- Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol
[作者:Kwon, HJ; Abi-Mosleh, L; Wang, ML; Deisenhofer, J; Goldstein, JL; Brown, MS; Infante, RE,期刊:Cell, 页码:1213-1224 , 文章类型: Article,,卷期:2009年137-7]
- LDL delivers cholesterol to lysosomes by receptor-mediated endocytosis. Exit of cholesterol from lysosomes requires two proteins, membrane-bound Niemann-Pick C1 (NPC1) and soluble NPC2. NPC2 binds cholesterol with its is...
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