- Crystal Structures of Mutant IspH Proteins Reveal a Rotation of the Substrate's Hydroxymethyl Group during Catalysis
[作者:Span, I; Grawert, T; Bacher, A; Eisenreich, W; Groll, M,期刊:Journal of Molecular Biology, 页码:1-9 , 文章类型: Article,,卷期:2012年416-1]
- Isoprenoids derive from two universal precursors, isopentenyl diphosphate and dimethylallyl diphosphate, which in most human pathogens are synthesized in the deoxyxylulose phosphate pathway. The last step of this pathway...
- Basic N-Terminus of Yeast Nhp6A Regulates the Mechanism of Its DNA Flexibility Enhancement
[作者:Zhang, JY; McCauley, MJ; Maher, LJ; Williams, MC; Israeloff, NE,期刊:Journal of Molecular Biology, 页码:10-20 , 文章类型: Article,,卷期:2012年416-1]
- HMGB (high-mobility group box) proteins are members of a class of small proteins that are ubiquitous in eukaryotic cells and nonspecifically bind to DNA, inducing large-angle DNA bends, enhancing the flexibility of DNA, ...
- The Transition of Human Estrogen Sulfotransferase from Generalist to Specialist Using Directed Enzyme Evolution
[作者:Amar, D; Berger, I; Amara, N; Tafa, G; Meijler, MM; Aharoni, A,期刊:Journal of Molecular Biology, 页码:21-32 , 文章类型: Article,,卷期:2012年416-1]
- Broad specificity is believed to be a property of primordial enzymes that diverged during natural protein evolution to produce highly specific and efficient enzymes. Human estrogen sulfotransferase (SULT1E1) is a broad-s...
- Short Peptides Act as Inducers, Anti-Inducers and Corepressors of Tet Repressor
[作者:Goeke, D; Kaspar, D; Stoeckle, C; Grubmuller, S; Berens, C; Klotzsche, M; Ilen, WH,期刊:Journal of Molecular Biology, 页码:33-45 , 文章类型: Article,,卷期:2012年416-1]
- Protein allostery plays a pivotal role in many regulatory processes. Prominent examples are cell-surface receptors, which allosterically transmit ligand-generated signals to their cytoplasmic domains, or bacterial transc...
- An Exclusive alpha/beta Code Directs Allostery in TetR-Peptide Complexes
[作者:Sevvana, M; Goetz, C; Goeke, D; Wimmer, C; Berens, C; Hillen, W; Muller, YA,期刊:Journal of Molecular Biology, 页码:46-56 , 文章类型: Article,,卷期:2012年416-1]
- The allosteric mechanism of one of the best characterized bacterial transcription regulators, tetracycline repressor (TetR), has recently been questioned. Tetracycline binding induces cooperative folding of TetR, as sugg...
- Ligand Binding and Membrane Insertion Compete with Oligomerization of the BcIXL Apoptotic Repressor
[作者:Bhat, V; McDonald, CB; Mikles, DC; Deegan, BJ; Seldeen, KL; Bates, ML; Farooq, A,期刊:Journal of Molecular Biology, 页码:57-77 , 文章类型: Article,,卷期:2012年416-1]
- B-cell lymphoma extra large (BclXL) apoptotic repressor plays a central role in determining the fate of cells to live or die during physiological processes such as embryonic development and tissue homeostasis. Herein, us...
- (phi,psi)(2) Motifs: A Purely Conformation-Based Fine-Grained Enumeration of Protein Parts at the Two-Residue Level
[作者:Hollingsworth, SA; Lewis, MC; Berkholz, DS; Wong, WK; Karplus, PA,期刊:Journal of Molecular Biology, 页码:78-93 , 文章类型: Article,,卷期:2012年416-1]
- A deep understanding of protein structure benefits from the use of a variety of classification strategies that enhance our ability to effectively describe local patterns of conformation. Here, we use a clustering algorit...
- Engineering Antibody Fitness and Function Using Membrane-Anchored Display of Correctly Folded Proteins
[作者:Karlsson, AJ; Lim, HK; Xu, HS; Rocco, MA; Bratkowski, MA; Ke, AL; DeLisa, MP,期刊:Journal of Molecular Biology, 页码:94-107 , 文章类型: Article,,卷期:2012年416-1]
- A hallmark of the bacterial twin-arginine translocation (Tat) pathway is its ability to export folded proteins. Here, we discovered that overexpressed Tat substrate proteins form two distinct, long-lived translocation in...
- NMR Characterization of Monomeric and Oligomeric Conformations of Human Calcitonin and Its Interaction with EGCG
[作者:Huang, R; Vivekanandan, S; Brender, JR; Abe, Y; Naito, A; Ramamoorthy, A,期刊:Journal of Molecular Biology, 页码:108-120 , 文章类型: Article,,卷期:2012年416-1]
- Calcitonin is a 32-residue peptide hormone known for its hypocalcemic effect and its inhibition of bone resorption. While calcitonin has been used in therapy for osteoporosis and Paget's disease for decades, human calcit...
- Dissection of the Network of Interactions That Links RNA Processing with Glycolysis in the Bacillus subtilis Degradosome
[作者:Newman, JA; Hewitt, L; Rodrigues, C; Solovyova, AS; Harwood, CR; Lewis, RJ,期刊:Journal of Molecular Biology, 页码:121-136 , 文章类型: Article,,卷期:2012年416-1]
- The RNA degradosome is a multiprotein macromolecular complex that is involved in the degradation of messenger RNA in bacteria. The composition of this complex has been found to display a high degree of evolutionary diver...
- Two Immunoglobulin Tandem Proteins with a Linking beta-Strand Reveal Unexpected Differences in Cooperativity and Folding Pathways
[作者:Steward, A; Chen, Q; Chapman, RI; Borgia, MB; Rogers, JM; Wojtala, A; Wilmanns, M; Clarke, J,期刊:Journal of Molecular Biology, 页码:137-147 , 文章类型: Article,,卷期:2012年416-1]
- The study of the folding of single domains, in the context of their multidomain environment, is important because more than 70% of eukaryotic proteins are composed of multiple domains. The structures of the tandem immuno...
- Key Structural Features of the Actin Filament Arp2/3 Complex Branch Junction Revealed by Molecular Simulation
[作者:Pfaendtner, J; Volkmann, N; Hanein, D; Dalhaimer, P; Pollard, TD; Voth, GA,期刊:Journal of Molecular Biology, 页码:148-161 , 文章类型: Article,,卷期:2012年416-1]
- We investigated the structure, properties and dynamics of the actin filament branch junction formed by actin-related protein (Arp) 2/3 complex using all-atom molecular dynamics (MD) simulations based on a model fit to a ...
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