animal studies have illustrated mucosal immune regulation by dendritic cells located in the su...
- Latent Transforming Growth Factor-beta-Binding Protein-4 Regulates Transforming Growth Factor-beta 1 Bioavailability for Activation by Fibrogenic Lung Fibroblasts in Response to Bleomycin
[作者：Zhou, Y; Koli, K; Hagood, JS; Miao, M; Mavalli, M; Rifkin, DB; Murphy-Ullrich, JE,期刊：American Journal of Pathology, 页码：21-33 , 文章类型： Article，,卷期：2009年174-1]
- Recent evidence suggests that subsets of lung fibroblasts differentially contribute to fibrogenic progression. We have previously shown that a subset of rat lung fibroblasts with fibrogenic characteristics [Thy-1 (-) fib...
- Inhibition of AP-1 Transcriptional Activity Blocks the Migration, Invasion, and Experimental Metastasis of Murine Osteosarcoma
[作者：Leaner, VD; Chick, JF; Donninger, H; Linniola, I; Mendoza, A; Khanna, C; Birrer, MJ,期刊：American Journal of Pathology, 页码：265-275 , 文章类型： Article，,卷期：2009年174-1]
- A well-characterized murine osteosarcoma model for metastasis and invasion was used in this study to determine the role of AP-1 in the progression of this disease. We analyzed K12 and K7M2 cells, two clonally related mur...
- Irs2 Inactivation Suppresses Tumor Progression in Pten(+/-) Mice
[作者：Szabolcs, M; Keniry, M; Simpson, L; Reid, LJ; Koujak, S; Schiff, SC; Davidian, G; Licata, S; Gruvberger-Saal, S; Murty, VVVS; Nandula, S; Efstratiadis, A; Kushner, JA; White, MF; Parsons, R,期刊：American Journal of Pathology, 页码：276-286 , 文章类型： Article，,卷期：2009年174-1]
- Mutations in the phosphatase and tensin homologue (PTEN)/phosphatidylinositol-3 kinase-alpha (PI3K) signaling pathway are frequently found in human cancer. In addition, Pten(+/-) mice develop tumors in multiple organs be...
- CK2 beta Is Expressed in Endometrial Carcinoma and Has a Role in Apoptosis Resistance and Cell Proliferation
[作者：Pallares, J; Llobet, D; Santacana, M; Eritja, N; Velasco, A; Cuevas, D; Lopez, S; Palomar-Asenjo, V; Yeramian, A; Dolcet, X; Matias-Guiu, X,期刊：American Journal of Pathology, 页码：287-296 , 文章类型： Article，,卷期：2009年174-1]
- Protein kinase CK2 (CK2) is a serine/threonine kinase that participates in important cellular processes. We have recently demonstrated that CK2 plays a role in resistance to TRAIL/Fas-induced apoptosis in endometrial car...
- Type XVII Collagen is a Key Player in Tooth Enamel Formation
[作者：Asaka, T; Akiyama, M; Domon, T; Nishie, W; Natsuga, K; Fujita, Y; Abe, R; Kitagawa, Y; Shimizu, H,期刊：American Journal of Pathology, 页码：91-100 , 文章类型： Article，,卷期：2009年174-1]
- Inherited tooth enamel hypoplasia occurs due to mutations in genes that encode major enamel components. Enamel hypoplasia also has been reported in junctional epidermolysis bullosa, caused by mutations in the genes that ...
- Collagen Fragmentation Promotes Oxidative Stress and Elevates Matrix Metalloproteinase-1 in Fibroblasts in Aged Human Skin
[作者：Fisher, GJ; Quan, T; Purohit, T; Shao, Y; Cho, MK; He, T; Varani, J; Kang, S; Voorhees, JJ,期刊：American Journal of Pathology, 页码：101-114 , 文章类型： Article，,卷期：2009年174-1]
- Aged human skin is fragile because of fragmentation and loss of type I collagen fibrils, which confer strength and resiliency. We report here that dermal fibroblasts express increased levels of collagen-degrading matrix ...
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