- Lower Risk of Advanced Neoplasia Among Patients With a Previous Negative Result From a Fecal Test for Colorectal Cancer
[作者:Denters, MJ; Deutekom, M; Bossuyt, PM; Stroobants, AK; Fockens, P; Dekker, E,期刊:Gastroenterology, 页码:497-504 , 文章类型: Article,,卷期:2012年142-3]
- BACKGROUND & AIMS: Consecutive rounds of fecal occult blood tests (FOBTs) are used to screen for colorectal cancer (CRC); they detect precursor lesions and early-stage disease. We assessed whether the positivity rate and...
- Granulocyte Colony-Stimulating Factor Mobilizes CD34(+) Cells and Improves Survival of Patients With Acute-on-Chronic Liver Failure
[作者:Garg, V; Garg, H; Khan, A; Trehanpati, N; Kumar, A; Sharma, BC; Sakhuja, P; Sarin, SK,期刊:Gastroenterology, 页码:505-U156 , 文章类型: Article,,卷期:2012年142-3]
- BACKGROUND & AIMS: Acute-on-chronic liver failure (ACLF) develops in patients with chronic liver disease and has high mortality. Mobilization of bone marrow-derived stem cells with granulocyte colony-stimulating factor (...
- Polymorphisms Near IL28B and Serologic Response to Peginterferon in HBeAg-Positive Patients With Chronic Hepatitis B
[作者:Sonneveld, MJ; Wong, VWS; Woltman, AM; Wong, GLH; Cakaloglu, Y; Zeuzem, S; Buster, EHCJ; Uitterlinden, AG; Hansen, BE; Chan, HLY; Janssen, HLA,期刊:Gastroenterology, 页码:513-U165 , 文章类型: Article,,卷期:2012年142-3]
- BACKGROUND & AIMS: A limited number of patients with hepatitis B e antigen (HBeAg)-positive chronic hepatitis B respond to treatment with peginterferon alfa (PEG-IFN). We investigated whether IL28B genotypes are associat...
- Reciprocal Activation Between PLK1 and Stat3 Contributes to Survival and Proliferation of Esophageal Cancer Cells
[作者:Zhang, Y; Du, XL; Wang, CJ; Lin, DC; Ruan, X; Feng, YB; Huo, YQ; Peng, HY; Cui, JL; Zhang, TT; Wang, YQ; Zhang, HB; Zhan, QM; Wang, MR,期刊:Gastroenterology, 页码:521-U178 , 文章类型: Article,,卷期:2012年142-3]
- BACKGROUND & AIMS: Aberrant activation of the signal transducer and activator of transcription (Stat) 3 and overexpression of polo-like kinase (PLK) 1 each have been associated with cancer pathogenesis. The mechanisms an...
- Disruption of Klf4 in Villin-Positive Gastric Progenitor Cells Promotes Formation and Progression of Tumors of the Antrum in Mice
[作者:Li, Q; Jia, ZL; Wang, L; Kong, XY; Li, Q; Guo, K; Tan, DF; Le, XD; Wei, DY; Huang, SY; Mishra, L; Xie, KP,期刊:Gastroenterology, 页码:531-542 , 文章类型: Article,,卷期:2012年142-3]
- BACKGROUND & AIMS: Kruppel-like factor 4 (Klf4) is a putative gastric tumor suppressor gene. Rare, villin-positive progenitor cells in the gastric antrum have multilineage potential. We investigated the function of Klf4 ...
- 4-Hydroxy-2-Nonenal Mediates Genotoxicity and Bystander Effects Caused by Enterococcus faecalis-Infected Macrophages
[作者:Wang, XM; Yang, YH; Moore, DR; Nimmo, SL; Lightfoot, SA; Huycke, MM,期刊:Gastroenterology, 页码:543-U206 , 文章类型: Article,,卷期:2012年142-3]
- BACKGROUND & AIMS: Enterococcus faecalis is a human intestinal commensal that produces extracellular superoxide and promotes chromosome instability via macrophage-induced bystander effects. We investigated the ability of...
- T-Cell Response to Gluten in Patients With HLA-DQ2.2 Reveals Requirement of Peptide-MHC Stability in Celiac Disease
[作者:Bodd, M; Kim, CY; Lundin, KEA; Sollid, LM,期刊:Gastroenterology, 页码:552-561 , 文章类型: Article,,卷期:2012年142-3]
- BACKGROUND & AIMS: Celiac disease is a diet-induced, T cell-mediated enteropathy. The HLA variant DQ2.5 increases risk of the disease, and the homologous DQ2.2 confers a lower level of risk. As many as 5% of patients wit...
- Smad4-Mediated Signaling Inhibits Intestinal Neoplasia by Inhibiting Expression of beta-Catenin
[作者:Freeman, TJ; Smith, JJ; Chen, X; Washington, MK; Roland, JT; Means, AL; Eschrich, SA; Yeatman, TJ; Deane, NG; Beauchamp, RD,期刊:Gastroenterology, 页码:562-U228 , 文章类型: Article,,卷期:2012年142-3]
- BACKGROUND & AIMS: Mutational inactivation of adenomatous polyposis coli (APC) is an early event in colorectal cancer (CRC) progression that affects the stability and increases the activity of beta-catenin, a mediator of...
- beta-Catenin Inhibits Promyelocytic Leukemia Protein Tumor Suppressor Function in Colorectal Cancer Cells
[作者:Satow, R; Shitashige, M; Jigami, T; Fukami, K; Honda, K; Kitabayashi, I; Yamada, T,期刊:Gastroenterology, 页码:572-581 , 文章类型: Article,,卷期:2012年142-3]
- BACKGROUND & AIMS: Loss of promyelocytic leukemia protein (PML) nuclear body (NB) formation has been reported in colorectal and other solid tumors. However, genetic alteration of PML is rarely observed in these tumors; t...
- Glucocorticoid-Induced Tumor Necrosis Factor Receptor Family-Related Protein Regulates CD4(+)T Cell-Mediated Colitis in Mice
[作者:Liao, GX; Detre, C; Berger, SB; Engel, P; Malefyt, RD; Herzog, RW; Bhan, AK; Terhorst, C,期刊:Gastroenterology, 页码:582-U256 , 文章类型: Article,,卷期:2012年142-3]
- BACKGROUND & AIMS: The glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR; also called TNFRSF18 or CD357) regulates the T cell-mediated immune response and is present on surfaces of regula...
- Direct and Indirect Contribution of Human Embryonic Stem Cell-Derived Hepatocyte-Like Cells to Liver Repair in Mice
[作者:Woo, DH; Kim, SK; Lim, HJ; Heo, J; Park, HS; Kang, GY; Kim, SE; You, HJ; Hoeppner, DJ; Kim, Y; Kwon, H; Choi, TH; Lee, JH; Hong, SH; Song, KW; Ahn, EK; Chenoweth, JG; Tesar, PJ; McKay, RDG; Kim, JH,期刊:Gastroenterology, 页码:602-611 , 文章类型: Article,,卷期:2012年142-3]
- BACKGROUND & AIMS: Many studies of embryonic stem cells have investigated direct cell replacement of damaged tissues, but little is known about how donor cell-derived signals affect host tissue regeneration. We investiga...
- Fibromodulin, an Oxidative Stress-Sensitive Proteoglycan, Regulates the Fibrogenic Response to Liver Injury in Mice
[作者:Mormone, E; Lu, YK; Ge, XD; Fiel, MI; Nieto, N,期刊:Gastroenterology, 页码:612-U294 , 文章类型: Article,,卷期:2012年142-3]
- BACKGROUND & AIMS: Collagen I deposition contributes to liver fibrosis, yet little is known about other factors that mediate this process. Fibromodulin is a liver proteoglycan that regulates extracellular matrix organiza...
- Inhibition of Cdc25A Suppresses Hepato-renal Cystogenesis in Rodent Models of Polycystic Kidney and Liver Disease
[作者:Masyuk, TV; Radtke, BN; Stroope, AJ; Banales, JM; Masyuk, AI; Gradilone, SA; Gajdos, GB; Chandok, N; Bakeberg, JL; Ward, CJ; Ritman, EL; Kiyokawa, H; LaRusso, NF,期刊:Gastroenterology, 页码:622-U310 , 文章类型: Article,,卷期:2012年142-3]
- BACKGROUND & AIMS: In polycystic kidney disease and polycystic liver disease (PLD), the normally nonproliferative hepato-renal epithelia acquire a proliferative, cystic phenotype that is linked to overexpression of cell ...
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