- Development of Small-Molecule PUMA Inhibitors for Mitigating Radiation-Induced Cell Death
[作者:Mustata, G; Li, M; Zevola, N; Bakan, A; Zhang, L; Epperly, M; Greenberger, JS; Yu, J; Bahar, I,期刊:Current Topics in Medicinal Chemistry, 页码:281-290 , 文章类型: Review,,卷期:2011年11-3]
- PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2 family member and a key mediator of apoptosis induced by a wide variety of stimuli. PUMA is particularly important in initiating radiat...
- Modulation of Protein-Protein Interactions as a Therapeutic Strategy for the Treatment of Neurodegenerative Tauopathies
[作者:Ballatore, C; Brunden, KR; Trojanowski, JQ; Lee, VMY; Smith, AB; Huryn, DM,期刊:Current Topics in Medicinal Chemistry, 页码:317-330 , 文章类型: Review,,卷期:2011年11-3]
- The recognition that malfunction of the microtubule (MT) associated protein tau is likely to play a defining role in the onset and/or progression of a number of neurodegenerative diseases, including Alzheimer's disease, ...
|