- Synthesis and study of antiproliferative activity of novel thienopyrimidines on glioblastoma cells
[作者:Pedeboscq, S; Gravier, D; Casadebaig, F; Hou, G; Gissot, A; De Giorgi, F; Ichas, F; Cambard, J; Pometan, JP,期刊:European Journal of Medicinal Chemistry, 页码:2473-2479 , 文章类型: Article,,卷期:2010年45-6]
- The receptor tyrosine kinases (for example EGFR, PDGFR, VEGFR) are a transmembrane protein family which plays a crucial role in tumor growth, survival, metastasis dissemination and angiogenesis. During the past 10 years,...
- Synthesis and modulation properties of imidazo[4,5-b]pyridin-7-one and indazole-4,7-dione derivatives towards the Cryptosporidium parvum CpABC3 transporter
[作者:Zeinyeh, W; Xia, HX; Lawton, P; Radix, S; Marminon, C; Nebois, P; Walchshofer, N,期刊:European Journal of Medicinal Chemistry, 页码:2480-2488 , 文章类型: Article,,卷期:2010年45-6]
- The syntheses of new N-polysubstituted imidazo[4,5-b]pyridine-7-one (IF, 5 and 8a-8f) and indazole-4,7-dione (ID, 9 and 10) derivatives are described. The binding affinity of IP and ID towards the recombinant Nucleotide ...
- Synthesis and pharmacological characterization of a novel nitric oxide-releasing diclofenac derivative containing a benzofuroxan moiety
[作者:de Carvalho, PS; Marostica, M; Gambero, A; Pedrazzoli, J,期刊:European Journal of Medicinal Chemistry, 页码:2489-2493 , 文章类型: Article,,卷期:2010年45-6]
- 1-Oxy-benzo[1,2,5]oxadiazol-5-ylmethyl [2-(2,6-dichloro-phenylamino)-phenyl]-acetate, a new diclofenac derivative bearing a benzofuroxan heterocyclic moiety in its structure, was prepared by the reaction of sodium diclof...
- Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives
[作者:Alam, O; Mullick, P; Verma, SP; Gilani, SJ; Khan, SA; Siddiqui, N; Ahsan, W,期刊:European Journal of Medicinal Chemistry, 页码:2467-2472 , 文章类型: Article,,卷期:2010年45-6]
- A number of N-(4,6-substituted diphenylpyrimidin-2-yl) semicarbazones (4a-t) were synthesized and tested for their anticonvulsant activity against the two seizure models, maximal electroshock seizure (MES) and subcutaneo...
- Design, synthesis and 3D-QSAR of beta-carboline derivatives as potent antitumor agents
[作者:Cao, RH; Guan, XD; Shi, BX; Chen, ZY; Ren, ZH; Peng, WL; Song, HC,期刊:European Journal of Medicinal Chemistry, 页码:2503-2515 , 文章类型: Article,,卷期:2010年45-6]
- In a continuing effort to develop novel beta-carbolines endowed with better pharmacological profiles, a series of beta-carboline derivatives were designed and synthesized based on the previously developed SARs. Cytotoxic...
- Synthesis and antitumor evaluation of novel cyclic arylsulfonylureas: ADME-T and pharmacophore prediction
[作者:El-Deeb, IM; Bayoumi, SM; El-Sherbeny, MA; Abdel-Aziz, AAM,期刊:European Journal of Medicinal Chemistry, 页码:2516-2530 , 文章类型: Article,,卷期:2010年45-6]
- Novel derivatives of 5-(substituted)benzylidene-3-(4-substituted)phenylsulfonylimidazolidine-2,4-diones (3a-r), 1-(4-substituted)phenylsulfonyl-3-(4-substituted)phenylpyrimidine-2,4,6-(1H,3H,5H)-triones (6a-l), and 3-(4-...
- Synthesis and evaluation of novel chromone analogs for their inhibitory activity against interleukin-5
[作者:Thanigaimalai, P; Hoang, TAL; Lee, KC; Sharma, VK; Bang, SC; Yun, JH; Roh, E; Kim, Y; Jung, SH,期刊:European Journal of Medicinal Chemistry, 页码:2531-2536 , 文章类型: Article,,卷期:2010年45-6]
- A novel series of chromone analogs were synthesized and evaluated for their inhibitory activity against interleukin-5. Among them compounds 5-Cyclohexylmethoxy-3-(4-hydroxybenzyl)-4H-chromen-4-one (6a, 98% inhibition at ...
- Cytotoxic N-(fluorenyl-9-methoxycarbonyl) (Fmoc)-dipeptides: Structure-activity relationships and synergistic studies
[作者:Yen, CT; Wu, CC; Lee, JC; Chen, SL; Morris-Natschke, SL; Hsieh, PW; Wu, YC,期刊:European Journal of Medicinal Chemistry, 页码:2494-2502 , 文章类型: Article,,卷期:2010年45-6]
- The synthesis and cytotoxic evaluation of a series of Fmoc-based dipeptides are described. Among the thirty compounds, 4a, 8a, 12a, 2b, 4b, 10b, 3c, 4c and 6c showed potent activity against HepG2, Hep3B, MCF-7, MDA-MB-23...
- Synthesis and biological evaluation of dialkylaminoalkylamino benzo[c][1,7] and [1,8]phenanthrolines as antiproliferative agents
[作者:Serbetci, T; Genes, C; Depauw, S; Prado, S; Poree, FH; Hildebrand, MP; David-Cordonnier, MH; Michel, S; Tillequin, F,期刊:European Journal of Medicinal Chemistry, 页码:2547-2558 , 文章类型: Article,,卷期:2010年45-6]
- Benzo[c][1,7] and [1,8]phenanthroline substituted by dialkylaminoalkyl side chains at position C2 and C1, respectively, were synthesized and their biological activity evaluated. These compounds displayed more potent cyto...
- Synthesis of methyl-substituted xanthotoxol to clarify prooxidant effect of methyl on radical-induced oxidation of DNA
[作者:Xiao, C; Song, ZG; Liu, ZQ,期刊:European Journal of Medicinal Chemistry, 页码:2559-2566 , 文章类型: Article,,卷期:2010年45-6]
- 4-Methyl-8-hydroxylpsoralen (MXan) and 4,9-dimethy1-8-hydroxylpsoralen (DMXan) were synthesized in order to clarify the effect of methyl on the antioxidant effectiveness of xanthotoxol (8-hydroxyl-psoralen, Xan), which w...
- Synthesis and antiproliferative activity of oxazinocarbazole and N,N-bis(carbazolylmethyl)amine derivatives
[作者:Issa, S; Walchshofer, N; Kassab, I; Termoss, H; Chamat, S; Geahchan, A; Bouaziz, Z,期刊:European Journal of Medicinal Chemistry, 页码:2567-2577 , 文章类型: Article,,卷期:2010年45-6]
- The synthesis, structure elucidation and antitumoral activity of novel heterocyclic compounds containing a carbazole nucleus are reported. Oxazinocarbazoles were synthesized by application of the Mannich reaction to the ...
- Synthesis, biological evaluation and molecular docking of novel series of spiro [(2H,3H) quinazoline-2,1 '- cyclohexan]-4(1H)- one derivatives as anti-inflammatory and analgesic agents
[作者:Amin, KM; Kamel, MM; Anwar, MM; Khedr, M; Syam, YM,期刊:European Journal of Medicinal Chemistry, 页码:2117-2131 , 文章类型: Article,,卷期:2010年45-6]
- Three series of Spiro 1(2H,3H) quinazoline-2,1'-cyclohexan1-4(1H)-one derivatives have been synthesized. Some of the novel quinazolinone derivatives IIe, VIIIc, XIc, XIIb, XIIc, XVIb showed considerable potent anti-infla...
- 3D QSAR pharmacophore based virtual screening and molecular docking for identification of potential HSP90 inhibitors
[作者:Sakkiah, S; Thangapandian, S; John, S; Kwon, YJ; Lee, KW,期刊:European Journal of Medicinal Chemistry, 页码:2132-2140 , 文章类型: Article,,卷期:2010年45-6]
- Chemical features based 3D pharmacophore models were developed for HSP90 based on the known inhibitors using Discovery Studio V2.1. An optimal pharmacophore model was brought forth and validated using a decoy set, extern...
- Design, synthesis and evaluation of mutual prodrug of 4-biphenylacetic acid and quercetin tetramethyl ether (BPA-QTME) as gastrosparing NSAID
[作者:Madhukar, M; Sawraj, S; Sharma, PD,期刊:European Journal of Medicinal Chemistry, 页码:2591-2596 , 文章类型: Article,,卷期:2010年45-6]
- A novel mutual prodrug consisting of 4-biphenylacetic acid (BPA) and quercetin tetramethyl ether (QTME) has been synthesized as a gastrospanng NSAID, devoid of ulcerogenic side effects. The physicochemical properties, in...
|