- Synthetic and Natural Products as Iron Chelators
[作者：Sharpe, PC; Richardson, DR; Kalinowski, DS; Bernhardt, PV,期刊：Current Topics in Medicinal Chemistry, 页码：591-607 , 文章类型： Review，,卷期：2011年11-5]
- An evaluation of existing and proposed Fe chelators, both synthetic and natural products, for the treatment of Fe-overload disease must address a number of issues. There are fundamental parameters that determine the effi...
- The Medicinal Chemistry of Novel Iron Chelators for the Treatment of Cancer
[作者：Kovacevic, Z; Kalinowski, DS; Lovejoy, DB; Yu, Y; Rahmanto, YS; Sharpe, PC; Bernhardt, PV; Richardson, DR,期刊：Current Topics in Medicinal Chemistry, 页码：483-499 , 文章类型： Review，,卷期：2011年11-5]
- Cancer is one of the leading causes of death worldwide and there is an increasing need for novel anti-tumor therapeutics with greater selectivity and potency. A new strategy in the treatment of cancer has focused on targ...
- Transition Metal Based Anticancer Drugs
[作者：Garbutcheon-Singh, KB; Grant, MP; Harper, BW; Krause-Heuer, AM; Manohar, M; Orkey, N; Aldrich-Wright, JR,期刊：Current Topics in Medicinal Chemistry, 页码：521-542 , 文章类型： Review，,卷期：2011年11-5]
- With an ageing baby-boomer population in the Western World, cancer is becoming a significant cause of death. The prevalence of cancer and all associated costs, both in human and financial terms, drives the search for new...
- Reorganizing Metals: the Use of Chelating Compounds as Potential Therapies for Metal-Related Neurodegenerative Disease
[作者：Badrick, AC; Jones, CE,期刊：Current Topics in Medicinal Chemistry, 页码：543-552 , 文章类型： Review，,卷期：2011年11-5]
- Metal ions, particularly copper, zinc and iron, are implicated in several amyloidogenic neurodegenerative disorders. In the brain, as elsewhere in the body, metal ion excess or deficiency can potentially inhibit protein ...
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