- In situ quantitative monitoring of polyplexes and polyplex micelles in the blood circulation using intravital real-time confocal laser scanning microscopy
[作者:Nomoto, T; Matsumoto, Y; Miyata, K; Oba, M; Fukushima, S; Nishiyama, N; Yamasoba, T; Kataoka, K,期刊:Journal of controlled release, 页码:104-109 , 文章类型: Article,,卷期:2011年151-2]
- Surface modification using poly(ethylene glycol) (PEG) is a widely used strategy to improve the biocompatibility of cationic polymer-based nonviral gene vectors (polyplexes). A novel method based on intravital real-time ...
- Gastrointestinal contents in fasted state and post-lipid ingestion: In vivo measurements and in vitro models for studying oral drug delivery
[作者:Di Maio, S; Carrier, RL,期刊:Journal of controlled release, 页码:110-122 , 文章类型: Review,,卷期:2011年151-2]
- Lipids, either derived from food or used as drug delivery agents, can have a significant effect on orally delivered drug dissolution, absorption, and bioavailability. Despite numerous studies about fat-rich food/drug int...
- Reduction-triggered delivery using nucleoside-lipid based carriers possessing a cleavable PEG coating
[作者:Oumzil, K; Khiati, S; Grinstaff, MW; Barthelemy, P,期刊:Journal of controlled release, 页码:123-130 , 文章类型: Article,,卷期:2011年151-2]
- A new non-ionic nucleoside based lipid (DOU-SS-PEG(2000), 5'-PEG(2000)-2',3'-dioleoyluridine) featuring uridine (U) as nucleoside and 2',3'-dioleyl (DO), as lipid moieties and a poly(ethylene glycol) (PEG) thiolytic clea...
- Odorranalectin-conjugated nanoparticles: Preparation, brain delivery and pharmacodynamic study on Parkinson's disease following intranasal administration
[作者:Wen, ZY; Yan, ZQ; Hu, KL; Pang, ZQ; Cheng, XF; Guo, LR; Zhang, QZ; Jiang, XG; Fang, L; Lai, R,期刊:Journal of controlled release, 页码:131-138 , 文章类型: Article,,卷期:2011年151-2]
- Odorranalectin (OL) was recently identified as the smallest lectin with much less immunogenicity than other members of the lectin family. In this study, to improve nose-to-brain drug delivery and reduce the immunogenicit...
- Cell derived liposomes expressing CCR5 as a new targeted drug-delivery system for HIV infected cells
[作者:Bronshtein, T; Toledano, N; Danino, D; Pollack, S; Machluf, M,期刊:Journal of controlled release, 页码:139-148 , 文章类型: Article,,卷期:2011年151-2]
- Anti-retroviral-therapies against HIV/AIDS focus on inhibiting viral growth and may slow AIDS progression, but not cure the disease. Here we describe an approach to treat HIV as a cellular pathology by targeting cell der...
- Anti-PEG IgM production by siRNA encapsulated in a PEGylated lipid nanocarrier is dependent on the sequence of the siRNA
[作者:Tagami, T; Uehara, Y; Moriyoshi, N; Ishida, T; Kiwada, H,期刊:Journal of controlled release, 页码:149-154 , 文章类型: Article,,卷期:2011年151-2]
- We recently reported that the prolonged circulation property of PEGylated cationic liposomes containing nucleic acids disappears, if the second dose is injected within a few days later, due to the production of anti-PEG ...
- Dectin-1 targeting delivery of TNF-alpha antisense ODNs complexed with beta-1,3-glucan protects mice from LPS-induced hepatitis
[作者:Mochizuki, S; Sakurai, K,期刊:Journal of controlled release, 页码:155-161 , 文章类型: Article,,卷期:2011年151-2]
- Antisense therapy, the first concept of oligonucleotide therapeutics, was proposed more than two decades ago. However, the lack of suitable delivering carriers continues to be a major obstacle to practical therapy. In th...
- Mucoadhesive curcumin nanospheres: Biological activity, adhesion to stomach mucosa and release of curcumin into the circulation
[作者:Suwannateep, N; Banlunara, W; Wanichwecharungruang, SP; Chiablaem, K; Lirdprapamongkol, K; Svasti, J,期刊:Journal of controlled release, 页码:176-182 , 文章类型: Article,,卷期:2011年151-2]
- Although mucoadhesive drug carriers for the gastro-intestinal tract (GIT) have been reported, the mucoadhesive property and drug release characteristics have never been evaluated separately, whilst the adherence of the c...
- Nanobody - Shell functionalized thermosensitive core-crosslinked polymeric micelles for active drug targeting
[作者:Talelli, M; Rijcken, CJF; Oliveira, S; van der Meel, R; Henegouwen, PMPVE; Lammers, T; van Nostrum, CF; Storm, G; Hennink, WE,期刊:Journal of controlled release, 页码:183-192 , 文章类型: Article,,卷期:2011年151-2]
- The aim of this study was to develop poly(ethylene glycol)-b-poly[N-(2-hydroxypropyl) methacrylamide-lactate] (mPEG-b-p(HPMAm-Lac(n))) core-crosslinked thermosensitive biodegradable polymeric micelles suitable for active...
- Metallochelating liposomes with associated lipophilised norAbuMDP as biocompatible platform for construction of vaccines with recombinant His-tagged antigens: Preparation, structural study and immune response towards rHsp90
[作者:Masek, J; Bartheldyova, E; Turanek-Knotigova, P; Skrabalova, M; Korvasova, Z; Plockova, J; Koudelka, S; Skodova, P; Kulich, P; Krupka, M; Zachova, K; Czernekova, L; Horynova, M; Kratochvilova, I; Miller, AD; Zyka, D; Michalek, J; Vrbkova, J; Sebela, M; Ledvina, M; Raska, M; Turanek, J,期刊:Journal of controlled release, 页码:193-201 , 文章类型: Article,,卷期:2011年151-2]
- Hsp90-CA is present in cell wall of Candida pseudohyphae or hyphae - typical pathogenic morphotype for both systemic and mucosa! Candida infections. Heat shock protein from Candida albicans (hsp90-CA) is an important tar...
- A nanovector with complete discrimination for targeted delivery to Plasmodium falciparum-infected versus non-infected red blood cells in vitro
[作者:Urban, P; Estelrich, J; Cortes, A; Fernandez-Busquets, X,期刊:Journal of controlled release, 页码:202-211 , 文章类型: Article,,卷期:2011年151-2]
- Current administration methods of antimalarial drugs deliver the free compound in the blood stream, where it can be unspecifically taken up by all cells, and not only by Plasmodium-infected red blood cells (pRBCs). Nanos...
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