- A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of beta-Secretase
[作者:KALLER MATTHEW R; HARRIED SCOTT S; ALBRECHT BRIAN; AMARANTE PATRICIA; BABUKHAN SAFURA; BARTBERGER MICHAEL D; BROWN JAMES; BROWN RYAN; CHEN KUI; CHENG YUAN; CITRON MARTIN; CROGHAN MICHAEL D; GRACEFFA RUSSELL; HICKMAN DEAN; JUDD TED; KRIEMEN CHUCK; LA DANIEL; LI VIVIAN; LOPEZ PATRICIA; LUO YI; MASSE CRAIG; MONENSCHEIN HOLGER; NGUYEN THOMAS; PENNINGTON LEWIS D; MIGUEL TISHA SAN; SICKMIER E ALLEN; WAHL ROBERT C; WEISS MATTHEW M; WEN PAUL H; WILLIAMSON TONI; WOOD STEPHEN; XUE MAY; YANG BRYANT; ZHANG JIANHUA; PATEL VINOD; ZHONG WENGE; HITCHCOCK STEPHEN,期刊:ACS Medicinal Chemistry Letters, 页码:886-891 , 文章类型: Article,,卷期:2012年3-11]
- beta-Secretase inhibitors are potentially disease-modifying treatments for Alzheimer's disease. Previous efforts in our laboratory have resulted in hydroxyethylamine-derived inhibitors such as 1 with low nanomolar potenc...
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