- Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation
[作者:Sun, JP; Chen, H; Chen, C; Whitsett, JA; Mishina, Y; Bringas, P; Ma, JC; Warburton, D; Shi, W,期刊:American Journal of Pathology, 页码:571-582 , 文章类型: Article,,卷期:2008年172-3]
- Bone morphogenetic proteins (BMPs) play important roles in regulating lung development and function although the endogenous regulatory effects of BMP signaling are still controversial. We found that BMP type I receptor A...
- A role for the receptor for advanced glycation end products in idiopathic pulmonary fibrosis
[作者:Englert, JM; Hanford, LE; Kaminski, N; Tobolewski, JM; Tan, RJ; Fattman, CL; Ramsgaard, L; Richards, TJ; Loutaev, I; Nawroth, PP; Kasper, M; Bierhaus, A; Oury, TD,期刊:American Journal of Pathology, 页码:583-591 , 文章类型: Article,,卷期:2008年172-3]
- Idiopathic pulmonary fibrosis (IPF) is a severely debilitating disease associated with a dismal prognosis. There are currently no effective therapies for IPF, thus the identification of novel therapeutic targets is great...
- Endothelial cysteinyl leukotriene 2 receptor expression mediates myocardial ischemia-reperfusion injury
[作者:Jiang, W; Hall, SR; Moos, MPW; Cao, RY; Ishii, S; Ogunyankin, KO; Melo, LG; Funk, CD,期刊:American Journal of Pathology, 页码:592-602 , 文章类型: Article,,卷期:2008年172-3]
- Cysteinyl leukotrienes (CysLTs) have been implicated as inflammatory mediators of cardiovascular disease. Three distinct CysLT receptor subtypes transduce the actions of CysLTs but the role of the endothelial CysLT, rece...
- Resistance of chemokine receptor 6-deficient mice to Yersinia enterocolitica infection - Evidence of defective m-cell formation in vivo
[作者:Westphal, S; Luegering, A; von Wedel, J; von Eiff, C; Maaser, C; Spahn, T; Heusipp, G; Schmidt, MA; Herbst, H; Williams, IR; Domschke, W; Kucharzik, T,期刊:American Journal of Pathology, 页码:671-680 , 文章类型: Article,,卷期:2008年172-3]
- M cells, specialized cells within Peyer's patches (PPs), are reduced in number in chemokine receptor 6 (CCR6)-deficient mice. The pathogenic microorganism Yersinia enterocolitica exploits M cells for the purpose of mucos...
- Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, fasudil, through podocyte protection and prevention of leukocyte migration
[作者:Hidaka, T; Suzuki, Y; Yamashita, M; Shibata, T; Tanaka, Y; Horikoshi, S; Tomino, Y,期刊:American Journal of Pathology, 页码:603-614 , 文章类型: Article,,卷期:2008年172-3]
- The small GTPase RhoA is activated by the angiotensin II (AngII) type 1 receptor (AT1R), which is part of the local renin-angiotensin system that is involved in podocyte injury preceding glomerular crescent formation. We...
- Circulating angiogenic precursors in idiopathic pulmonary arterial hypertension
[作者:Asosingh, K; Aldred, MA; Vasanji, A; Drazba, J; Sharp, J; Farver, C; Comhair, SAA; Xu, WL; Licina, L; Huang, L; Anand-Apte, B; Yoder, MC; Tuder, RM; Erzurum, SC,期刊:American Journal of Pathology, 页码:615-627 , 文章类型: Article,,卷期:2008年172-3]
- Vascular remodeling in idiopathic pulmonary arterial hypertension (IPAH) involves hyperproliferative and apoptosis-resistant pulmonary artery endothelial cells. In this study, we evaluated the relative contribution of bo...
- Essential role of plasminogen activator inhibitor type-1 in radiation enteropathy
[作者:Milliat, F; Sabourin, JC; Tarlet, G; Holler, V; Deutsch, E; Buard, V; Tamarat, R; Atfi, A; Benderitter, M; Francois, A,期刊:American Journal of Pathology, 页码:691-701 , 文章类型: Article,,卷期:2008年172-3]
- intestinal radiation injury is a dose-limiting factor in radiation therapy for abdominal and pelvic cancers. Because transforming growth factor-beta 1 is a key mediator involved in radiation-induced damage, we hypothesiz...
- Late onset of Cc12 blockade with the spiegelmer mNOX-E36-3 ' PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice
[作者:Ninichuk, V; Clauss, S; Kulkarni, O; Schmid, H; Segerer, S; Radomska, E; Eulberg, D; Buchner, K; Selve, N; Klussmann, S; Anders, HJ,期刊:American Journal of Pathology, 页码:628-637 , 文章类型: Article,,卷期:2008年172-3]
- Diabetic kidney disease is associated with monocyte chemoattractant CC chemokine ligand 2 (CCL2)-dependent glomerular and interstitial macrophage recruitment. In addition, nephropathy is delayed in Cc12 mutant diabetic m...
- Excess FGF-7 in corneal epithelium causes corneal intraepithelial neoplasia in young mice and epithelium hyperplasia in adult mice
[作者:Chikama, T; Liu, CY; Meij, JTA; Hayashi, Y; Wang, IJ; Yang, L; Nishida, T; Kao, WWY,期刊:American Journal of Pathology, 页码:638-649 , 文章类型: Article,,卷期:2008年172-3]
- We hypothesized that human ocular surface squamous neoplasia (OSSN) may result from the continuous growth stimulation of corneal epithelial progenitor cells. in the present study, we analyzed the effects of excess fibrob...
- Murine cytomegalovirus influences Foxj1 expression, ciliogenesis, and mucus plugging in mice with allergic airway disease
[作者:Wu, CA; Peluso, JJ; Shanley, JD; Puddington, L; Thrall, RS,期刊:American Journal of Pathology, 页码:714-724 , 文章类型: Article,,卷期:2008年172-3]
- We have followed throughout time the development of allergic airway disease (AAD) in both uninfected mice and mice infected intranasally with murine cytomegalovirus (MCMV). Histological evaluation of lung tissue from uni...
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