- Building on the foundation of daring hypotheses: Using the MKK4 metastasis suppressor to develop models of dormancy and metastatic colonization
[作者:Knopeke, MT; Ritschdorff, ET; Clark, R; Vander Griend, DJ; Khan, S; Thobe, M; Shear, JB; Rinker-Schaeffer, CW,期刊:FEBS Letters, 页码:3159-3165 , 文章类型: Review,,卷期:2011年585-20]
- The identification of a novel metastasis suppressor function for the MAP Kinase Kinase 4 protein established a role for the stress-activated kinases in regulating the growth of disseminated cancer cells. In this review, ...
- The Nucleosome Remodeling Factor
[作者:Alkhatib, SG; Landry, JW,期刊:FEBS Letters, 页码:3197-3207 , 文章类型: Review,,卷期:2011年585-20]
- An essential component of the chromatin remodeling machinery is NURF ( Nucleosome Remodeling Factor), the founding member of the ISWI family of chromatin remodeling complexes. In vertebrates and invertebrates alike, NURF...
- Protein kinase C-theta in platelet activation
[作者:Cohen, S; Braiman, A; Shubinsky, G; Isakov, N,期刊:FEBS Letters, 页码:3208-3215 , 文章类型: Review,,卷期:2011年585-20]
- Members of the protein kinase C (PKC) family of serine/threonine kinases have been implicated in several physiological processes regulating the activation response of platelets. They are involved in processes leading to ...
- Are there errors in glycogen biosynthesis and is laforin a repair enzyme?
[作者:Roach, PJ,期刊:FEBS Letters, 页码:3216-3218 , 文章类型: Article,,卷期:2011年585-20]
- Glycogen, a branched polymer of glucose, is well known as a cellular reserve of metabolic energy and/or biosynthetic precursors. Besides glucose, however, glycogen contains small amounts of covalent phosphate, present as...
- The beta-isoform of neuronal nitric oxide synthase (nNOS) lacking the PDZ domain is localized at the sarcolemma
[作者:Baum, O; Schlappi, S; Huber-Abel, FA; Weichert, A; Hoppeler, H; Zakrzewicz, A,期刊:FEBS Letters, 页码:3219-3223 , 文章类型: Article,,卷期:2011年585-20]
- In skeletal muscles, the expression of neuronal NO synthase (nNOS) isoforms is uncharacterized at the protein level. We therefore conducted epitope mapping with anti-peptide-antibodies. Antibodies specific for the nNOS N...
- c-Fos regulates hepatitis C virus propagation
[作者:Kang, SM; Lim, S; Won, SJ; Shin, YJ; Lim, YS; Ahn, BY; Hwang, SB,期刊:FEBS Letters, 页码:3236-3244 , 文章类型: Article,,卷期:2011年585-20]
- Hepatitis C virus (HCV) RNA replication requires cellular factors as well as viral non-structural proteins (NS protein). Using small interfering RNA (siRNA) library screening, we previously identified c-Fos as a host fac...
- X-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocket
[作者:Lountos, GT; Jobson, AG; Tropea, JE; Self, CR; Zhang, GT; Pommier, Y; Shoemaker, RH; Waugh, DS,期刊:FEBS Letters, 页码:3245-3249 , 文章类型: Article,,卷期:2011年585-20]
- The serine/threonine checkpoint kinase 2 (Chk2) is an attractive molecular target for the development of small molecule inhibitors to treat cancer. Here, we report the rational design of Chk2 inhibitors that target the g...
- Hell's Gate globin I: An acid and thermostable bacterial hemoglobin resembling mammalian neuroglobin
[作者:Teh, AH; Saito, JA; Baharuddin, A; Tuckerman, JR; Newhouse, JS; Kanbe, M; Newhouse, EI; Rahim, RA; Favier, F; Didierjean, C; Sousa, EHS; Stott, MB; Dunfield, PF; Gonzalez, G; Gilles-Gonzalez, MA; Najimudin, N; Alam, M,期刊:FEBS Letters, 页码:3250-3258 , 文章类型: Article,,卷期:2011年585-20]
- Hell's Gate globin I (HGbI), a heme-containing protein structurally homologous to mammalian neuroglobins, has been identified from an acidophilic and thermophilic obligate methanotroph, Methylacidiphilum infernorum. HGbI...
- miRNA-1 targets fibronectin1 and suppresses the migration and invasion of the HEp2 laryngeal squamous carcinoma cell line
[作者:Wang, FF; Song, G; Liu, M; Li, X; Tang, H,期刊:FEBS Letters, 页码:3263-3269 , 文章类型: Article,,卷期:2011年585-20]
- MicroRNAs (miRNAs) are an evolutionarily conserved class of endogenous, non-coding RNAs that modulate gene expression at the post-transcriptional level and are involved in tumorigenesis. In this study, we demonstrate tha...
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