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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共31条记录   Building on the foundation of daring hypotheses: Using the MKK4 metastasis suppressor to develop models of dormancy and metastatic colonization [作者：Knopeke, MT; Ritschdorff, ET; Clark, R; Vander Griend, DJ; Khan, S; Thobe, M; Shear, JB; Rinker-Schaeffer, CW,期刊：FEBS Letters, 页码：3159-3165 , 文章类型： Review，,卷期：2011年585-20] The identification of a novel metastasis suppressor function for the MAP Kinase Kinase 4 protein established a role for the stress-activated kinases in regulating the growth of disseminated cancer cells. In this review, ... Dissecting the diverse functions of the metastasis suppressor CD82/KAI1 [作者：Tsai, YC; Weissman, AM,期刊：FEBS Letters, 页码：3166-3173 , 文章类型： Review，,卷期：2011年585-20] The recent identification of metastasis suppressor genes, the products of which inhibit metastasis but not primary tumor growth, distinguishes oncogenic transformation and tumor suppression from a hallmark of malignancy,... Functional modulation of the metastatic suppressor Nm23-H1 by oncogenic viruses [作者：Saha, A; Robertson, ES,期刊：FEBS Letters, 页码：3174-3184 , 文章类型： Review，,卷期：2011年585-20] Evidence over the last two decades from a number of disciplines has solidified some fundamental concepts in metastasis, a major contributor to cancer associated deaths. However, significant advances have been made in con... Unraveling the enigmatic complexities of BRMS1-mediated metastasis suppression [作者：Hurst, DR; Welch, DR,期刊：FEBS Letters, 页码：3185-3190 , 文章类型： Review，,卷期：2011年585-20] Expression of BRMS1 causes dramatic suppression of metastasis in multiple in vivo model systems. As we gain further insight into the biochemical mechanisms of BRMS1, we appreciate the importance of both molecular and cel... Assembly and disassembly of the ESCRT-III membrane scission complex [作者：Adell, MAY; Teis, D,期刊：FEBS Letters, 页码：3191-3196 , 文章类型： Review，,卷期：2011年585-20] The ESCRT (endosomal sorting complex required for transport) pathway promotes the final membrane scission step at the end of cytokinesis, assists viral budding and generates multivesicular bodies (MVBs). These seemingly ... The Nucleosome Remodeling Factor [作者：Alkhatib, SG; Landry, JW,期刊：FEBS Letters, 页码：3197-3207 , 文章类型： Review，,卷期：2011年585-20] An essential component of the chromatin remodeling machinery is NURF ( Nucleosome Remodeling Factor), the founding member of the ISWI family of chromatin remodeling complexes. In vertebrates and invertebrates alike, NURF... Protein kinase C-theta in platelet activation [作者：Cohen, S; Braiman, A; Shubinsky, G; Isakov, N,期刊：FEBS Letters, 页码：3208-3215 , 文章类型： Review，,卷期：2011年585-20] Members of the protein kinase C (PKC) family of serine/threonine kinases have been implicated in several physiological processes regulating the activation response of platelets. They are involved in processes leading to ... Are there errors in glycogen biosynthesis and is laforin a repair enzyme? [作者：Roach, PJ,期刊：FEBS Letters, 页码：3216-3218 , 文章类型： Article，,卷期：2011年585-20] Glycogen, a branched polymer of glucose, is well known as a cellular reserve of metabolic energy and/or biosynthetic precursors. Besides glucose, however, glycogen contains small amounts of covalent phosphate, present as... The beta-isoform of neuronal nitric oxide synthase (nNOS) lacking the PDZ domain is localized at the sarcolemma [作者：Baum, O; Schlappi, S; Huber-Abel, FA; Weichert, A; Hoppeler, H; Zakrzewicz, A,期刊：FEBS Letters, 页码：3219-3223 , 文章类型： Article，,卷期：2011年585-20] In skeletal muscles, the expression of neuronal NO synthase (nNOS) isoforms is uncharacterized at the protein level. We therefore conducted epitope mapping with anti-peptide-antibodies. Antibodies specific for the nNOS N... Glucocorticoid suppresses BDNF-stimulated MAPK/ERK pathway via inhibiting interaction of Shp2 with TrkB [作者：Kumamaru, E; Numakawa, T; Adachi, N; Kunugi, H,期刊：FEBS Letters, 页码：3224-3228 , 文章类型： Article，,卷期：2011年585-20] Increased glucocorticoids (GCs) have been implicated in the pathophysiology of depressive disorder. We previously found that dexamethasone (DEX, a synthetic GC) repressed brain-derived neurotrophic factor (BDNF)-induced ... Phosphorylation of LRP1 regulates the interaction with Fe65 [作者：Klug, W; Dietl, A; Simon, B; Sinning, I; Wild, K,期刊：FEBS Letters, 页码：3229-3235 , 文章类型： Article，,卷期：2011年585-20] Neuronal Fe65 is a central adapter for the intracellular protein network of Alzheimer's disease related amyloid precursor protein (APP). It contains a unique tandem array of phosphotyrosine-binding (PTB) domains that rec... c-Fos regulates hepatitis C virus propagation [作者：Kang, SM; Lim, S; Won, SJ; Shin, YJ; Lim, YS; Ahn, BY; Hwang, SB,期刊：FEBS Letters, 页码：3236-3244 , 文章类型： Article，,卷期：2011年585-20] Hepatitis C virus (HCV) RNA replication requires cellular factors as well as viral non-structural proteins (NS protein). Using small interfering RNA (siRNA) library screening, we previously identified c-Fos as a host fac... X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket [作者：Lountos, GT; Jobson, AG; Tropea, JE; Self, CR; Zhang, GT; Pommier, Y; Shoemaker, RH; Waugh, DS,期刊：FEBS Letters, 页码：3245-3249 , 文章类型： Article，,卷期：2011年585-20] The serine/threonine checkpoint kinase 2 (Chk2) is an attractive molecular target for the development of small molecule inhibitors to treat cancer. Here, we report the rational design of Chk2 inhibitors that target the g... Hell's Gate globin I: An acid and thermostable bacterial hemoglobin resembling mammalian neuroglobin [作者：Teh, AH; Saito, JA; Baharuddin, A; Tuckerman, JR; Newhouse, JS; Kanbe, M; Newhouse, EI; Rahim, RA; Favier, F; Didierjean, C; Sousa, EHS; Stott, MB; Dunfield, PF; Gonzalez, G; Gilles-Gonzalez, MA; Najimudin, N; Alam, M,期刊：FEBS Letters, 页码：3250-3258 , 文章类型： Article，,卷期：2011年585-20] Hell's Gate globin I (HGbI), a heme-containing protein structurally homologous to mammalian neuroglobins, has been identified from an acidophilic and thermophilic obligate methanotroph, Methylacidiphilum infernorum. HGbI... Human cyclic nucleotide phosphodiesterases possess a much broader substrate-specificity than previously appreciated [作者：Reinecke, D; Burhenne, H; Sandner, P; Kaever, V; Seifert, R,期刊：FEBS Letters, 页码：3259-3262 , 文章类型： Article，,卷期：2011年585-20] Phosphodiesterases (PDEs) capable of degrading cAMP and cGMP are indispensable for the regulation of cyclic nucleotide-mediated signals. The existence of other cyclic nucleotides such as cCMP and cUMP has been discussed ... miRNA-1 targets fibronectin1 and suppresses the migration and invasion of the HEp2 laryngeal squamous carcinoma cell line [作者：Wang, FF; Song, G; Liu, M; Li, X; Tang, H,期刊：FEBS Letters, 页码：3263-3269 , 文章类型： Article，,卷期：2011年585-20] MicroRNAs (miRNAs) are an evolutionarily conserved class of endogenous, non-coding RNAs that modulate gene expression at the post-transcriptional level and are involved in tumorigenesis. In this study, we demonstrate tha...