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  • Directed Differentiation of Human Embryonic Stem Cells into Functional Retinal Pigment Epithelium Cells
    [作者:Idelson, M; Alper, R; Obolensky, A; Ben-Shushan, E; Hemo, I; Yachimovich-Cohen, N; Khaner, H; Smith, Y; Wiser, O; Gropp, M; Cohen, MA; Even-Ram, S; Berman-Zaken, Y; Matzrafi, L; Rechavi, G; Banin, E; Reubinoff, B,期刊:Cell Stem Cell, 页码:396-408 , 文章类型: Article,,卷期:2009年5-4]
  • Dysfunction and loss of retinal pigment epithelium (RPE) leads to degeneration of photoreceptors in age-related macular degeneration and subtypes of retinitis pigmentosa. Human embryonic stem cells (hESCs) may serve as a...
  • Uncovering Early Response of Gene Regulatory Networks in ESCs by Systematic Induction of Transcription Factors
    [作者:Nishiyama, A; Xin, L; Sharov, AA; Thomas, M; Mowrer, G; Meyers, E; Piao, YL; Mehta, S; Yee, S; Nakatake, Y; Stagg, C; Sharova, L; Correa-Cerro, LS; Bassey, U; Hoang, H; Kim, E; Tapnio, R; Qian, Y; Dudekula, D; Zalzman, M; Li, MX; Falco, G; Yang, HT; Lee, SL; Monti, M; Stanghellini, I; Islam, MN; Nagaraja, R; Goldberg, I; Wang, WD; Longo, DL; Schlessinger, D; Ko, MSH,期刊:Cell Stem Cell, 页码:420-433 , 文章类型: Article,,卷期:2009年5-4]
  • To examine transcription factor (TF) network(s), we created mouse ESC lines, in each of which 1 of 50 TFs tagged with a FLAG moiety is inserted into a ubiquitously controllable tetracycline-repressible locus. Of the 50 T...
  • Generation of Induced Pluripotent Stem Cells from Human Cord Blood
    [作者:Haase, A; Olmer, R; Schwanke, K; Wunderlich, S; Merkert, S; Hess, C; Zweigerdt, R; Gruh, I; Meyer, J; Wagner, S; Maier, LS; Han, DW; Glage, S; Miller, K; Fischer, P; Scholer, HR; Martin, U,期刊:Cell Stem Cell, 页码:434-441 , 文章类型: Article,,卷期:2009年5-4]
  • Induced pluripotent stem cells (iPSCs) may represent an ideal cell source for future regenerative therapies. A critical issue concerning the clinical use of patient-specific iPSCs is the accumulation of mutations in soma...
  • Oxysterols Drive Dopaminergic Neurogenesis from Stem Cells
    [作者:Ma, DKK; Ming, GL; Song, HJ,期刊:Cell Stem Cell, 页码:343-344 , 文章类型: Editorial Material,,卷期:2009年5-4]
  • Stem cell therapy for Parkinson's disease requires effective production of dopaminergic neurons. In this issue of Cell Stem Cell, Sacchetti et al. (2009) report an unexpected role of liver X receptors and their ligand, o...
  • The Human Egg Is Back
    [作者:Cibelli, J,期刊:Cell Stem Cell, 页码:345-346 , 文章类型: Editorial Material,,卷期:2009年5-4]
  • In a recent issue of Nature, Tachibana et al. (2009) conducted chromosomal transfer into recipient primate oocytes to yield live offspring or monkey ESCs with no contribution of donor mitochondria. The success of this te...
  • Sense and Serendipity Aid RPE Generation
    [作者:Corneo, B; Temple, S,期刊:Cell Stem Cell, 页码:347-348 , 文章类型: Editorial Material,,卷期:2009年5-4]
  • Retinal pigment epithelium (RPE) is a valuable cell type for a number of blinding disorders. In this issue of Cell Stem Cell, Idelson et al. (2009) use Nicotinamide and Activin A to markedly improve RPE yield from human ...
  • Time to Cut the Cord: Placental HSCs Grow Up
    [作者:Zovein, AC; Iruela-Arispe, ML,期刊:Cell Stem Cell, 页码:351-352 , 文章类型: Editorial Material,,卷期:2009年5-4]
  • In this issue of Cell Stem Cell, Robin et al. (2009) demonstrate the robust hematopoietic stem cell capacity of the human placenta. The study investigates components of the placental niche and paves the way for clinical ...
  • Regeneration Next: Toward Heart Stem Cell Therapeutics
    [作者:Hansson, EM; Lindsay, ME; Chien, KR,期刊:Cell Stem Cell, 页码:364-377 , 文章类型: Review,,卷期:2009年5-4]
  • Stem cell biology holds great promise for a new era of cell-based therapy, sparking considerable interest among scientists, clinicians, and their patients. However, the translational arm of stem cell science is in a rela...