- Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty
[作者：Magee, JA; Piskounova, E; Morrison, SJ,期刊：Cancer Cell, 页码：283-296 , 文章类型： Article，,卷期：2012年21-3]
- The differentiation of tumorigenic cancer stem cells into nontumorigenic cancer cells confers heterogeneity to some cancers beyond that explained by clonal evolution or environmental differences. In such cancers, functio...
- Targeting Epigenetic Misregulation in Synovial Sarcoma
[作者：Waterfall, JJ; Meltzer, PS,期刊：Cancer Cell, 页码：323-324 , 文章类型： Editorial Material，,卷期：2012年21-3]
- Like many sarcomas, synovial sarcoma is driven by a characteristic oncogenic transcription factor fusion, SS18-SSX. In this issue of Cancer Cell, Su et al. elucidate the protein partners necessary for target gene misregu...
- ALK and MYCN: When Two Oncogenes Are Better than One
[作者：Liu, ZH; Thiele, CJ,期刊：Cancer Cell, 页码：325-326 , 文章类型： Editorial Material，,卷期：2012年21-3]
- Mutations of ALK are frequently observed in MYCN-amplified neuroblastomas and correlate with poor clinical outcome, but how these oncogenes cooperate in neuroblastoma development remains unclear. In this issue of Cancer ...
- A Tell-Tail Sign of Chromatin: Histone Mutations Drive Pediatric Glioblastoma
[作者：Rheinbay, E; Louis, DN; Bernstein, BE; Suva, ML,期刊：Cancer Cell, 页码：329-331 , 文章类型： Editorial Material，,卷期：2012年21-3]
- Recent genomic analyses of pediatric glioblastoma, a poorly understood tumor with dismal outcome, have identified mutations in histone H3 variants that affect critical amino acids in the tail. The findings extend discove...
- Deconstruction of the SS18-SSX Fusion Oncoprotein Complex: Insights into Disease Etiology and Therapeutics
[作者：Su, L; Sampaio, AV; Jones, KB; Pacheco, M; Goytain, A; Lin, SJ; Poulin, N; Yi, L; Rossi, FM; Kast, J; Capecchi, MR; Underhil, TM; Nielsen, TO,期刊：Cancer Cell, 页码：333-347 , 文章类型： Article，,卷期：2012年21-3]
- Synovial sarcoma is a translocation-associated sarcoma where the underlying chromosomal event generates SS18-SSX fusion transcripts. In vitro and in vivo studies have shown that the SS18-SSX fusion oncoprotein is both ne...
- NKX2-1/TITF1/TTF-1-Induced ROR1 Is Required to Sustain EGFR Survival Signaling in Lung Adenocarcinoma
[作者：Yamaguchi, T; Yanagisawa, K; Sugiyama, R; Hosono, Y; Shimada, Y; Arima, C; Kato, S; Tomida, S; Suzuki, M; Osada, H; Takahashi, T,期刊：Cancer Cell, 页码：348-361 , 文章类型： Article，,卷期：2012年21-3]
- We and others previously identified NKX2-1, also known as TITF1 and TTF-1, as a lineage-survival oncogene in lung adenocarcinomas. Here we show that NKX2-1 induces the expression of the receptor tyrosine kinase-like orph...
- Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis
[作者：Zhu, SZ; Lee, JS; Guo, F; Shin, J; Perez-Atayde, AR; Kutok, JL; Rodig, SJ; Neuberg, DS; Helman, D; Feng, H; Stewart, RA; Wang, WC; George, RE; Kanki, JP; Look, AT,期刊：Cancer Cell, 页码：362-373 , 文章类型： Article，,卷期：2012年21-3]
- Amplification of the MYCN oncogene in childhood neuroblastoma is often accompanied by mutational activation of ALK (anaplastic lymphoma kinase), suggesting their pathogenic cooperation. We generated a transgenic zebrafis...
- The Crosstalk of mTOR/S6K1 and Hedgehog Pathways
[作者：Wang, Y; Ding, QQ; Yen, CJ; Xia, WY; Izzo, JG; Lang, JY; Li, CW; Hsu, JL; Miller, SA; Wang, XM; Lee, DF; Hsu, JM; Huo, LF; LaBaff, AM; Liu, DP; Huang, TH; Lai, CC; Tsai, FJ; Chang, WC; Chen, CH; Wu, TT; Buttar, NS; Wang, KK; Wu, Y; Wang, HM; Ajani, J; Hung, MC,期刊：Cancer Cell, 页码：374-387 , 文章类型： Article，,卷期：2012年21-3]
- Esophageal adenocarcinoma (EAC) is the most prevalent esophageal cancer type in the United States. The TNF-alpha/mTOR pathway is known to mediate the development of EAC. Additionally, aberrant activation of Gli1, downstr...
- Treatment-Emergent Mutations in NAE beta Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924
[作者：Milhollen, MA; Thomas, MP; Narayanan, U; Traore, T; Riceberg, J; Amidon, BS; Bence, NF; Bolen, JB; Brownell, J; Dick, LR; Loke, HK; McDonald, AA; Ma, JY; Manfredi, MG; Sells, TB; Sintchak, MD; Yang, XF; Xu, Q; Koenig, EM; Gavin, JM; Smith, PG,期刊：Cancer Cell, 页码：388-401 , 文章类型： Article，,卷期：2012年21-3]
- MLN4924 is an investigational small-molecule inhibitor of NEDD8-activating enzyme (NAE) in clinical trials for the treatment of cancer. MLN4924 is a mechanism-based inhibitor, with enzyme inhibition occurring through the...
- Marginating Dendritic Cells of the Tumor Microenvironment Cross-Present Tumor Antigens and Stably Engage Tumor-Specific T Cells
[作者：Engelhardt, JJ; Boldajipour, B; Beemiller, P; Pandurangi, P; Sorensen, C; Werb, Z; Egeblad, M; Krummel, MF,期刊：Cancer Cell, 页码：402-417 , 文章类型： Article，,卷期：2012年21-3]
- The nature and site of tumor-antigen presentation to immune T cells by bone-marrow-derived cells within the tumor microenvironment remains unresolved. We generated a fluorescent mouse model of spontaneous immunoevasive b...
- Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma
[作者：Provenzano, PP; Cuevas, C; Chang, AE; Goel, VK; Von Hoff, DD; Hingorani, SR,期刊：Cancer Cell, 页码：418-429 , 文章类型： Article，,卷期：2012年21-3]
- Pancreatic ductal adenocarcinomas (PDAs) are characterized by a robust fibroinflammatory response. We show here that this desmoplastic reaction generates inordinately high interstitial fluid pressures (IFPs), exceeding t...
- Transient Low Doses of DNA-Demethylating Agents Exert Durable Antitumor Effects on Hematological and Epithelial Tumor Cells
[作者：Tsai, HC; Li, HL; Van Neste, L; Cai, Y; Robert, C; Rassool, FV; Shin, JJ; Harbom, KM; Beaty, R; Pappou, E; Harris, J; Yen, RWC; Ahuja, N; Brock, MV; Stearns, V; Feller-Kopman, D; Yarmus, LB; Lin, YC; Welm, AL; Issa, JP; Minn, I; Matsui, W; Jang, YY; Sharkis, SJ; Baylin, SB; Zahnow, CA,期刊：Cancer Cell, 页码：430-446 , 文章类型： Article，,卷期：2012年21-3]
- Reversal of promoter DNA hypermethylation and associated gene silencing is an attractive cancer therapy approach. The DNA methylation inhibitors decitabine and azacitidine are efficacious for hematological neoplasms at l...
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