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文章名     作者     期刊名     摘要     卷     期         如果没有找到您所需要的文献，请点击 ——此处申请     共12条记录   Rational Methods for the Selection of Diverse Screening Compounds [作者：HUGGINS DAVID J; VENKITARAMAN ASHOK R; SPRING DAVID R,期刊：ACS CHEMICAL BIOLOGY, 页码：208-217 , 文章类型： Review，,卷期：2011年6-3] Traditionally a pursuit of large pharmaceutical companies, high-throughput screening assays are becoming increasingly common within academic government laboratories This shift has been instrumental in enabling projects t... Teasing Out Kinase Function in T Cells (vol 11, pg 1085, 2010) [作者：SOARES JITESH A,期刊：ACS CHEMICAL BIOLOGY, 页码：288-288 , 文章类型： Correction，,卷期：2011年6-3] The Antimalarial Ferroquine: Role of the Metal and Intramolecular Hydrogen Bond in Activity and Resistance [作者：DUBAR FAUSTINE; EGAN TIMOTHY J; PRADINES BRUNO; KUTER DAVID; NCOKAZI KANYILE K; FORGE DELPHINE; PAUL JEANFRANCOIS; PIERROT CHRISTINE; KALAMOU HADIDJATOU; KHALIFE JAMAL; BUISINE ERIC; ROGIER CHRISTOPHE; VEZIN HERVE; FORFAR ISABELLE; SLOMIANNY CHRISTIAN; TRIVELLI XAVIER; KAPISHNIKOV SERGEY; LEISEROWITZ LESLIE; DIVE DANIEL; BIOT CHRISTOPHE,期刊：ACS CHEMICAL BIOLOGY, 页码：275-287 , 文章类型： Article，,卷期：2011年6-3] Inhibition of hemozoin biocrystallization is considered the main mechanism of, action of 4-aminoquinoline antimalarials including chloroquine (CQ) but cannot,fully explain the activity of ferroquine (FQ) which has been r... Discovery of a Small Molecule PDI Inhibitor That Inhibits Reduction of HIV-1 Envelope Glycoprotein gp120 [作者：KHAN MAOLA M G; SIMIZU SIRO; LAI NGIT SHIN; KAWATANI MAKOTO; SHIMIZU TAKESHI; OSADA HIROYUKI,期刊：ACS CHEMICAL BIOLOGY, 页码：245-251 , 文章类型： Article，,卷期：2011年6-3] Protein disulfide isomerase (PDI) is a promiscuous protein with multifunctional properties. PDI mediates proper protein folding by,oxidation or isomerization and disrupts disulfide bonds by reduction. The entry of HIV-1 ... Discovery and Characterization of Non-ATP Site Inhibitors of the Mitogen Activated Protein (MAP) Kinases [作者：COMESS KENNETH M; SUN CHAOHONG; ABADZAPATERO CELE; GOEDKEN ERIC R; GUM REBECCA J; BORHANI DAVID W; ARGIRIADI MARIA; GROEBE DUNCAN R; JIA YONG; CLAMPIT JILL E; HAASCH DEANNA L; SMITH HARRIET T; WANG SANYI; SONG DANYING; COEN MICHAEL L; CLOUTIER TIMOTHY E; TANG HUA; CHENG XUEHENG; QUINN CHRISTOPHER; LIU BO; XIN ZHILI; LIU GANG; FRY ELIZABETH H; STOLL VINCENT; NG TERESA I; BANACH DAVID; MARCOTTE DOUG; BURNS DAVID J; CALDERWOOD DAVID J; HAJDUK PHILIP J,期刊：ACS CHEMICAL BIOLOGY, 页码：234-244 , 文章类型： Article，,卷期：2011年6-3] Inhibition of protein kinases has validated therapeutic utility for cancer, with at least seven kinase inhibitor drugs on the market Protein-kinase inhibition also has significant potential for a variety of other disease... Enhancement of the Immunogenicity of Synthetic Carbohydrate Vaccines by Chemical Modifications of STn Antigen [作者：YANG FAN; ZHENG XIUJING; HUO CHANGXIN; WANG YUE; ZHANG YE; YE XINSHAN,期刊：ACS CHEMICAL BIOLOGY, 页码：252-259 , 文章类型： Article，,卷期：2011年6-3] The abnormal glycans expressed on the surface of tumor cells, known as tumor-associated carbohydrate antigen's, increase the chance to develop carbohydrate-based anticancer vaccines. However, carbohydrate antigens pose c... Paramagnetic Relaxation Assisted Docking of a Small Indole Compound in the HIV-1 gp41 Hydrophobic Pocket [作者：GOCHIN MIRIAM; ZHOU GUANGYAN; PHILLIPS AARON H,期刊：ACS CHEMICAL BIOLOGY, 页码：267-274 , 文章类型： Article，,卷期：2011年6-3] The hydrophobic pocket contained within the gp41 coiled coil is an important target for small molecules designed to inhibit HIV-1 fusion. While various screening experiments have identified molecules purported to bind in... Encapsulating Bacteria in Agarose Microparticles Using Microfluidics for High-Throughput Cell Analysis and Isolation [作者：EUN YEJIN; UTADA ANDREW S; COPELAND MATTHEW F; TAKEUCHI SHOJI; WEIBEL DOUGLAS B,期刊：ACS CHEMICAL BIOLOGY, 页码：260-266 , 文章类型： Article，,卷期：2011年6-3] The high-throughput analysis and isolation of bacterial:cells encapsulated in agarose microparticles using-fluorescence-activated cell sorting (FACS) is described. Flow-focusing microfluidic systems were used to create m... Celebrating the International Year of Chemistry [作者：SOARES JITESH,期刊：ACS CHEMICAL BIOLOGY, 页码：199-199 , 文章类型： Editorial Material，,卷期：2011年6-3] Identification of SR3335 (ML-176): A Synthetic ROR alpha Selective Inverse Agonist [作者：KUMAR NARESH; KOJETIN DOUGLAS J; SOLT LAURA A; KUMAR K GANESH; NUHANT PHILIPPE; DUCKETT DEREK R; CAMERON MICHAEL D; BUTLER ANDREW A; ROUSH WILLIAM R; GRIFFIN PATRICK R; BURRIS THOMAS P,期刊：ACS CHEMICAL BIOLOGY, 页码：218-222 , 文章类型： Article，,卷期：2011年6-3] Several nuclear receptors (NRs) are still characterized as orphan.. receptors because ligands have not yet been identified for these proteins:: The retinoic acid receptor related receptors (RORs) have no well-defined phy... A Fluorogenic, Small Molecule Reporter for Mammalian Phospholipase C Isozymes [作者：HUANG WEIGANG; HICKS STEPHANIE N; SONDEK JOHN; ZHANG QISHENG,期刊：ACS CHEMICAL BIOLOGY, 页码：223-228 , 文章类型： Article，,卷期：2011年6-3] Phospholipase C isozymes (PLCs) catalyze the conversion of the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP2) into two second messengers, inositol 1,4,5-trisphosphate and diacylglycerol. This family of enzym... Identification of SAP155 as the Target of GEX1A (Herboxidiene), an Antitumor Natural Product [作者：HASEGAWA MAKOTO; MIURA TATSUHIRO; KUZUYA KOUJI; INOUE AYU; KI SE WON; HORINOUCHI SUEHARU; YOSHIDA TETSUO; KUNOH TATSUKI; KOSEKI KOICHI; MINO KOSHIKI; SASAKI RYUZO; YOSHIDA MINORU; MIZUKAMI TAMIO,期刊：ACS CHEMICAL BIOLOGY, 页码：229-233 , 文章类型： Article，,卷期：2011年6-3] GEX1A is a microbial product with antitumor activity. HeLa cells cultured with GEX1A accumulated p27(Kip) and its C-terminally truncated form p27*. GEX1A inhibited the pre-mRNA splicing of p27, producing p27* from the un...