- Increased Whole-Body and Sustained Liver Cortisol Regeneration by 11 beta-Hydroxysteroid Dehydrogenase Type 1 in Obese Men With Type 2 Diabetes Provides a Target for Enzyme Inhibition
[作者：Stimson, RH; Andrew, R; McAvoy, NC; Tripathi, D; Hayes, PC; Walker, BR,期刊：Diabetes, 页码：720-725 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE-The cortisol-regenerating enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) amplifies glucocorticoid levels in liver and adipose tissue. 11 beta-HSD1 inhibitors are being developed to treat type...
- Identification of Metabolic Modifiers That Underlie Phenotypic Variations in Energy-Balance Regulation
[作者：Chang, CL; Cai, JJ; Cheng, PJ; Chueh, HY; Hsu, SYT,期刊：Diabetes, 页码：726-734 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE-Although recent studies have shown that human genomes contain hundreds of loci that exhibit signatures of positive selection, variants that are associated with adaptation in energy-balance regulation remain elu...
- Global Gene Expression Profiles of Subcutaneous Adipose and Muscle From Glucose-Tolerant, Insulin-Sensitive, and Insulin-Resistant Individuals Matched for BMI
[作者：Elbein, SC; Kern, PA; Rasouli, N; Yao-Borengasser, A; Sharma, NK; Das, SK,期刊：Diabetes, 页码：1019-1029 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE-To determine altered gene expression profiles in subcutaneous adipose and skeletal muscle from nondiabetic, insulin-resistant individuals compared with insulin-sensitive individuals matched for BMI. RESEARCH DE...
- Tests for Genetic Interactions in Type 1 Diabetes Linkage and Stratification Analyses of 4,422 Affected Sib-Pairs
[作者：Morahan, G; Mehta, M; James, I; Chen, WM; Akolkar, B; Erlich, HA; Hilner, JE; Julier, C; Nerup, J; Nierras, C; Pociot, F; Todd, JA; Rich, SS,期刊：Diabetes, 页码：1030-1040 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE-Interactions between genetic and environmental factors lead to immune dysregulation causing type 1 diabetes and other autoimmune disorders. Recently, many common genetic variants have been associated with type ...
- Deletion of Lkb1 in Pro-Opiomelanocortin Neurons Impairs Peripheral Glucose Homeostasis in Mice
[作者：Claret, M; Smith, MA; Knauf, C; Al-Qassab, H; Woods, A; Heslegrave, A; Piipari, K; Emmanuel, JJ; Colom, A; Valet, P; Cani, PD; Begum, G; White, A; Mucket, P; Peters, M; Mizuno, K; Batterham, RL; Giese, KP; Ashworth, A; Burcelin, R; Ashford, ML; Carling, D; Withers, DJ,期刊：Diabetes, 页码：735-745 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE AMP-activated protein kinase (AMPK) signaling acts as a sensor of nutrients and hormones in the hypothalamus, thereby regulating whole-body energy homeostasis. Deletion of Ampk alpha 2 in pro-opiomelanocortin (...
- Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways
[作者：Xiao, F; Huang, ZY; Li, HK; Yu, JJ; Wang, CX; Chen, SH; Meng, QS; Cheng, Y; Gao, XA; Li, J; Liu, Y; Guo, FF,期刊：Diabetes, 页码：746-756 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE-We have previously shown that serum insulin levels decrease threefold and blood glucose levels remain normal in mice fed a leucine-deficient diet, suggesting increased insulin sensitivity. The goal of the curre...
- An Allele of IKZF1 (Ikaros) Conferring Susceptibility to Childhood Acute Lymphoblastic Leukemia Protects Against Type 1 Diabetes
[作者：Swafford, ADE; Howson, JMM; Davison, LJ; Wallace, C; Smyth, DJ; Schuilenburg, H; Maisuria-Armer, M; Mistry, T; Lenardo, MJ; Tod, JA,期刊：Diabetes, 页码：1041-1044 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE-IKZF1 encoding Ikaros, an essential regulator of lymphopoiesis and immune homeostasis, has been implicated in the development of childhood acute lymphoblastic leukemia (C-ALL). Because recent genome-wide associ...
- Polymerase I and Transcript Release Factor Regulates Lipolysis via a Phosphorylation-Dependent Mechanism
[作者：Aboulaich, N; Chui, PC; Asara, JM; Flier, JS; Maratos-Flier, E,期刊：Diabetes, 页码：757-765 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE-Polymerase I and transcript release factor (PTRF) is a protein highly expressed in adipose tissue and is an integral structural component of caveolae. Here, we report on a novel role of PTRF in lipid mobilizati...
- Molecular Mechanism by Which AMP-Activated Protein Kinase Activation Promotes Glycogen Accumulation in Muscle
[作者：Hunter, RW; Treebak, JT; Wojtaszewski, JFP; Sakamoto, K,期刊：Diabetes, 页码：766-774 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE During energy stress, AMP-activated protein kinase (AMPK) promotes glucose transport and glycolysis for ATP production, while it is thought to inhibit anabolic glycogen synthesis by suppressing the activity of ...
- Inflammatory Induction of Human Resistin Causes Insulin Resistance in Endotoxemic Mice
[作者：Park, HK; Qatanani, M; Briggs, ER; Ahima, RS; Lazar, MA,期刊：Diabetes, 页码：775-783 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE-Although adipocyte-derived murine resistin links insulin resistance to obesity, the role of human resistin, predominantly expressed in mononuclear cells and induced by inflammatory signals, remains unclear. Giv...
- Physical Exercise Reduces Circulating Lipopolysaccharide and TLR4 Activation and Improves Insulin Signaling in Tissues of DIO Rats
[作者：Oliveira, AG; Carvalho, BM; Tobar, N; Ropelle, ER; Pauli, JR; Bagarolli, RA; Guadagnini, D; Carvalheira, JBC; Saad, MJA,期刊：Diabetes, 页码：784-796 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE-Insulin resistance in diet-induced obesity (DIO) is associated with a chronic systemic low-grade inflammation, and Toll-like receptor 4 (TLR4) plays an important role in the link among insulin resistance, infla...
- Differential Lipid Partitioning Between Adipocytes and Tissue Macrophages Modulates Macrophage Lipotoxicity and M2/M1 Polarization in Obese Mice
[作者：Prieur, X; Mok, CYL; Velagapudi, VR; Nunez, V; Fuentes, L; Montaner, D; Ishikawa, K; Camacho, A; Barbarroja, N; O'Rahilly, S; Sethi, JK; Dopazo, J; Oresic, M; Ricote, M; Vidal-Puig, A,期刊：Diabetes, 页码：797-809 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE-Obesity-associated insulin resistance is characterized by a state of chronic, low-grade inflammation that is associated with the accumulation of M1 proinflammatory macrophages in adipose tissue. Although differ...
- Diet and Gastrointestinal Bypass-Induced Weight Loss The Roles of Ghrelin and Peptide YY
[作者：Chandarana, K; Gelegen, C; Karra, E; Choudhury, AI; Drew, ME; Fauveau, V; Viollet, B; Andreelli, F; Withers, DJ; Batterham, RL,期刊：Diabetes, 页码：810-818 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE-Bariatric surgery causes durable weight loss. Gut hormones are implicated in obesity pathogenesis, dietary failure, and mediating gastrointestinal bypass (GIBP) surgery weight loss. In mice, we determined the e...
- Increased Expression of Macrophage-Inducible C-type Lectin in Adipose Tissue of Obese Mice and Humans
[作者：Ichioka, M; Suganami, T; Tsuda, N; Shirakawa, I; Hirata, Y; Satoh-Asahara, N; Shimoda, Y; Tanaka, M; Kim-Saijo, M; Miyamoto, Y; Kamei, Y; Sata, M; Ogawa, Y,期刊：Diabetes, 页码：819-826 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE-We have provided evidence that saturated fatty acids, which are released from adipocytes via macrophage-induced adipocyte lipolysis, serve as a naturally occurring ligand for the Toll-like receptor (TLR) 4 comp...
- Rictor/mTORC2 Is Essential for Maintaining a Balance Between beta-Cell Proliferation and Cell Size
[作者：Gu, YY; Lindner, J; Kumar, A; Yuan, WP; Magnuson, MA,期刊：Diabetes, 页码：827-837 , 文章类型： Article，,卷期：2011年60-3]
- OBJECTIVE-We examined the role of Rictor/mammalian target of rapamycin complex 2 (mTORC2), a key component of the phosphotidylinositol-3-kinase (PI3K)/mTORC2/AKT signaling pathway, in regulating both beta-cell mass and f...
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