- Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells
[作者:Scholl, C; Frohling, S; Dunn, IF; Schinzel, AC; Barbie, DA; Kim, SY; Silver, SJ; Tamayo, P; Wadlow, RC; Ramaswamy, S; Dohner, K; Bullinger, L; Sandy, P; Boehm, JS; Root, DE; Jacks, T; Hahn, WC; Gilliland, DG,期刊:Cell, 页码:821-834 , 文章类型: Article,,卷期:2009年137-5]
- An alternative to therapeutic targeting of oncogenes is to perform "synthetic lethality'' screens for genes that are essential only in the context of specific cancer-causing mutations. We used high-throughput RNA interfe...
- A Genome-wide RNAi Screen Identifies Multiple Synthetic Lethal Interactions with the Ras Oncogene
[作者:Luo, J; Emanuele, MJ; Li, DN; Creighton, CJ; Schlabach, MR; Westbrook, TF; Wong, KK; Elledge, SJ,期刊:Cell, 页码:835-848 , 文章类型: Article,,卷期:2009年137-5]
- Oncogenic mutations in the small GTPase Ras are highly prevalent in cancer, but an understanding of the vulnerabilities of these cancers is lacking. We undertook a genome-wide RNAi screen to identify synthetic lethal int...
- Mechanistic Basis of 5 '-3 ' Translocation in SF1B Helicases
[作者:Saikrishnan, K; Powell, B; Cook, NJ; Webb, MR; Wigley, DB,期刊:Cell, 页码:849-859 , 文章类型: Article,,卷期:2009年137-5]
- Superfamily 1B (SF1B) helicases translocate in a 5'-3' direction and are required for a range of cellular activities across all domains of life. However, structural analyses to date have focused on how SF1A helicases ach...
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