- Evaluation of Replication and Cross-Reactive Antibody Responses of H2 Subtype Influenza Viruses in Mice and Ferrets
[作者:Chen, GL; Lamirande, EW; Yang, CF; Jin, H; Kemble, G; Subbarao, K,期刊:Journal of virology, 页码:7695-7702 , 文章类型: Article,,卷期:2010年84-15]
- H2 influenza viruses have not circulated in humans since 1968, and therefore a large segment of the population would likely be susceptible to infection should H2 influenza viruses reemerge. The development of an H2 pande...
- Upregulation of the Chemokine (C-C Motif) Ligand 2 via a Severe Acute Respiratory Syndrome Coronavirus Spike-ACE2 Signaling Pathway
[作者:Chen, IY; Chang, SC; Wu, HY; Yu, TC; Wei, WC; Lin, SM; Chien, CL; Chang, MF,期刊:Journal of virology, 页码:7703-7712 , 文章类型: Article,,卷期:2010年84-15]
- Severe acute respiratory syndrome coronavirus (SARS-CoV) was identified to be the causative agent of SARS with atypical pneumonia. Angiotensin-converting enzyme 2 (ACE2) is the major receptor for SARS-CoV. It is not clea...
- In Vitro and In Vivo Characterization of MicroRNA-Targeted Alphavirus Replicon and Helper RNAs
[作者:Kamrud, KI; Coffield, VM; Owens, G; Goodman, C; Alterson, K; Custer, M; Murphy, MA; Lewis, W; Timberlake, S; Wansley, EK; Berglund, P; Smith, J,期刊:Journal of virology, 页码:7713-7725 , 文章类型: Article,,卷期:2010年84-15]
- Alphavirus-based replicon vector systems (family Togaviridae) have been developed as expression vectors with demonstrated potential in vaccine development against both infectious diseases and cancer. The single-cycle nat...
- A Spread-Deficient Cytomegalovirus for Assessment of First-Target Cells in Vaccination
[作者:Mohr, CA; Arapovic, J; Muhlbach, H; Panzer, M; Weyn, A; Dolken, L; Krmpotic, A; Voehringer, D; Ruzsics, Z; Koszinowski, U; Sacher, T,期刊:Journal of virology, 页码:7730-7742 , 文章类型: Article,,卷期:2010年84-15]
- Human cytomegalovirus (HCMV) is a human pathogen that causes severe disease primarily in the immunocompromised or immunologically immature individual. To date, no vaccine is available. We describe use of a spread-deficie...
- High Prevalence, Coinfection Rate, and Genetic Diversity of Retroviruses in Wild Red Colobus Monkeys (Piliocolobus badius badius) in Tai National Park, Cote d'Ivoire
[作者:Leendertz, SAJ; Junglen, S; Hedemann, C; Goffe, A; Calvignac, S; Boesch, C; Leendertz, FH,期刊:Journal of virology, 页码:7427-7436 , 文章类型: Article,,卷期:2010年84-15]
- Simian retroviruses are precursors of all human retroviral pathogens. However, little is known about the prevalence and coinfection rates or the genetic diversity of major retroviruses-simian immunodeficiency virus (SIV)...
- HIV-1 Protease Has a Genetic T-Cell Adjuvant Effect Which Is Negatively Regulated by Proteolytic Activity
[作者:Kim, KS; Jin, DB; Ahn, SS; Park, KS; Seo, SH; Suh, YS; Sung, YC,期刊:Journal of virology, 页码:7743-7749 , 文章类型: Article,,卷期:2010年84-15]
- HIV protease (PR) mediates the processing of human immunodeficiency virus (HIV) polyproteins and is necessary for the viral production. Recently, HIV PR was shown to possess both cytotoxic and chaperonelike activity. We ...
- Autographa californica Multiple Nucleopolyhedrovirus ac76 Is Involved in Intranuclear Microvesicle Formation
[作者:Hu, ZY; Yuan, MJ; Wu, WB; Liu, C; Yang, K; Pang, Y,期刊:Journal of virology, 页码:7437-7447 , 文章类型: Article,,卷期:2010年84-15]
- In this study, we characterized Autographa californica multiple nucleopolyhedrovirus (AcMNPV) orf76 (ac76), which is a highly conserved gene of unknown function in lepidopteran baculoviruses. Transcriptional analysis of ...
- Intradermal Vaccination with Influenza Virus-Like Particles by Using Microneedles Induces Protection Superior to That with Intramuscular Immunization
[作者:Quan, FS; Kim, YC; Vunnava, A; Yoo, DG; Song, JM; Prausnitz, MR; Compans, RW; Kang, SM,期刊:Journal of virology, 页码:7760-7769 , 文章类型: Article,,卷期:2010年84-15]
- Influenza virus-like particles (VLPs) are a promising cell culture-based vaccine, and the skin is considered an attractive immunization site. In this study, we examined the immunogenicity and protective efficacy of influ...
- Respiratory Syncytial Virus Engineered To Express the Cystic Fibrosis Transmembrane Conductance Regulator Corrects the Bioelectric Phenotype of Human Cystic Fibrosis Airway Epithelium In Vitro
[作者:Kwilas, AR; Yednak, MA; Zhang, LQ; Liesman, R; Collins, PL; Pickles, RJ; Peeples, ME,期刊:Journal of virology, 页码:7770-7781 , 文章类型: Article,,卷期:2010年84-15]
- Cystic fibrosis (CF) is the most common lethal recessive genetic disease in the Caucasian population. It is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that is normally expressed in cili...
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