- Nanoscopic micelle delivery improves the photophysical properties and efficacy of photodynamic therapy of protoporphyrin IX
[作者:Ding, HY; Sumer, BD; Kessinger, CW; Dong, Y; Huang, G; Boothman, DA; Gao, JM,期刊:Journal of controlled release, 页码:271-277 , 文章类型: Article,,卷期:2011年151-3]
- Nanodelivery systems have shown considerable promise in increasing the solubility and delivery efficiency of hydrophobic photosensitizers for photodynamic therapy (PDT) applications. In this study, we report the preparat...
- Microencapsulation of inorganic nanocrystals into PLGA microsphere vaccines enables their intracellular localization in dendritic cells by electron and fluorescence microscopy
[作者:Schliehe, C; Schliehe, C; Thiry, M; Tromsdorf, UI; Hentschel, J; Weller, H; Groettrup, M,期刊:Journal of controlled release, 页码:278-285 , 文章类型: Article,,卷期:2011年151-3]
- Biodegradable poly-(D,L-lactide-co-glycolide) microspheres (PLGA-MS) are approved as a drug delivery system in humans and represent a promising antigen delivery device for immunotherapy against cancer. Immune responses f...
- Development and characterization of Cyclosporine A loaded nanoparticles for ocular drug delivery: Cellular toxicity, uptake, and kinetic studies
[作者:Aksungur, P; Demirbilek, M; Denkbas, EB; Vandervoort, J; Ludwig, A; Unlu, N,期刊:Journal of controlled release, 页码:286-294 , 文章类型: Article,,卷期:2011年151-3]
- Dry eye syndrome is a common disorder of the tear film caused by decreased tear production or increased evaporation. The objective of this study was to evaluate the potential effectiveness of Cyclosporine A (CsA) nanopar...
- Development of efficient acid cleavable multifunctional prodrugs derived from dendritic polyglycerol with a poly(ethylene glycol) shell
[作者:Calderon, M; Welker, P; Licha, K; Fichtner, I; Graeser, R; Haag, R; Kratz, F,期刊:Journal of controlled release, 页码:295-301 , 文章类型: Article,,卷期:2011年151-3]
- In an attempt to explore the potential of dendritic systems for the development of effective anticancer drug delivery systems, we explored a simple modular approach of preparing polyglycerol doxorubicin prodrugs, with fl...
- Use of a nanoporous biodegradable miniature device to regulate cytokine release for cancer treatment
[作者:He, HY; Grignol, V; Karpa, V; Yen, C; LaPerle, K; Zhang, XL; Jones, NB; Liang, MI; Lesinski, GB; Ho, WSW; Carson, WE; Lee, LJ,期刊:Journal of controlled release, 页码:239-245 , 文章类型: Article,,卷期:2011年151-3]
- The clinical management of locally recurrent or unresectable malignant melanoma continues to pose a significant challenge. These lesions are typically painful and currently available treatments, such as repeated intratum...
- Development of a lyophilized plasmid/LPEI polyplex formulation with long-term stability-A step closer from promising technology to application
[作者:Kasper, JC; Schaffert, D; Ogris, M; Wagner, E; Friess, W,期刊:Journal of controlled release, 页码:246-255 , 文章类型: Article,,卷期:2011年151-3]
- Cationic polymer/DNA complexes are limited by their instability in aqueous suspensions and usually have to be freshly prepared prior to administration. Thus, the development of isotonic lyophilized polyplex formulations ...
- Electro-gene transfer to skin using a noninvasive multielectrode array
[作者:Guo, SQ; Donate, A; Basu, G; Lundberg, C; Heller, L; Heller, R,期刊:Journal of controlled release, 页码:256-262 , 文章类型: Article,,卷期:2011年151-3]
- Because of its large surface area and easy access for both delivery and monitoring, the skin is an attractive target for gene therapy for cutaneous diseases, vaccinations and several metabolic disorders. The critical fac...
- Anticancer and antiangiogenic activity of HPMA copolymer-aminohexylgeldanamycin-RGDfK conjugates for prostate cancer therapy
[作者:Greish, K; Ray, A; Bauer, H; Larson, N; Malugin, A; Pike, D; Haider, M; Ghandehari, H,期刊:Journal of controlled release, 页码:263-270 , 文章类型: Article,,卷期:2011年151-3]
- Tumor progression is dependent on neoangiogenesis for blood supply. Neovasculature over-express alpha(v)beta(3) integrins which recognize the Arg-Gly-Asp (RGD) sequence in the extracellular matrix. N-(2-hydroxypropyl)met...
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