- Steroid Receptor Coactivator-interacting Protein (SIP) Inhibits Caspase-independent Apoptosis by Preventing Apoptosis-inducing Factor (AIF) from Being Released from Mitochondria
[作者:Wang, DD; Liang, J; Zhang, Y; Gui, B; Wang, F; Yi, X; Sun, LY; Yao, Z; Shang, YF,期刊:Journal of Biological Chemistry, 页码:12612-12621 , 文章类型: Article,,卷期:2012年287-16]
- Apoptosis-inducing factor (AIF) is a caspase-independent death effector. Normally residing in the mitochondrial intermembrane space, AIF is released and translocated to the nucleus in response to proapoptotic stimuli. Nu...
- Fibroblast Growth Factor-21 (FGF21) Regulates Low-density Lipoprotein Receptor (LDLR) Levels in Cells via the E3-ubiquitin Ligase Mylip/Idol and the Canopy2 (Cnpy2)/Mylip-interacting Saposin-like Protein (Msap)
[作者:Do, HT; Tselykh, TV; Makela, J; Ho, TH; Olkkonen, VM; Bornhauser, BC; Korhonen, L; Zelcer, N; Lindholm, D,期刊:Journal of Biological Chemistry, 页码:12602-12611 , 文章类型: Article,,卷期:2012年287-16]
- The LDLR is a critical factor in the regulation of blood cholesterol levels that are altered in different human diseases. The level of LDLR in the cell is regulated by both transcriptional and post-transcriptional events...
- Environment of Tyr(Z) in Photosystem II from Thermosynechococcus elongatus in which PsbA2 Is the D1 Protein
[作者:Sugiura, M; Ogami, S; Kusumi, M; Un, S; Rappaport, F; Boussac, A,期刊:Journal of Biological Chemistry, 页码:13336-13347 , 文章类型: Article,,卷期:2012年287-16]
- The main cofactors that determine the photosystem II (PSII) oxygen evolution activity are borne by the D1 and D2 subunits. In the cyanobacterium Thermosynechococcus elongatus, there are three psbA genes coding for D1. Am...
- Insights into Substrate Specificity and Metal Activation of Mammalian Tetrahedral Aspartyl Aminopeptidase
[作者:Chen, YY; Farquhar, ER; Chance, MR; Palczewski, K; Kiser, PD,期刊:Journal of Biological Chemistry, 页码:13356-13370 , 文章类型: Article,,卷期:2012年287-16]
- Aminopeptidases are key enzymes involved in the regulation of signaling peptide activity. Here, we present a detailed biochemical and structural analysis of an evolutionary highly conserved aspartyl aminopeptidase called...
- Identification of Mannose Receptor as Receptor for Hepatocyte Growth Factor beta-Chain NOVEL LIGAND-RECEPTOR PATHWAY FOR ENHANCING MACROPHAGE PHAGOCYTOSIS
[作者:Ohnishi, H; Oka, K; Mizuno, S; Nakamura, T,期刊:Journal of Biological Chemistry, 页码:13371-13381 , 文章类型: Article,,卷期:2012年287-16]
- Hepatocyte growth factor (HGF), a heterodimer composed of the alpha-chain and beta-chain, exerts multifunctional actions for tissue repair and homeostasis via its receptor, MET. HGF is cleaved by proteases secreted from ...
- Identification of Ubiquitin-specific Protease 9X (USP9X) as a Deubiquitinase Acting on Ubiquitin-Peroxin 5 (PEX5) Thioester Conjugate
[作者:Grou, CP; Francisco, T; Rodrigues, TA; Freitas, MO; Pinto, MP; Carvalho, AF; Domingues, P; Wood, SA; Rodriguez-Borges, JE; Sa-Miranda, C; Fransen, M; Azevedo, JE,期刊:Journal of Biological Chemistry, 页码:12815-12827 , 文章类型: Article,,卷期:2012年287-16]
- Peroxin 5 (PEX5), the peroxisomal protein shuttling receptor, binds newly synthesized peroxisomal matrix proteins in the cytosol and promotes their translocation across the organelle membrane. During the translocation st...
- Biochemical Characterization and N-terminomics Analysis of Leukolysin, the Membrane-type 6 Matrix Metalloprotease (MMP25) CHEMOKINE AND VIMENTIN CLEAVAGES ENHANCE CELL MIGRATION AND MACROPHAGE PHAGOCYTIC ACTIVITIES
[作者:Starr, AE; Bellac, CL; Dufour, A; Goebeler, V; Overall, CM,期刊:Journal of Biological Chemistry, 页码:13382-13395 , 文章类型: Article,,卷期:2012年287-16]
- The neutrophil-specific protease membrane-type 6 matrix metalloproteinase (MT6-MMP)/MMP-25/leukolysin is implicated in multiple sclerosis and cancer yet remains poorly characterized. To characterize the biological roles ...
- Direct Observation of Translocation in Individual DNA Polymerase Complexes
[作者:Dahl, JM; Mai, AH; Cherf, GM; Jetha, NN; Garalde, DR; Marziali, A; Akeson, M; Wang, HY; Lieberman, KR,期刊:Journal of Biological Chemistry, 页码:13407-13421 , 文章类型: Article,,卷期:2012年287-16]
- Complexes of phi29 DNA polymerase and DNA fluctuate on the millisecond time scale between two ionic current amplitude states when captured atop the alpha-hemolysin nanopore in an applied field. The lower amplitude state ...
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