- Reprogramming of pancreatic exocrine cells towards a beta (beta) cell character using Pdx1, Ngn3 and MafA
[作者:Akinci, E; Banga, A; Greder, LV; Dutton, JR; Slack, JMW,期刊:Biochemical Journal, 页码:539-550 , 文章类型: Article,,卷期:2012年442-3]
- Pdx1 (pancreatic and duodenal homeobox 1), Ngn3 (neurogenin 3) and MafA (v-maf musculoaponeurotic fibrosarcoma oncogene family, protein A) have been reported to bring about the transdifferentiation of pancreatic exocrine...
- A Golgi-localized MATE transporter mediates iron homoeostasis under osmotic stress in Arabidopsis
[作者:Seo, PJ; Park, J; Park, MJ; Kim, YS; Kim, SG; Jung, JH; Park, CM,期刊:Biochemical Journal, 页码:551-561 , 文章类型: Article,,卷期:2012年442-3]
- Iron is an essential micronutrient that acts as a cofactor in a wide variety of pivotal metabolic processes, such as the electron transport chain of respiration, photosynthesis and redox reactions, in plants. However, it...
- A molten globule-to-ordered structure transition of Drosophila melanogaster crammer is required for its ability to inhibit cathepsin
[作者:Tseng, TS; Cheng, CS; Chen, DJ; Shih, MF; Liu, YN; Hsu, STD; Lyu, PC,期刊:Biochemical Journal, 页码:563-572 , 文章类型: Article,,卷期:2012年442-3]
- Drosophila melanogaster crammer is a novel cathepsin inhibitor that is involved in LTM (long-term memory) formation. The mechanism by which the inhibitory activity is regulated remains unclear. In the present paper we ha...
- RCD1-DREB2A interaction in leaf senescence and stress responses in Arabidopsis thaliana
[作者:Vainonen, JP; Jaspers, P; Wrzaczek, M; Lamminmaki, A; Reddy, RA; Vaahtera, L; Brosche, M; Kangasjarvi, J,期刊:Biochemical Journal, 页码:573-581 , 文章类型: Article,,卷期:2012年442-3]
- Transcriptional regulation of gene expression is one major determinant of developmental control and stress adaptation in virtually all living organisms. In recent years numerous transcription factors controlling various ...
- Inhibition of protein translocation at the endoplasmic reticulum promotes activation of the unfolded protein response
[作者:McKibbin, C; Mares, A; Piacenti, M; Williams, H; Roboti, P; Puumalainen, M; Callan, AC; Lesiak-Mieczkowska, K; Linder, S; Harant, H; High, S; Flitsch, SL; Whitehead, RC; Swanton, E,期刊:Biochemical Journal, 页码:639-648 , 文章类型: Article,,卷期:2012年442-3]
- Selective small-molecule inhibitors represent powerful tools for the dissection of complex biological processes. ES1 (eeyarestatin 1) is a novel modulator of ER (endoplasmic reticulum) function. In the present study, we ...
- Protein kinase D2 has a restricted but critical role in T-cell antigen receptor signalling in mature T-cells
[作者:Navarro, MN; Sinclair, LV; Feijoo-Carnero, C; Clarke, R; Matthews, SA; Cantrell, DA,期刊:Biochemical Journal, 页码:649-659 , 文章类型: Article,,卷期:2012年442-3]
- PKD (protein kinase D) 2 is a serine/threonine kinase activated by diacylglycerol in response to engagement of antigen receptors in lymphocytes. To explore PKD2 regulation and function in TCR (T-cell antigen receptor) si...
- Selective reduction of hydroperoxyeicosatetraenoic acids to their hydroxy derivatives by apolipoprotein D: implications for lipid antioxidant activity and Alzheimer's disease
[作者:Bhatia, S; Knoch, B; Wong, J; Kim, WS; Else, PL; Oakley, AJ; Garner, B,期刊:Biochemical Journal, 页码:713-721 , 文章类型: Article,,卷期:2012年442-3]
- ApoD (apolipoprotein D) is up-regulated in AD (Alzheimer's disease) and upon oxidative stress. ApoD inhibits brain lipid peroxidation in vivo, but the mechanism is unknown. Specific methionine residues may inhibit lipid ...
- Cell signalling by reactive lipid species: new concepts and molecular mechanisms
[作者:Higdon, A; Diers, AR; Oh, JY; Landar, A; Darley-Usmar, VM,期刊:Biochemical Journal, 页码:453-464 , 文章类型: Review,,卷期:2012年442-3]
- The process of lipid peroxidation is widespread in biology and is mediated through both enzymatic and non-enzymatic pathways. A significant proportion of the oxidized lipid products are electrophilic in nature, the RLS (...
- Allosteric antibody inhibition of human hepsin protease
[作者:Koschubs, T; Dengl, S; Durr, H; Kaluza, K; Georges, G; Hartl, C; Jennewein, S; Lanzendorfer, M; Auer, J; Stern, A; Huang, KS; Packman, K; Gubler, U; Kostrewa, D; Ries, S; Hansen, S; Kohnert, U; Cramer, P; Mundigl, O,期刊:Biochemical Journal, 页码:483-494 , 文章类型: Article,,卷期:2012年442-3]
- Hepsin is a type II transmembrane senile protease that is expressed in several human tissues. Overexpression of hepsin has been found to correlate with tumour progression and metastasis, which is so far best studied for ...
- The chromatin-binding protein HMGN3 stimulates histone acetylation and transcription across the Glyt1 gene
[作者:Barkess, G; Postnikov, Y; Campos, CD; Mishra, S; Mohan, G; Verma, S; Bustin, M; West, KL,期刊:Biochemical Journal, 页码:495-505 , 文章类型: Article,,卷期:2012年442-3]
- HMGNs are nucleosome-binding proteins that alter the pattern of histone modifications and modulate the binding of linker histones to chromatin. The HMGN3 family member exists as two splice forms. HMGN3a which is full-len...
- Macromolecular and small-molecule modulation of intracellular A beta(42) aggregation and associated toxicity
[作者:Chakrabortee, S; Liu, Y; Zhang, L; Matthews, HR; Zhang, HR; Pan, N; Cheng, CR; Guan, SH; Guo, DA; Huang, ZB; Zheng, YZ; Tunnacliffe, A,期刊:Biochemical Journal, 页码:507-515 , 文章类型: Article,,卷期:2012年442-3]
- A beta (amyloid beta-peptide) has a central role in AD (Alzheimer's disease) where neuronal toxicity is linked to its extracellular and intracellular accumulation as oligomeric species. Searching for molecules that atten...
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