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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共17条记录   BLT2 phosphorylation at Thr(355) by Akt is necessary for BLT2-mediated chemotaxis [作者：Wei, JD; Kim, JY; Kim, JH,期刊：FEBS Letters, 页码：3501-3506 , 文章类型： Article，,卷期：2011年585-22] BLT2, a low-affinity leukotriene B(4) (LTB(4)) receptor, is a member of the G protein-coupled receptor family and is involved in multiple cellular responses, including chemotaxis. Despite its biological significance, the... Mosquito Aedes aegypti (L.) leucokinin receptor is critical for in vivo fluid excretion post blood feeding [作者：Kersch, CN; Pietrantonio, PV,期刊：FEBS Letters, 页码：3507-3512 , 文章类型： Article，,卷期：2011年585-22] The evolution of the blood feeding adaptation in mosquitoes required hormonal coordination of multiple physiological processes (behavior, digestion, diuresis, oogenesis). The Aedes kinins (leucokinin-like neuropeptides) ... The mode of alpha-synuclein binding to membranes depends on lipid composition and lipid to protein ratio [作者：Shvadchak, VV; Yushchenko, DA; Pievo, R; Jovin, TM,期刊：FEBS Letters, 页码：3513-3519 , 文章类型： Article，,卷期：2011年585-22] Interactions of the presynaptic protein alpha-synuclein with membranes are involved in its physiological action as well as in the pathological misfolding and aggregation related to Parkinsons's disease. We studied the co... The activation cycle of Rab GTPase Ypt32 reveals structural determinants of effector recruitment and GDI binding [作者：Sultana, A; Jin, Y; Dregger, C; Franklin, E; Weisman, LS; Khan, AR,期刊：FEBS Letters, 页码：3520-3527 , 文章类型： Article，,卷期：2011年585-22] Rab GTPases localize to distinct sub-cellular compartments and regulate vesicle trafficking in eukaryotic cells. Yeast Rabs Ypt31/32 and Sec4 have 68% homology and bind to common interactors, yet play distinct roles in t... Identification of endogenous ligands bound to bacterially expressed human and E. coli dihydrofolate reductase by 2D NMR [作者：Bhabha, G; Tuttle, L; Martinez-Yamout, MA; Wright, PE,期刊：FEBS Letters, 页码：3528-3532 , 文章类型： Article，,卷期：2011年585-22] Dihydrofolate reductase (DHFR) is a well-studied drug target and a paradigm for understanding enzyme catalysis. Preparation of pure DHFR samples, in defined ligand-bound states, is a prerequisite for in vitro studies and... Catalytic activity of MsbA reconstituted in nanodisc particles is modulated by remote interactions with the bilayer [作者：Kawai, T; Caaveiro, JMM; Abe, R; Katagiri, T; Tsumoto, K,期刊：FEBS Letters, 页码：3533-3537 , 文章类型： Article，,卷期：2011年585-22] ATP-binding cassette (ABC) transporters couple hydrolysis of ATP with vectorial transport across the cell membrane. We have reconstituted ABC transporter MsbA in nanodiscs of various sizes and lipid compositions to test ... A prokaryotic acyl-CoA reductase performing reduction of fatty acyl-CoA to fatty alcohol [作者：Hofvander, P; Doan, TTP; Hamberg, M,期刊：FEBS Letters, 页码：3538-3543 , 文章类型： Article，,卷期：2011年585-22] The reduction of acyl-CoA or acyl-ACP to fatty alcohol occurs via a fatty aldehyde intermediate. In prokaryotes this reaction is thought to be performed by separate enzymes for each reduction step while in eukaryotes the... CD38: A NAADP degrading enzyme [作者：Schmid, F; Bruhn, S; Weber, K; Mittrucker, HW; Guse, AH,期刊：FEBS Letters, 页码：3544-3548 , 文章类型： Article，,卷期：2011年585-22] The role of the multifunctional enzyme CD38 in formation of the Ca(2+)-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated. Gene silencing of CD38 did neither inhibit NAADP ... The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response [作者：Bernhard, W; Barreto, K; Saunders, A; Dahabieh, MS; Johnson, P; Sadowski, I,期刊：FEBS Letters, 页码：3549-3554 , 文章类型： Article，,卷期：2011年585-22] Latent HIV-1 (human immunodeficiency virus-1) provirus is unaffected by current AIDS (acquired immunodeficiency syndrome) therapies. We show here that chaetocin, an SUV39H1 histone methyltransferase inhibitor, causes 25-... Mechanism of KATP hyperactivity and sulfonylurea tolerance due to a diabetogenic mutation in L0 helix of sulfonylurea receptor 1 (ABCC8) [作者：Babenko, AP; Vaxillaire, M,期刊：FEBS Letters, 页码：3555-3559 , 文章类型： Article，,卷期：2011年585-22] Activating mutations in different domains of the ABCC8 gene-coded sulfonylurea receptor 1 (SUR1) cause neonatal diabetes. Here we show that a diabetogenic mutation in an unexplored helix preceding the ABC core of SUR1 dr... MicroRNA 506 regulates expression of PPAR alpha in hydroxycamptothecin-resistant human colon cancer cells [作者：Tong, JL; Zhang, CP; Nie, F; Xu, XT; Zhu, MM; Xiao, SD; Ran, ZH,期刊：FEBS Letters, 页码：3560-3568 , 文章类型： Article，,卷期：2011年585-22] Chemotherapeutic drug resistance remains a major obstacle to the successful treatment of colon cancer. Here, we show that 77 differentially expressed miRNAs were identified in SW1116/HCPT versus SW1116, and over-expresse... Down-regulation of Aurora B kinase induces cellular senescence in human fibroblasts and endothelial cells through a p53-dependent pathway [作者：Kim, HJ; Cho, JH; Quan, H; Kim, JR,期刊：FEBS Letters, 页码：3569-3576 , 文章类型： Article，,卷期：2011年585-22] Aurora B kinase (Aurora-B) functions in chromosome segregation and cleavage of polar spindle microtubules. However, its role in cellular senescence remains elusive. Here, we investigated Aurora-B effects on cellular sene... I kappa BL, a novel member of the nuclear I kappa B family, inhibits inflammatory cytokine expression [作者：Chiba, T; Miyashita, K; Sugoh, T; Warita, T; Inoko, H; Kimura, M; Sato, T,期刊：FEBS Letters, 页码：3577-3581 , 文章类型： Article，,卷期：2011年585-22] We previously reported that I kappa BL prevents experimental autoimmune arthritis. The molecular mechanism, however, still remains unclear. In contrast to four splicing-isoforms of I kappa BL in human, two isoforms were ... Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR [作者：Huang, TC; Chang, HY; Chen, CY; Wu, PY; Lee, H; Liao, YF; Hsu, WM; Huang, HC; Juan, HF,期刊：FEBS Letters, 页码：3582-3586 , 文章类型： Article，,卷期：2011年585-22] Neuroblastoma is the most common extracranial solid tumor in children. We investigate whether miR-124, the abundant neuronal miRNA, plays a pivotal role in neuroblastoma. Knockdown of miR-124 promotes neuroblastoma SK-N-... The structure of active opsin as a basis for identification of GPCR agonists by dynamic homology modelling and virtual screening assays [作者：Schneider, M; Wolf, S; Schlitter, J; Gerwert, K,期刊：FEBS Letters, 页码：3587-3592 , 文章类型： Article，,卷期：2011年585-22] Most of the currently available G protein-coupled receptor (GPCR) crystal structures represent an inactive receptor state, which has been considered to be suitable only for the discovery of antagonists and inverse agonis... Crystal structure of the EphA4 protein tyrosine kinase domain in the apo- and dasatinib-bound state [作者：Farenc, C; Celie, PHN; Tensen, CP; de Esch, IJP; Siegal, G,期刊：FEBS Letters, 页码：3593-3599 , 文章类型： Article，,卷期：2011年585-22] The Eph family of receptor tyrosine kinases regulates diverse cellular processes while the overexpression of a member of this family, EphA4, has been reported in a variety of malignant carcinomas. To gain insight into mo...