- Molecular Determinants of Ca(v)2.1 Channel Regulation by Calcium-binding Protein-1
[作者:Few, AP; Nanou, E; Scheuer, T; Catterall, WA,期刊:Journal of Biological Chemistry, 页码:41917-41923 , 文章类型: Article,,卷期:2011年286-49]
- Presynaptic Ca(v)2.1 channels, which conduct P/Q-type Ca(2+) currents, initiate synaptic transmission at most synapses in the central nervous system. Regulation of Ca(v)2.1 channels by CaM contributes significantly to sh...
- Juvenile Hormone Regulates Vitellogenin Gene Expression through Insulin-like Peptide Signaling Pathway in the Red Flour Beetle, Tribolium castaneum
[作者:Sheng, ZT; Xu, JJ; Bai, H; Zhu, F; Palli, SR,期刊:Journal of Biological Chemistry, 页码:41924-41936 , 文章类型: Article,,卷期:2011年286-49]
- Our recent studies identified juvenile hormone (JH) and nutrition as the two key signals that regulate vitellogenin (Vg) gene expression in the red flour beetle, Tribolium castaneum. Juvenile hormone regulation of Vg syn...
- Transthiocarbamoylation of Proteins by Thiolated Isothiocyanates
[作者:Shibata, T; Kimura, Y; Mukai, A; Mori, H; Ito, S; Asaka, Y; Oe, S; Tanaka, H; Takahashi, T; Uchida, K,期刊:Journal of Biological Chemistry, 页码:42150-42161 , 文章类型: Article,,卷期:2011年286-49]
- Isothiocyanates, membrane-permeable electrophiles that form adducts with thiols, have been suggested to have important medical benefits. Here we shed light on isothiocyanate-thiol conjugates and studied their electrophil...
- Carbohydrate Metabolism Is Perturbed in Peroxisome-deficient Hepatocytes Due to Mitochondrial Dysfunction, AMP-activated Protein Kinase (AMPK) Activation, and Peroxisome Proliferator-activated Receptor gamma Coactivator 1 alpha (PGC-1 alpha) Suppression
[作者:Peeters, A; Fraisl, P; van den Berg, S; van Themaat, EVL; Van Kampen, A; Rider, MH; Takemori, H; van Dijk, KW; Van Veldhoven, PP; Carmeliet, P; Baes, M,期刊:Journal of Biological Chemistry, 页码:42162-42179 , 文章类型: Article,,卷期:2011年286-49]
- Hepatic peroxisomes are essential for lipid conversions that include the formation of mature conjugated bile acids, the degradation of branched chain fatty acids, and the synthesis of docosahexaenoic acid. Through unreso...
- S1 Pocket of a Bacterially Derived Subtilisin-like Protease Underpins Effective Tissue Destruction
[作者:Wong, W; Wijeyewickrema, LC; Kennan, RM; Reeve, SB; Steer, DL; Reboul, C; Smith, AI; Pike, RN; Rood, JI; Whisstock, JC; Porter, CJ,期刊:Journal of Biological Chemistry, 页码:42180-42187 , 文章类型: Article,,卷期:2011年286-49]
- The ovine footrot pathogen, Dichelobacter nodosus, secretes three subtilisin-like proteases that play an important role in the pathogenesis of footrot through their ability to mediate tissue destruction. Virulent and ben...
- Delayed Re-epithelialization in Ppm1a Gene-deficient Mice Is Mediated by Enhanced Activation of Smad2
[作者:Yang, X; Teng, Y; Hou, N; Fan, XW; Cheng, X; Li, J; Wang, LJ; Wang, YL; Wu, XS; Yang, X,期刊:Journal of Biological Chemistry, 页码:42267-42273 , 文章类型: Article,,卷期:2011年286-49]
- Protein phosphatase magnesium-dependent 1A (PPM1A), a protein serine/threonine phosphatase, controls several signal pathways through cleavage of phosphate from its substrates. However, the in vivo function of Ppm1a in ma...
- Single Molecule Fluorescence Study of the Bacillus thuringiensis Toxin Cry1Aa Reveals Tetramerization
[作者:Groulx, N; McGuire, H; Laprade, R; Schwartz, JL; Blunck, R,期刊:Journal of Biological Chemistry, 页码:42274-42282 , 文章类型: Article,,卷期:2011年286-49]
- Pore-forming toxins constitute a class of potent virulence factors that attack their host membrane in a two- or three-step mechanism. After binding to the membrane, often aided by specific receptors, they form pores in t...
- Size and Conformation Limits to Secretion of Disulfide-bonded Loops in Autotransporter Proteins
[作者:Leyton, DL; Sevastsyanovich, YR; Browning, DF; Rossiter, AE; Wells, TJ; Fitzpatrick, RE; Overduin, M; Cunningham, AF; Henderson, IR,期刊:Journal of Biological Chemistry, 页码:42283-42291 , 文章类型: Article,,卷期:2011年286-49]
- Autotransporters are a superfamily of virulence factors typified by a channel-forming C terminus that facilitates translocation of the functional N-terminal passenger domain across the outer membrane of Gram-negative bac...
- Anti-microRNA-222 (Anti-miR-222) and-181B Suppress Growth of Tamoxifen-resistant Xenografts in Mouse by Targeting TIMP3 Protein and Modulating Mitogenic Signal
[作者:Lu, YZ; Roy, S; Nuovo, G; Ramaswamy, B; Miller, T; Shapiro, C; Jacob, ST; Majumder, S,期刊:Journal of Biological Chemistry, 页码:42292-42302 , 文章类型: Article,,卷期:2011年286-49]
- We have shown earlier that miR-221 and -222 are up-regulated in tamoxifen-resistant MCF-7 (OHT(R)) cells and Her2-positive human breast tumors when compared with Her2 negative tumors. In this study, we report markedly en...
- Cellular Settings Mediating Src Substrate Switching between Focal Adhesion Kinase Tyrosine 861 and CUB-domain-containing protein 1 (CDCP1) Tyrosine 734
[作者:Wortmann, A; He, YW; Christensen, ME; Linn, M; Lumley, JW; Pollock, PM; Waterhouse, NJ; Hooper, JD,期刊:Journal of Biological Chemistry, 页码:42303-42315 , 文章类型: Article,,卷期:2011年286-49]
- Reciprocal interactions between Src family kinases (SFKs) and focal adhesion kinase (FAK) are critical during changes in cell attachment. Recently it has been recognized that another SFK substrate, CUB-domain-containing ...
- PRL-1 Protein Promotes ERK1/2 and RhoA Protein Activation through a Non-canonical Interaction with the Src Homology 3 Domain of p115 Rho GTPase-activating Protein
[作者:Bai, YP; Luo, Y; Liu, SJ; Zhang, LJ; Shen, K; Dong, YS; Walls, CD; Quilliam, LA; Wells, CD; Cao, YJ; Zhang, ZY,期刊:Journal of Biological Chemistry, 页码:42316-42324 , 文章类型: Article,,卷期:2011年286-49]
- Phosphatases of the regenerating liver (PRL) play oncogenic roles in cancer development and metastasis. Although previous studies indicate that PRL-1 promotes cell growth and migration by activating both the ERK1/2 and R...
- Thermally Unstable Gating of the Most Common Cystic Fibrosis Mutant Channel (Delta F508) "RESCUE" BY SUPPRESSOR MUTATIONS IN NUCLEOTIDE BINDING DOMAIN 1 AND BY CONSTITUTIVE MUTATIONS IN THE CYTOSOLIC LOOPS
[作者:Wang, W; Okeyo, GO; Tao, BL; Hong, JS; Kirk, KL,期刊:Journal of Biological Chemistry, 页码:41937-41948 , 文章类型: Article,,卷期:2011年286-49]
- Most cystic fibrosis (CF) cases are caused by the Delta F508 mutation in the CF transmembrane conductance regulator (CFTR), which disrupts both the processing and gating of this chloride channel. The cell surface express...
|