- Interferon Regulatory Factor 3 Attenuates Reovirus Myocarditis and Contributes to Viral Clearance
[作者:Holm, GH; Pruijssers, AJ; Li, LN; Danthi, P; Sherry, B; Dermody, TS,期刊:Journal of virology, 页码:6900-6908 , 文章类型: Article,,卷期:2010年84-14]
- Apoptosis is a pathological hallmark of encephalitis and myocarditis caused by reovirus in newborn mice. In cell culture models, the antiviral transcription factor interferon regulatory factor 3 (IRF-3) enhances reovirus...
- A Limited Number of Simian Immunodeficiency Virus (SIV) env Variants Are Transmitted to Rhesus Macaques Vaginally Inoculated with SIVmac251
[作者:Stone, M; Keele, BF; Ma, ZM; Bailes, E; Dutra, J; Hahn, BH; Shaw, GM; Miller, CJ,期刊:Journal of virology, 页码:7083-7095 , 文章类型: Article,,卷期:2010年84-14]
- Single-genome amplification (SGA) and sequencing of HIV-1 RNA in plasma of acutely infected humans allows the identification and enumeration of transmitted/founder viruses responsible for productive systemic infection. U...
- Multiple Vaccine-Elicited Nonneutralizing Antienvelope Antibody Activities Contribute to Protective Efficacy by Reducing both Acute and Chronic Viremia following Simian/Human Immunodeficiency Virus SHIV89.6P Challenge in Rhesus Macaques
[作者:Xiao, P; Zhao, J; Patterson, LJ; Brocca-Cofano, E; Venzon, D; Kozlowski, PA; Hidajat, R; Demberg, T; Robert-Guroff, M,期刊:Journal of virology, 页码:7161-7173 , 文章类型: Article,,卷期:2010年84-14]
- We have shown that following priming with replicating adenovirus type 5 host range mutant (Ad5hr)-human immunodeficiency virus (HIV)/simian immunodeficiency virus (SIV) recombinants, boosting with gp140 envelope protein ...
- Full-Length Hepatitis B Virus Core Protein Packages Viral and Heterologous RNA with Similarly High Levels of Cooperativity
[作者:Porterfield, JZ; Dhason, MS; Loeb, DD; Nassal, M; Stray, SJ; Zlotnick, A,期刊:Journal of virology, 页码:7174-7184 , 文章类型: Article,,卷期:2010年84-14]
- A critical feature of a viral life cycle is the ability to selectively package the viral genome. In vivo, phosphorylated hepatitis B virus (HBV) core protein specifically encapsidates a complex of pregenomic RNA (pgRNA) ...
- Inefficient Control of Host Gene Expression by the 2009 Pandemic H1N1 Influenza A Virus NS1 Protein
[作者:Hale, BG; Steel, J; Medina, RA; Manicassamy, B; Ye, JQ; Hickman, D; Hai, R; Schmolke, M; Lowen, AC; Perez, DR; Garcia-Sastre, A,期刊:Journal of virology, 页码:6909-6922 , 文章类型: Article,,卷期:2010年84-14]
- In 2009, a novel swine-origin H1N1 influenza A virus emerged. Here, we characterize the multifunctional NS1 protein of this human pandemic virus in order to understand factors that may contribute to replication efficienc...
- Redirecting Lentiviral Vectors Pseudotyped with Sindbis Virus-Derived Envelope Proteins to DC-SIGN by Modification of N-Linked Glycans of Envelope Proteins
[作者:Morizono, K; Ku, A; Xie, YM; Harui, A; Kung, SKP; Roth, MD; Lee, B; Chen, ISY,期刊:Journal of virology, 页码:6923-6934 , 文章类型: Article,,卷期:2010年84-14]
- Redirecting the tropism of viral vectors enables specific transduction of selected cells by direct administration of vectors. We previously developed targeting lentiviral vectors by pseudotyping with modified Sindbis vir...
- Attenuated Bordetella pertussis Protects against Highly Pathogenic Influenza A Viruses by Dampening the Cytokine Storm
[作者:Li, R; Lim, A; Phoon, MC; Narasaraju, T; Ng, JKW; Poh, WP; Sim, MK; Chow, VT; Locht, C; Alonso, S,期刊:Journal of virology, 页码:7105-7113 , 文章类型: Article,,卷期:2010年84-14]
- The threat of a pandemic spread of highly virulent influenza A viruses currently represents a top global public health problem. Mass vaccination remains the most effective way to combat influenza virus. However, current ...
- Deep Sequencing Reveals Highly Complex Dynamics of Human Cytomegalovirus Genotypes in Transplant Patients over Time
[作者:Gorzer, I; Guelly, C; Trajanoski, S; Puchhammer-Stockl, E,期刊:Journal of virology, 页码:7195-7203 , 文章类型: Article,,卷期:2010年84-14]
- In lung transplant patients undergoing immunosuppression, more than one human cytomegalovirus (HCMV) genotype may emerge during follow-up, and this could be critical for the outcome of HCMV infection. Up to now, many cas...
- Epitope Mapping of Ibalizumab, a Humanized Anti-CD4 Monoclonal Antibody with Anti-HIV-1 Activity in Infected Patients
[作者:Song, RJ; Franco, D; Kao, CY; Yu, FY; Huang, YX; Ho, DD,期刊:Journal of virology, 页码:6935-6942 , 文章类型: Article,,卷期:2010年84-14]
Ibalizumab is a humanized monoclonal antibody that binds human CD4, the primary receptor for human immunodeficiency virus type 1 (HIV-1). With its unique specificity for domain 2 of CD4, this antibody potently and bro...
- Intra- and Interhost Evolutionary Dynamics of Equine Influenza Virus
[作者:Murcia, PR; Baillie, GJ; Daly, J; Elton, D; Jervis, C; Mumford, JA; Newton, R; Parrish, CR; Hoelzer, K; Dougan, G; Parkhill, J; Lennard, N; Ormond, D; Moule, S; Whitwham, A; McCauley, JW; McKinley, TJ; Holmes, EC; Grenfell, BT; Wood, JLN,期刊:Journal of virology, 页码:6943-6954 , 文章类型: Article,,卷期:2010年84-14]
- Determining the evolutionary basis of cross-species transmission and immune evasion is key to understanding the mechanisms that control the emergence of either new viruses or novel antigenic variants with pandemic potent...
- Genetically Engineered, Biarsenically Labeled Influenza Virus Allows Visualization of Viral NS1 Protein in Living Cells
[作者:Li, Y; Lu, XY; Li, JW; Berube, N; Giest, KL; Liu, Q; Anderson, DH; Zhou, Y,期刊:Journal of virology, 页码:7204-7213 , 文章类型: Article,,卷期:2010年84-14]
- Real-time fluorescence imaging of viral proteins in living cells provides a valuable means to study virus-host interactions. The challenge of generating replication-competent fluorescent influenza A virus is that the seg...
- Murine Gammaherpesvirus 68 LANA Is Essential for Virus Reactivation from Splenocytes but Not Long-Term Carriage of Viral Genome
[作者:Paden, CR; Forrest, JC; Moorman, NJ; Speck, SH,期刊:Journal of virology, 页码:7214-7224 , 文章类型: Article,,卷期:2010年84-14]
- ORF73, which encodes the latency-associated nuclear antigen (LANA), is a conserved gamma-2-herpesvirus gene. The murine gammaherpesvirus 68 (MHV68) LANA (mLANA) is critical for efficient virus replication and the establi...
- OrfA Downregulates Feline Immunodeficiency Virus Primary Receptor CD134 on the Host Cell Surface and Is Important in Viral Infection
[作者:Hong, Y; Fink, E; Hu, QY; Kiosses, WB; Elder, JH,期刊:Journal of virology, 页码:7225-7232 , 文章类型: Article,,卷期:2010年84-14]
- Feline immunodeficiency virus (FIV) OrfA is an accessory protein that is critical for productive viral replication and infection in T cells. Here, we show that OrfA acts to markedly reduce cell surface expression of the ...
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